Monoclonal antibody conjugates of doxorubicin prepared with branched linkers: A novel method for increasing the potency of doxorubicin immunoconjugates

Bioconjugate Chemistry

Volumn 10, Issue 2, 1999, Pages 279-288

  King, H Dalton ^a   Yurgaitis, Derek ^a   Willner, David ^a   Firestone, Raymond A ^a,b   Yang, Michael B ^a   Lasch, Shirley J ^a   Hellström, Karl Erik ^c,d   Trail, Pamela A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^d PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CHAINS; CYTOTOXICITY; PH;

ANTIBODY CONJUGATE; DOXORUBICIN; HYDRAZONE LINKERS; IMMUNOCONJUGATE; IN-VITRO; MOLAR RATIO; NOVEL METHODS; NOVEL SERIES; PHYSIOLOGICAL PH; SINGLE CHAINS;

MONOCLONAL ANTIBODIES;

ANIMALIA;

EID: 0033106074     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc980100i     Document Type: Article

References (13)

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3. Sjogren, H. O., Isaksson, M., Willner, D., Hellstrom, I., Hellstrom, K. E., and Trail, P. A. (1997) Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats. Cancer Res. 57, 4530-4536.
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