Synthesis and anti-cancer activity of 2,6-disubstituted N-methylpiperidine derivatives and their N-oxides

Anti-Cancer Drug Design

Volumn 11, Issue 6, 1996, Pages 421-438

  Henderson, Nicola D ^a   Plumb, Jane A ^a   Robins, David J ^a   Workman, Paul ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

2,6 disubstituted piperidines; Anti cancer activity; Bioreduction; N oxides

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; PIPERIDINE DERIVATIVE; PRODRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CIS ISOMER; COLORECTAL CANCER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ISOMER; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; TRANS ISOMER;

ANTINEOPLASTIC AGENTS, ALKYLATING; BIOTRANSFORMATION; CARCINOMA; CELL HYPOXIA; COLORECTAL NEOPLASMS; DIHYDROLIPOAMIDE DEHYDROGENASE; HUMANS; NEOPLASM PROTEINS; NITROGEN; OXIDATION-REDUCTION; OXIDES; PIPERIDINES; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

BRASSICACEAE;

EID: 0029783393     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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