Presentation of antigens by MHC class II molecules: Getting the most out of them

Molecular Immunology

Volumn 38, Issue 5, 2001, Pages 329-346

  Villadangos, J A ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Antigen presenting cells; Cathepsins; Endocytic route; Invariant chain; MHC polymorphism; Proteolysis

Indexed keywords

ANTIGEN; CARBOHYDRATE; CHAPERONE; HYDROLASE; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; PROTEINASE;

ACIDIFICATION; ANTIGEN PRESENTING CELL; CELL MEMBRANE; CELL SURFACE; DENDRITIC CELL; DISULFIDE BOND; ENDOCYTOSIS; GENETIC POLYMORPHISM; HYDROLYSIS; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; REVIEW; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ENDOCYTOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LIGANDS; PEPTIDES;

EID: 0034773298     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(01)00069-4     Document Type: Review

References (185)

1. The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation
2. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes
3. Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles
4. Phosphorylation of the invariant chain by protein kinase C regulates MHC class II trafficking to antigen-processing compartments
5. Control of antigen presentation by a single protease cleavage site
6. Functional HLA-DM on the surface of B cells and immature dendritic cells
7. Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules
8. Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)
9. CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms
10. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
11. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
12. Intracellular traffic to compartments for MHC class II peptide loading: Signals for endosomal and polarized sorting
13. Immunobiology of dendritic cells
14. Selective modulation of the major histocompatibility complex class II antigen presentation pathway following B cell receptor ligation and protein kinase C activation
15. Structure and polymorphism of murine and human class II major histocompatibility antigens
16. How MHC class II molecules reach the endocytic pathway
17. A fragment of the major histocompatibility complex class II-associated p41 invariant chain inhibits cruzipain, the major cysteine proteinase from Trypanosoma cruzi
18. Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.
19. Allelic differences affecting invariant chain dependency of MHC class II subunit assembly
20. Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression
21. Role for intracellular proteases in the processing and transport of class II HLA antigens
22. Antigen presentation. A protease draws first blood
23. Proteases and proteolysis in the lysosome
24. Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain
25. Early endosomes are required for major histocompatiblity complex class II transport to peptide-loading compartments
26. Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes
27. An LI and ML motif in the cytoplasmic tail of the MHC-associated invariant chain mediate rapid internalization
28. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
29. Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum
30. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
31. The transmembrane segment of invariant chain mediates binding to MHC class II molecules in a CLIP-independent manner
32. Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules
33. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
34. Alteration of a single hydrogen bond between class II and peptide results in rapid degradation of class II after Ii removal
35. Emerging roles for cysteine proteases in human biology
36. Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase
37. Cloning and expression of mouse legumain, a lysosomal endopeptidase
38. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
39. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size
40. Reduction of disulfide bonds within lysosomes is a key step in antigen processing
41. Invariant chain structure and MHC class II function
42. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
43. Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
44. Modification of the amino terminus of a class II epitope confers resistance to degradation by CD13 on dendritic cells and enhances presentation to T cells
45. In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses
46. In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen
47. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells
48. Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcg-receptors
49. The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules
50. Structure of peptides associated with class I and class II MHC molecules
51. Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells
52. Characterization of MHC class II-presented peptides generated from an antigen targeted to different endocytic compartments
53. Cytokines regulate proteolysis in major histocompatibility complex class ii-dependent antigen presentation by dendritic cells
54. Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41
55. The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain
56. Structure, function and regulation of the vacuolar (H+)-ATPases
57. The phagosome proteome: Insight into phagosome functions
58. Developmental control of endocytosis in dendritic cells by Cdc42
59. Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules
60. The role of endosomes and lysosomes in MHC class II functioning
61. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
62. Purification, cDNA cloning, and expression of a new human blood plasma glutamate carboxypeptidase homologous to N-acetyl-aspartyl-alpha-glutamate carboxypeptidase/prostate-specific membrane antigen
63. Immunocompetent astrocytes and microglia display major differences in the processing of the invariant chain and in the expression of active cathepsin L and cathepsin S
64. Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms
65. Isolation and quantitation of a minor determinant of hen egg white lysozyme bound to I-Ak by using peptide-specific immunoaffinity
66. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules
67. Cysteinylation of MHC class II ligands: Peptide endocytosis and reduction within APC influences T cell recognition
68. Cross-presentation, dendritic cells, tolerance and immunity
69. Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes
70. Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad
71. The formation of immunogenic major histocompatibility complex class II- peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
72. HLA class II-restricted presentation of cytoplasmic measles virus antigens to cytotoxic T cells
73. One of two unstructured domains of Ii becomes ordered in complexes with MHC class II molecules
74. Regulation of antigen presentation by acidic pH
75. Reduction of disulfide bonds during antigen processing: Evidence from a thiol-dependent insulin determinant
76. Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC
77. Peptide exchange in MHC molecules
78. Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen
79. Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules
80. Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74)
81. HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH
82. The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules
83. Editing of the HLA-DR-peptide repertoire by HLA-DM
84. Self-release of CLIP in peptide loading of HLA-DR molecules
85. Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages
86. Mechanisms of antigen uptake for presentation
87. T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides
88. Thyropins - New structurally related proteinase inhibitors
89. The p41 isoform of Invariant Chain is a chaperone for Cathepsin L
90. Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins
91. Distinct antigen MHC class II complexes generated by separate processing pathways
92. Intracellular transport of class II MHC molecules directed by invariant chain
93. Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC class II- positive vesicles in immature dendritic cells
94. The three-dimensional structure of peptide-MHC complexes
95. The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments
96. Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells
97. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
98. The lysosomal cysteine proteases
99. Endocytosis and molecular sorting
100. Low abundance of naturally processed T-cell determinants following antigen pulsing of antigen-specific human B-cell lines
101. Immunodominance is independent of structural constraints: Each region within hen eggwhite lysozyme is potentially available upon processing of native antigen
102. pH dependence of the interaction between immunogenic peptides and MHC class II molecules. Evidence for an acidic intracellular compartment being the organelle of interaction
103. MHC molecules protect T cell epitopes against proteolytic destruction
104. Cathepsin L: Critical role in Ii degradation and CD4 T cell selection in the thymus
105. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice
106. CIIV, MIIC and other compartments for MHC class II loading
107. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes
108. Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak
109. Glycosylation signals that separate the trimerization from the mhc class II-binding domain control intracellular degradation of invariant chain
110. Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers
111. Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells
112. Class II MHC molecules can use the endogenous pathway of antigen presentation
113. Purification of the complex of cathepsin L and the MHC class II- associated invariant chain fragment from human kidney
114. Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system
115. Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection
116. Presentation on class II MHC molecules of endogenous lysozyme targeted to the endocytic pathway
117. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments
118. Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action
119. Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages
120. HLA-DM is localized to conventional and unconventional MHC class II- containing endocytic compartments
121. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
122. Developmental regulation of MHC class II transport in mouse dendritic cells
123. Antigen presentation mediated by recycling of surface HLA-DR molecules
124. A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: Possible role in supporting lysosomal proteolysis
125. Characterization of transport of newly assembled, T cell-stimulatory MHC class II-peptide complexes from MHC class II compartments to the cell surface
126. The peptide-loading complex and ligand selection during the assembly of HLA class I molecules
127. Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: Comparison to class I proteins
128. The major substrates for TAP in vivo are derived from newly synthesized proteins
129. Cathepsin S activity regulates antigen presentation and immunity
130. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading
131. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain
132. Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization
133. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
134. Sequence analysis of peptides bound to MHC class II molecules
135. A structural transition in class II major histocompatibility complex proteins at mildly acidic pH
136. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
137. Association between HLA-DM and HLA-DR in vivo
138. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain
139. Extracellular antigen processing and presentation by immature dendritic cells
140. Abundant empty class II MHC molecules on the surface of immature dendritic cells
141. Intracellular pathway for the generation of functional MHC class II peptide complexes in immature human dendritic cells
142. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: A kinetic analysis
143. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
144. Autophagy and other vacuolar protein degradation mechanisms
145. Effect of pH on MHC class II-peptide interactions
146. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
147. Cathepsin S required for normal MHC class II peptide loading and germinal center development
148. Human cathepsin S: Chromosomal localization, gene structure, and tissue distribution
149. Identification of a sequence that mediates promiscuous binding of invariant chain to MHC class II allotypes
150. The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent
151. DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules
152. Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain
153. Interaction of MHC class II molecules with the invariant chain: Role of the invariant chain (81-90) region
154. Localization of CD4+ T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing
155. Isolation and characterization of the intracellular MHC class II compartment
156. Transport of peptide-MHC class II complexes in developing dendritic cells
157. Peptide binding to active class ii mhc protein on the cell surface
158. Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs
159. Quantitation of lysozyme peptides bound to class ii mhc molecules indicates very large differences in levels of presentation
160. Minute quantities of a single immunodominant foreign epitope are presented as large nested sets by major histocompatibility complex class II molecules
161. Proteases involved in MHC class II antigen presentation
162. MHC class II expression is regulated in dendritic cells independently of invariant chain degradation
163. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM
164. Proteolysis in MHC class II antigen presentation: Who's in charge?
165. Degradation of mouse invariant chain: Roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism
166. Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing
167. Mice lacking the MHC class II-associated invariant chain
168. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization
169. Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartments
170. Capture and processing of exogenous antigens for presentation on MHC molecules
171. Antigen processing in the endocytic compartment
172. Modulation by epitope-specific antibodies of class II MHC-restricted presentation of the tetanus toxin antigen
173. Determinant protection. A hypothesis for the activity of immune response genes in the processing and presentation of antigens by macrophages
174. Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation
175. Mutations changing the kinetics of class ii mhc peptide exchange
176. Invariant chain can bind MHC class II at a site other than the peptide binding groove
177. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures
178. How MHC class II molecules acquire peptide cargo: Biosynthesis and trafficking through the endocytic pathway
179. The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed
180. Human major histocompatibility complex class II invariant chain is expressed on the cell surface
181. Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: Implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccines
182. Proteolysis and class I major histocompatibility complex antigen presentation
183. Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP)
184. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein
185. Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells