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Volumn 9, Issue 6-7, 1997, Pages 357-369

Nitro reduction as an electronic switch for bioreductive drug activation

Author keywords

ADEPT; Bioreductive drugs; GDEPT; Hypoxia; Nitro reduction; Nitrogen mustard

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; NITRO DERIVATIVE; PRODRUG; RADIOSENSITIZING AGENT;

EID: 0031306972     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (48)

References (89)
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    • Naylor, M. A.; O'Neill, P.; Threadgill, M. D.; Cole, S.; Stratford, I. J.; Adams, G. E.; Fielden, E. M.; Suto, M. J.; Stier, M. A. Synthesis and evaluation of a-(((2haloethyl)amino)methyI)-2-nitro-lH-imidazole-1-ethanols as prodrugs of a-((l-aziridinyl)methyl)-2-nitro-lH-imidazole-lethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins. 1990.
    • Jenkins, T. C.; Naylor, M. A.; O'Neill, P.; Threadgill, M. D.; Cole, S.; Stratford, I. J.; Adams, G. E.; Fielden, E. M.; Suto, M. J.; Stier, M. A. Synthesis and evaluation of a-(((2haloethyl)amino)methyI)-2-nitro-lH-imidazole-1-ethanols as prodrugs of a-((l-aziridinyl)methyl)-2-nitro-lH-imidazole-lethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins. J. Med. Chem. 33:2603-2610; 1990.
    • J. Med. Chem. , vol.33 , pp. 2603-2610
    • Jenkins, T.C.1
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    • 0028864273 scopus 로고
    • Pruijn, F. B. Hypoxia-activated prodrugs as antitumour agents: Strategies for maximizing tumor cell killing.
    • Wilson, W. R.; Pruijn, F. B. Hypoxia-activated prodrugs as antitumour agents: Strategies for maximizing tumor cell killing. Clin. Exp. Pharmacol. Physiol. 22:881-885; 1995.
    • (1995) Clin. Exp. Pharmacol. Physiol. , vol.22 , pp. 881-885
    • Wilson, W.R.1
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    • Roberts, B. J.; Elliot, W. L.; Leopold, W. R. Chemotherapy with DMXAA (5,6-dimethylxanthenone-4acetic acid) in combination with CI-1010 (IH-imidazole-lethanol,alpha-(((2-bromoethyl)amino)methyl)-2-nitro-, mono hydrobromide (R isomer)) against advanced stage murine colon carcinoma 26. 1997.
    • Vincent, P. W.; Roberts, B. J.; Elliot, W. L.; Leopold, W. R. Chemotherapy with DMXAA (5,6-dimethylxanthenone-4acetic acid) in combination with CI-1010 (IH-imidazole-lethanol,alpha-(((2-bromoethyl)amino)methyl)-2-nitro-, mono hydrobromide (R isomer)) against advanced stage murine colon carcinoma 26. Oncol. Rep. 4:143-147; 1997.
    • Oncol. Rep. , vol.4 , pp. 143-147
    • Vincent, P.W.1
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.