Identification of a sequence that mediates promiscuous binding of invariant chain to MHC class II allotypes

Journal of Immunology

Volumn 160, Issue 7, 1998, Pages 3355-3362

  Siebenkotten, Ina M ^a   Carstens, Cornelia ^a   Koch, Norbert ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLOTYPE; AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; ANTIGEN BINDING; ANTIGENICITY; ARTICLE; ENDOPLASMIC RETICULUM; HUMAN; MOLECULAR INTERACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; BINDING SITES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INFLUENZA A VIRUS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PROTEIN BINDING; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; VIRAL MATRIX PROTEINS;

EID: 0032055577     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Stockinger, B., U. Pessara, R. H. Lin, J. Habicht, M. Grez, and N. Koch. 1989. A role of Ia-associated invariant chains in antigen processing and presentation. Cell 56:683.
2. Viville, S., J. Neefjes, V. Lotteau, A. Dierich, M. Lemeur, H. Ploegh, C. Benoist, and D. Mathis. 1993. Mice lacking the MHC class II-associated invariant chain. Cell 72:635.
3. + T cell selection in mice lacking invariant chain expression. J. Exp. Med. 177:1699.
4. + T cell development. Immunity 3:359.
5. Shachar, I., E. A. Elliott, B. Chasnoff, I. S. Grewal, and R. A. Flavell. 1995. Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms. Immunity 3:373.
6. + T cell function in mice lacking the p41 isoform of invariant chain. Immunity 3:385.
7. Bakke, O., and B. Dobberstein. 1990. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell 63:707.
8. Lotteau, V., L. Teyton, A. Pelereaux, T. Nilsson, L. Karlsson, S. L. Schmid, V. Quaranta, and P. A. Peterson. 1990. Intracellular transport of class II MHC molecules directed by invariant chain. Nature 348:600.
9. Lamb, C. A, J. W. Yewdell, J. R. Bennink, and P. Cresswell. 1991. Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus. Proc. Natl. Acad. Sci. USA 88:5998.
10. Mellman, I., P. Pierre, and S. Amigorena. 1995. Lonely MHC molecules seeking immunogenic peptides for meaningful relationships. Curr. Opin. Cell biol. 7:564.
11. Anderson, M. S., and J. Miller. 1992. Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. USA 89:2282.
12. Bikoff, E. K., R. N. Germain, and E. J. Robertson. 1995. Allelic differences affecting invariant chain dependency of MHC class II subunit assembly. Immunity 2:301.
13. Schaiff, W. T., K. A. Hruska, D. W. McCourt, M. Green, and B. D. Schwartz. 1992. HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells. J. Exp. Med. 176:657.
14. Germain, R. N., and A. G. Rinker, Jr. 1993. Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules. Nature 363:725.
15. Bonnerot, C., M. S. Marks, P. Cosson, E. J. Robertson, E. K. Bikoff, R. N. Germain, and J. S. Bonifacino. 1994. Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain. EMBO J. 13:934.
16. Elliott, E. A., J. R. Drake, S. Amigorena, J. Elsemore, P. Webster, I. Mellman, and R. A. Flavell. 1994. The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J. Exp. Med. 179:681.
17. Freisewinkel, I. M., K. Schenck, and N. Koch. 1993. The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides. Proc. Natl. Acad. Sci. USA 90:9703.
18. Bijlmakers, M-J., E. P. Benaroch, and H. Ploegh. 1994. Mapping functional regions in the lumenal domain of the class II-associated invariant chain. J. Exp. Med. 180:623.
19. Romagnoli, P., and R. N. Germain. 1994. The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy. J. Exp. Med. 180:1107.
20. Rammensee, H.-G., T. Friede, and S. Stevanovic. 1995. MHC ligands and peptide motifs: first listing. Immunogenetics 41:178.
21. Ghosh, P., M. Amaya, E. Mellins, and D. C. Wiley. 1995. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378:457.
22. Avva, R. R., and P. Cresswell. 1994. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. Immunity 1:763.
23. Riberdy, J. M., R. R. Avva, H. J. Geuze, and P. Cresswell. 1994. Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines. J. Cell. Biol. 125:1225.
24. Park, S.-J., S. Sadegh-Nasseri, and D. C. Wiley. 1995. Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1. Proc. Natl. Acad. Sci. USA 92:11289.
25. Morkowski, S., A. W. Goldrath, S. Eastman, L. Ramachandra, D. C. Freed, P. Whiteley, and A. Y. Rudensky. 1995. T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates. J. Exp. Med. 182:1403.
26. Sette, A., S. Southwood, J. Miller, and E. Appella. 1995. Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II. J. Exp. Med. 181:677.
27. Denzin, L. K., N. F. Robbins, C. Carboy-Newcomb, and P. Cresswell. 1994. Assembly and intracellular transport of HLA-DM and correction of the class II antigen processing defect in T2 cells. Immunity 1:595.
28. Denzin, L. K., and P. Cresswell. 1995. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82:155.
29. Sherman, M. A., D. A. Weber, and P. E. Jensen. 1995. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide. Immunity 3:197.
30. Malcherek, G., V. Gnau, G. Jung, H.-G. Rammensee, and A. Melms. 1995. Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules. J. Exp. Med. 181:527.
31. Stebbins, C. C., G. E. Loss, Jr., C. G. Elias, A. Chervonsky, and A. J. Sant. 1995. The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent. J. Exp. Med. 181:223.
32. Roche, P. A. 1995. HLA-DM: an in vivo facilitator of MHC class II peptide loading. Immunity 3:259.
33. Glimcher, L. H., B. S. Polla, A. Poljak, C. C. Morton, and D. J. McKean. 1987. Murine class II (Ia) molecules associate with human invariant chain. J. Immunol. 138:1519.
34. Okyama, H., and P. Berg. 1983. A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells. Mol. Cell. Biol. 3:280.
35. Cullen, B. R. 1987. Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol. 152:684.
36. Chu, G., H. Hayakawa, and P. Berg. 1987. Electroporation for the efficient transfection of mammalian cells with DNA. Nucl. Acids Res. 15:1311.
37. Rose, J. K., L. Bionocore, and M. A. Whitt. 1991. A new cationic liposome reagent mediating nearly quantitative transfection of animal cells. Biotechniques 10:520.
38. Mehringer, J. H., M. R. Harris, C. S. Kindle, D. W. McCourt, and S. E. Cullen. 1991. Characterization of fragments of the murine Ia-associated invariant chain. J. Immunol. 146:920.
39. Quaranta, V., O. Majdic, G. Stingl, K. Liszka, H. Honigsmann, and W. Knapp. 1984. A human Ia cytoplasmic determinant located on multiple forms of invariant chain. J. Immunol. 132:1900.
40. Koch, N., S. Koch, and G. J. Hämmerling. 1982. Ia-invariant chain detected on the lymphocyte surfaces by monoclonal antibody. Nature 299:644.
41. Watanabe, M., T. Suzuki, M. Taniguchi, and N. Shinohara. 1983. Monoclonal anti-Ia murine alloantibodies cross-reactive with the Ia-homologues of other species including human. Transplantation 36:712.
42. Pesando, J. M., and L. Graf. 1986. Differential expression of HLA-DR, -DQ, and -DP antigens on malignant B cells. J. Immunol. 136:4311.
43. Chicz, R. M., R. G. Urban, J. C. Gorga, D. A. A. Vignali, W. S. Lane, and J. L. Strominger. 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178:27.
44. Riberdy, J. M., and P. Cresswell. 1992. The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II anigen presentation. J. Immunol. 148:2586.
45. Hammer, J., P. Valsasnini, K. Tolba, D. Bolin, J. Higelin, J. Takacs, and F. Sinigaglia. 1993. Promiscuous and allele-specific anchors in HLA-DR binding peptides. Cell 74:197.
46. Nelson, C. A., S. J. Petzold, and E. R. Unanue. 1993. Identification of two distinct properties of class II major histocompatibility complex-associated peptides. Proc. Natl. Acad. Sci. USA 90:1227.
47. Adams, S., and R. E. Humphreys. 1995. Invariant chain peptides enhancing or inhibiting the presentation of antigenic peptides by major histocompatibility complex class II molecules. Eur. J. Immunol. 25:1693.
48. Kropshofer, H., A. B. Vogt, and G. J. Hämmerling. 1995. Structural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide binding. Proc. Natl. Acad. Sci. USA 92:8313.
49. Vogt, A. B., L. J. Stern, C. Amshoff, B. Dobberstein, G. J. Hämmerling, and H. Kropshofer. 1995. Interference of distinct invariant chain regions with super-antigen contact area and antigenic peptide binding groove of HLA-DR. J. Immunol. 155:4757.
50. Jasanoff, A., S-J. Park, and D. C. Wiley. 1995. Direct observation of disordered regions in the major histocompatibility complex class II-associated invariant chain. Proc. Natl. Acad. Sci. USA 92:9904.
51. Blum, J. S., and P. Cresswell. 1988. Role for intracellular proteases in the processing and transport of class II HLA antigens. Proc. Natl. Acad. Sci. USA 85: 3975.
52. Newcomb, J. R., and P. Cresswell. 1993. Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo. J. Immunol. 151:4153.
53. Mivazaki, T., P. Wolf, S. Tourne, C. Waltzinger, A. Dierich, N. Barois, H. Ploegh, C. Benoist, and D. Mathis. 1996. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 84:531.
54. Martin, W. D., G. G. Hicks, S. K. Mendiratta, H. I. Leva, H. E. Ruley, and L. Van Kaer. 1996. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84: 543.
55. Fung-Leung, W.-P., C. D. Surh, M. Liljedahl, J. Pang, D., Leturcq, P. A. Peterson, S. R. Webb, and L. Karlsson. 1996. Antigen presentation and T cell development in H2-M-deficient mice. Science 271:1278.
56. van Bergen, J., S. P. Schoenberger, F. Verreck, R. Amons, R. Offringa, and F. Koning. 1997. Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP. Proc. Natl. Acad. Sci. USA 94:7499.
57. Stimptner, P., and P. Benaroch. 1997. Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region. EMBO J. 16:5807.