N-substituted 2-(2,6-dinitrophenylamino)propanamides: Novel prodrugs that release a primary amine via nitroreduction and intramolecular cyclization

Journal of Medicinal Chemistry

Volumn 42, Issue 3, 1999, Pages 346-355

  Sykes, Bridget M ^a   Atwell, Graham J ^a   Hogg, Alison ^b   Wilson, William R ^b   O'Connor, Charmian J ^b   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,6 DINITROPHENYLAMINO)PROPANAMIDE DERIVATIVE; AMIDE; AMINE; ANILINE DERIVATIVE; N HYDROXYDIHYDROQUINOXALINONE DERIVATIVE; NITROREDUCTASE; PARA ANISIDINE; PHENYLCARBOXAMIDE; PRODRUG; PROPIONAMIDE DERIVATIVE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYCLIZATION; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; INTRAPERITONEAL DRUG ADMINISTRATION; METHYLATION; MOUSE; NONHUMAN; RADIATION; REDUCTION;

AMIDES; AMINES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED C3H; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; OXIDATION-REDUCTION; PRODRUGS;

EID: 0032972169     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960783s     Document Type: Article

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