Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14-O-hemiglutarate in mouse and human serum in vitro: Implications for the design of preclinical studies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 2, 2000, Pages 829-834

  Nagy, Attila ^a   Plonowski, Artur ^a,b   Schally, Andrew V ^a,c  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diisopropyl fluorophosphate; Esterase inhibitors; Targeted chemotherapeutic agents; Tolerance

Indexed keywords

2 PYRROLINODOXORUBICIN; BIS(4 NITROPHENYL) PHOSPHATE; CARBOXYLESTERASE; CYTOTOXIC AGENT; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLLYSYLVALYLCYSTEINYLTHREONINAMIDE 2,7 DISULFIDE 2 PYRROLINODOXORUBICIN; DOXORUBICIN 14 O HEMIGLUTARATE; DYFLOS; GONADORELIN DERIVATIVE; GONADORELIN[6 DEXTRO LYSINE] DOXORUBICIN; SOMATOSTATIN DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG MECHANISM; DRUG TARGETING; DRUG TOLERABILITY; HUMAN; IN VITRO STUDY; MALE; METHODOLOGY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

ADULT; ANIMALS; ANTINEOPLASTIC AGENTS; BOMBESIN; CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; DRUG STABILITY; GONADOTROPIN-RELEASING HORMONE; HALF-LIFE; HUMANS; HYDROLYSIS; ISOFLUROPHATE; MALE; MICE; MICE, NUDE; NITROPHENOLS; PARAOXON; PYRROLES; WEIGHT LOSS;

ANIMALIA; MUS MUSCULUS;

EID: 0034681171     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.2.829     Document Type: Article

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