5-Substituted analogues of 3-hydroxymethyl-5-aziridinyl-1 -methyl-2-[1H-indole-4,7-dione]prop-2-en-1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: Structure-cytotoxicity in vitro

Anti-Cancer Drug Design

Volumn 13, Issue 2, 1998, Pages 105-123

  Jaffar, Mohammed ^a   Naylor, Matthew A ^b   Robertson, Naomi ^a   Lockyer, Stacey D ^a   Phillips, Roger M ^c   Everett, Steven A ^b   Adams, Gerald E ^b   Stratford, Ian J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MOUNT VERNON HOSPITAL   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Bioreductive agents; EO9 regioisomers; Hypoxia selective; Indoloquinone; Prodrugs

Indexed keywords

5 (1 AZIRIDINYL) 3 HYDROXYMETHYL 2 (3 HYDROXY 1 PROPENYL) 1 METHYL 4,7 INDOLEDIONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; NONHUMAN; PRIORITY JOURNAL; REDUCTION; TUMOR CELL LINE;

AEROBIOSIS; ANIMALS; ANTINEOPLASTIC AGENTS; AZIRIDINES; CARCINOMA, NON-SMALL-CELL LUNG; CELL HYPOXIA; CELL LINE; CRICETINAE; CRICETULUS; FIBROBLASTS; HUMANS; INDOLEQUINONES; INDOLES; LUNG NEOPLASMS; NAD(P)H DEHYDROGENASE (QUINONE); STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0031930369     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

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