Prodrugs for targeting hypoxic tissues: Regiospecific elimination of aspirin from reduced indolequinones

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 1, 1999, Pages 113-118

  Jaffar, M ^a   Everett, S A ^b   Naylor, M A ^b   Moore, S G ^a   Ulhaq, S ^a,c   Patel, K B ^b   Stratford, M R L ^b   Nolan, J ^b   Wardman, P ^b   Stratford, I J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MOUNT VERNON HOSPITAL   (United Kingdom)

^c UNIVERSITY OF REGINA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYTOTOXIC AGENT; INDOLE DERIVATIVE; INDOLEQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; DRUG BINDING; DRUG ELIMINATION; DRUG SYNTHESIS; DRUG TARGETING; ISOMERISM; REDUCTION;

ANIMALS; ANOXIA; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS; ASPIRIN; FREE RADICALS; HUMANS; INDOLES; NEOPLASMS; OXIDATION-REDUCTION; PRODRUGS; QUINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032945037     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00695-7     Document Type: Article

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