The transmembrane segment of invariant chain mediates binding to MHC class II molecules in a CLIP-independent manner

European Journal of Immunology

Volumn 31, Issue 3, 2001, Pages 841-850

  Castellino, Flora ^a   Han, Ricai ^a   Germain, Ronald N ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Antigen; Antigen processing; Biochemistry; Epitope; MHC

Indexed keywords

CHAPERONE; CHIMERIC PROTEIN; DETERGENT; DIMER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN; MUTANT PROTEIN; SYNTHETIC PEPTIDE; TRANSFERRIN RECEPTOR;

ALLELE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOCYTOSIS; EXON; INVARIANT CHAIN; MOUSE; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN POLYMORPHISM; RECEPTOR OCCUPANCY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; BINDING SITES; COS CELLS; DIMERIZATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; MICE; PEPTIDES; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; TRANSFECTION;

EID: 0035081835     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200103)31:3<841::AID-IMMU841>3.0.CO;2-D     Document Type: Article

References (61)

1. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain
2. Invariant chain associates with HLA class II antigens via its extracytoplasmic region
3. Implications of the invariant gamma-chain on the intracellular transport of class II histocompatibility antigens
4. Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment
5. Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules
6. Intracellular transport of class II MHC molecules directed by invariant chain
7. Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways
8. Relationship between invariant chain expression and MHC class II transport into early and late endocytic compartment
9. Mice lacking the MHC class II-associated invariant chain
10. Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression
11. The invariant chains is required for intracellular transport and function of major histocompatibility complex class II molecules
12. Association with BiP and aggregation of class II molecules synthesized in the absence of invariant chain
13. Allelic differences affecting invariant chain dependency of MHC class II subunit assembly
14. Poor loading of major histocompatibility complex class II molecules with endogenously synthesized short peptides in the absence of invariant chain
15. Invariant chain protects class II histocompatibility antigens from binding intact polypeptide in the endoplasmic reticulum
16. Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class chain peptides (CLIP)
17. The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides
18. Mapping functional regions in the lumenal domain of the class II-associated invariant chain
19. The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy
20. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
21. T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates
22. Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules
23. Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II
24. Assembly, transport, and function of MHC class II molecules
25. Interaction of MHC class II molecules with the invariant chain: Role of the invariant chain (81-90) region
26. Identification of a sequence that mediates promiscuous binding of invariant chain to MHC class II allotypes
27. Invariant chain can bind MHC class II at a site other than the peptide binding groove
28. Production of soluble MHC class II proteins with covalently bound single peptides
29. Cell surface expression of class II MHC proteins bound by a single peptide
30. On the complexity of self
31. Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1
32. Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DR
33. Expression of endogenous peptide-major histocompatibility complex class II complexes derived from invariant chain-antigen fusion proteins
34. Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules
35. An LI and ML motif in the cytoplasmic tail of the MHC-associated invariant chain mediate rapid internalization
36. Membrane protein association by potential intramembrane charge pairs
37. Transmembrane helical interactions and the assembly of the T cell receptor complex
38. A subunit common to an IgG Fc receptor and the T-cell receptor mediate assembly through different interactions
39. Role of transmembrane domain interactions in the assembly of class II MHC molecules
40. A role for the transmembrane domain in the trimerization of the MHC class II-associated invariant chain
41. Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes selective cell surface expression of occupied molecules
42. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells
43. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading
44. HLA-DM induces CLIP dissociation from MHC class IIαβ dimers and facilitates peptide loading
45. Mediation by HLA-DM of dissociation of peptides from HLA-DR1
46. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
47. Editing of the HLA-DR-peptide repertoire by HLA-DM
48. Human histocompatibility leucocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs
49. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
50. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
51. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
52. A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments
53. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments
54. HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments
55. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
56. HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH
57. Interactin with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human intgral membrane protein IP90 (calnexin)
58. A shared alloantigenic determinant on IA antigens encoded by the I-A and I-E subregions: Evidence for I region gene duplication
59. Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody
60. Characterization of fragments of the murine la-associated invariant chain
61. Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains