The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed

European Journal of Immunology

Volumn 28, Issue 9, 1998, Pages 2605-2618

  Wolf, Paula R ^a   Tourne, Sylvie ^b   Miyazaki, Toru ^c   Benoist, Christophe ^d   Mathis, Diane ^d   Ploegh, Hidde L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Dept of Genetics and Microbiology ^*  (Switzerland)

^c BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Antigen presentation; H 2M; MHC class II

Indexed keywords

CD4 ANTIGEN; H2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; H2 SYSTEM; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA;

EID: 0031665409     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199809)28:09<2605::AID-IMMU2605>3.0.CO;2-B     Document Type: Article

References (54)

1. Cresswell, P., Assembly, transport, and function of MHC class II molecules. Annu. Rev. Immunol. 1994. 12: 259-293.
2. Wolf, P. R. and Ploegh, H. L., How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu. Rev. Cell Dev. Biol. 1995. 11: 267-306.
3. Ghosh, P., Amaya, M., Mellins, E. and Wiley, D. C., The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 1995. 378: 457-462.
4. Bijlmakers, M. J., Bénaroch, P. and Ploegh, H. L., Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. EMBO J. 1994. 13: 2699-2707.
5. Roche, P. A. and Cresswell, P., Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature 1990. 345: 615-618.
6. Roche, P. A. and Cresswell, P., Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules. Proc. Natl. Acad. Sci. USA 1991. 88: 3150-3154.
7. Watts, C., Capture and processing of exogenous antigens for presentation by MHC molecules. Annu. Rev. Immunol. 1997. 15: 821-850.
8. Villadangos, J. A., Riese, R. J., Peters, C., Chapman, H. A. and Ploegh, H. L., Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J. Exp. Med. 1997. 186: 549-560.
9. Cho, S. G., Attaya, M. and Monaco, J. J., New class II-like genes in the murine MHC. Nature 1991. 353: 573-576.
10. Kelly, A. P., Monaco, J. J., Cho, S. G. and Trowsdale, J., A new human HLA class II-related locus, DM. Nature 1991. 353: 571-573.
11. Sanderson, F., Kleijmeer, M. J., Kelly, A., Verwoerd, D., Tulp, A., Neefjes, J. J., Geuze, H. J. and Trowsdale, J., Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 1994. 266: 1566-1569.
12. Denzin, L. K., Hammond, C. and Cresswell, P., HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J. Exp. Med. 1996. 184: 2153-2165.
13. Sanderson, F., Thomas, C., Neefjes, J. and Trowsdale, J., Association between HLA-DM and HLA-DR in vivo. Immunity 1996. 4: 87-96.
14. Denzin, L. K. and Cresswell, P., HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell 1995. 82: 155-165.
15. Sherman, M. A., Weber, D. A. and Jensen, P. E., DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide. Immunity 1995. 3: 197-205.
16. Sloan, V. S., Cameron, P., Porter, G., Gammon, M., Amaya, M., Mellins, E. and Zaller, D. M., Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 1995. 375: 802-806.
17. Riberdy, J. M., Newcomb, J. R., Surman, M. J., Barbosa, J. A. and Cresswell, P., HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature 1992. 360: 474-477.
18. Sette, A., Ceman, S., Kubo, R. T. et al., Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science 1992. 258: 1801-1804.
19. Miyazaki, T., Wolf, P., Tourne, S., Waltzinger, C., Dierich, A., Barois, N., Ploegh, H., Benoist, C. and Mathis, D., Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 1996. 84: 531-541.
20. Kropshofer, H., Arndt, S. O., Moldenhauer, G., Hämmerling, G. J. and Vogt, A. B., HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH. Immunity 1997. 6: 293-302.
21. Kropshofer, H., Vogt, A. B., Moldenhauer, G., Hammer, J., Blum, J. S. and Hämmerling, G. J., Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J. 1996. 15: 6144-6154.
22. Avva, R. R. and Cresswell, P., In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. Immunity 1994. 1: 763-774.
23. Stebbins, C. C., Loss, G. E., Jr., Elias, C. G., Chervonsky, A. and Sant, A. J., The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent. J. Exp. Med. 1995. 181: 223-234.
24. k class II molecules in human APC containing deleted or mutated HLA DM genes. J. Immunol. 1994. 153: 5382-5392.
25. Sette, A., Southwood, S., Miller, J. and Appella, E., Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II. J. Exp. Med. 1995. 181: 677-683.
26. Kropshofer, H., Hämmerling, G. J. and Vogt, A. B., How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest? Immunol. Today 1997. 18: 77-82.
27. Fung-Leung, W. P., Surh, C. D., Liljedahl, M., Pang, J., Leturcq, D., Peterson, P. A., Webb, S. R. and Karlsson, S., Antigen presentation and T cell development in H-2M deficient mice. Science 1996. 271: 1278-1281.
28. Martin, W. D., Hicks, G. G., Mendiratta, S. K., Leva, H. I., Ruley, H. E. and Van Kaer, L., H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 1996. 84: 543-550.
29. Le Meur, M., Gerlinger, P., Benoist, C. and Mathis, D., Correcting an immune-response deficiency by creating E alpha gene transgenic mice. Nature 1985. 316: 38-42.
30. k transgenic mice. J. Immunol. 1990. 144: 2865-2874.
31. Cosgrove, D., Bodmer, H., Bogue, M., Benoist, C. and Mathis, D., Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes. J. Exp. Med. 1992. 176: 629-634.
32. Braunstein, N. S., Germain, R. N., Loney, K. and Berkowitz, N., Structurally interdependent and independent regions of allelic polymorphism in class II MHC molecules. Implications for Ia function and evolution. J. Immunol. 1990. 145: 1635-1645.
33. Le Meur, M., Waltzinger, C., Gerlinger, P., Benoist, C. and Mathis, D., Restricted assembly of MHC class II molecules in transgenic mice. J. Immunol. 1989. 142: 323-327.
34. Bodmer, H., Viville, S., Benoist, C. and Mathis, D., Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain. Science 1994. 263: 1284-1286.
35. Momburg, F., Fuchs, S., Drexler, J., Busch, R., Post, M., Hämmerling, G. J. and Adorini, L., Epitope-specific enhancement of antigen presentation by invariant chain. J. Exp. Med. 1993. 178: 1453-1458.
36. Nadimi, F., Moreno, J., Momburg, F., Heuser, A., Fuchs, S., Adorini, L. and Hämmerling, G. J., Antigen presentation of hen egg-white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II-associated invariant chain. Eur. J. Immunol. 1991. 21: 1255-1263.
37. Swier, K. and Miller, J., Invariant chain-independent antigen presentation depends primarily upon the pool of newly synthesized MHC class II molecules. J. Immunol. 1995. 155: 1851-1861.
38. Germain, R. N. and Hendrix, L. R., MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding. Nature 1991. 353: 134-139.
39. Rudensky, A., Preston-Hurlburt, P., Hong, S. C., Barlow, A. and Janeway, C. A., Jr., Sequence analysis of peptides bound to MHC class II molecules [see comments]. Nature 1991. 353: 622-627.
40. Kropshofer, H., Vogt, A. B. and Hämmerling, G. J., Structural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide binding. Proc. Natl. Acad. Sci. USA 1995. 92: 8313-8317.
41. Urban, R. G., Chicz, R. M. and Strominger, J. L., Selective release of some invariant chain-derived peptides from HLA-DR1 molecules at endosomal pH. J. Exp. Med. 1994. 180: 751-755.
42. Landais, D., Beck, B. N., Buerstedde, J.-M., Degraw, S., Klein, D., Koch, N., Murphy, D., Pierres, M., Tada, T., Yamamoto, K., Benoist, C. and Mathis, D., The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants. J. Immunol. 1986. 137: 3002-3006.
43. Schafer, P. H., Green, J. M., Malapati, S., Gu, L. and Pierce, S. K., HLA-DM is present in one-fifth the amount of HLA-DR in the class II peptide-loading compartment where it associates with leupeptin-induced peptide (LIP)-HLA-DR complexes. J. Immunol. 1996. 157: 5487-5495.
44. Ceman, S., Rudersdorf, R., Long, E. O. and Demars, R., MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability. J. Immunol. 1992. 149: 754-761.
45. Mellins, E., Kempin, S., Smith, L., Monji, T. and Pious, D., A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex. J. Exp. Med. 1991. 174: 1607-1615.
46. Riberdy, J. M. and Cresswell, P., The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation. J. Immunol. 1992. 148: 2586-2590.
47. Peterson, M. and Miller, J., Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41. Nature 1992. 357: 596-598.
48. Tourne, S., Miyazaki, T., Wolf, P., Ploegh, H., Benoist, C. and Mathis, D., Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes. Proc. Natl. Acad. Sci. USA 1997. 94: 9255-9260.
49. Chan, S. J., Cosgrove, D., Waltzinger, C., Benoist, C. and Mathis, D., Another view of the selective model of thymocyte selection. Cell 1993. 73: 225-236.
50. Forsgren, S., Pobor, G., Coutinho, A. and Pierres, M., The role of I-A/E molecules in B lymphocyte activation. I. Inhibition of lipopolysaccharide-induced responses by monoclonal antibodies. J. Immunol. 1984. 133: 2104-2110.
51. Janeway, C. A., Jr., Conrad, P. J., Lerner, E. A., Babich, J., Wettstein, P. and Murphy, D. B., Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cell bound Ia antigens as targets of immunoregulatory T cells. J. Immunol. 1984. 132: 662-667.
52. Schwartz, R. H., Fox, B. S., Fraga, E., Chen, C. and Singh, B., The T lymphocyte response to cytochrome C. V. Determination of the minimal peptide size required for stimulation of T cell clones and assessment of the contribution of each residue beyond this size to antigenic potency. J. Immunol. 1985. 135: 2598-2608.
53. k molecule. J. Immunol. 1988. 141: 4124-4128.
54. Berg, L. J., Pullen, A. M., Fazekas de St. Groth, B., Mathis, D., Benoist, C. and Davis, M. M., Antigen/ MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 1989. 58: 1035-1046.