Synthesis and biological evaluation of cytotoxic analogs of somatostatin containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 4, 1998, Pages 1794-1799

  Nagy, Attila ^a   Schally, Andrew V ^a,b   Halmos, Gábor ^a   Armatis, Patricia ^a   Cai, Ren Zhi ^a   Csernus, Valér ^a,c   Kovács, Magdolna ^a,c   Koppán, Miklós ^a,c   Szepesház, Károly ^a   Kahán, Zsuzsanna ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Antiproliferative activity; Hybrid molecules; Receptor binding; Targeted chemotherapeutic agents

Indexed keywords

9 FLUORENYLMETHYL CHLOROFORMATE; CYTOTOXIC AGENT; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLLYSYLVALYLCYSTEINYLTHREONINAMIDE 2,7 DISULFIDE; DOXORUBICIN; DOXORUBICIN DERIVATIVE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; N,N DIMETHYLFORMAMIDE; PYRROLINE DERIVATIVE; RADIOLIGAND; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; TETRAZOLIUM; TRIFLUOROACETIC ACID; VAPREOTIDE;

ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; GROWTH HORMONE RELEASE; HUMAN; HUMAN CELL; HYPOPHYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; CELL MEMBRANE; CYTOTOXINS; DOXORUBICIN; GROWTH INHIBITORS; HUMANS; PITUITARY GLAND; PYRROLES; RATS; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; TUMOR CELLS, CULTURED;

AGOUTI PACA; ANIMALIA;

EID: 0032539609     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.4.1794     Document Type: Article

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