Cytotoxic analogs of luteinizing hormone-releasing hormone containing doxorubicin or 2-pyrrolinodoxorubicin, a derivative 500-1000 times more potent

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 14, 1996, Pages 7269-7273

  Nagy, Attila ^a,b   Schally, Andrew V ^a,b   Armatis, Patricia ^a   Szepeshazi, Karoly ^a,b   Halmos, Gabor ^a,b   Kovacs, Magdolna ^a,b   Zarandi, Marta ^a,b   Groot, Kate ^a   Miyazaki, Masahiro ^a,b   Jungwirth, Andreas ^a,b   Horvath, Judit ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antitumor activity; hybrid molecules; receptor binding; targeted chemotherapeutic agents

Indexed keywords

2 PYRROLINODOXORUBICIN; DOXORUBICIN; DOXORUBICIN DERIVATIVE; GONADORELIN DERIVATIVE; GONADORELIN[6 DEXTRO LYSINE] 2 PYRROLINODOXORUBICIN; GONADORELIN[6 DEXTRO LYSINE] DOXORUBICIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER INHIBITION; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BINDING, COMPETITIVE; BREAST NEOPLASMS; DOXORUBICIN; FEMALE; GONADOTROPIN-RELEASING HORMONE; HUMANS; LUTEINIZING HORMONE; MOLECULAR SEQUENCE DATA; PITUITARY GLAND; PYRROLES; RATS; RECEPTORS, LHRH; TUMOR CELLS, CULTURED;

EID: 8944225497     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.14.7269     Document Type: Article

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