Synthesis and biological activity of β-glucuronyl carbamate-based prodrugs of paclitaxel as potential candidates for ADEPT

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 2, 1997, Pages 405-414

  De Bont, Dries B A ^a,c   Leenders, Ruben G G ^a   Haisma, Hidde J ^b   Van Der Meulen Muileman, Ida ^b   Scheeren, Hans W ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; PACLITAXEL; PACLITAXEL DERIVATIVE; PRODRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVATION; DRUG ACTIVITY; DRUG DESIGN; DRUG PURIFICATION; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TARGETING; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANTIBODIES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CATALYSIS; DRUG DELIVERY SYSTEMS; GLUCURONATES; GLUCURONIDASE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PACLITAXEL; PRODRUGS; TAXOIDS; TUMOR CELLS, CULTURED;

EID: 0031081690     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00249-0     Document Type: Article

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