Cysteinylation of MHC class II ligands: Peptide endocytosis and reduction within APC influences T cell recognition

Journal of Immunology

Volumn 166, Issue 7, 2001, Pages 4543-4551

  Haque, M A ^a   Hawes, J W ^a   Blum, J S ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC; CYSTEINE; EPITOPE; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERNALIZATION; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; REDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0035313373     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.7.4543     Document Type: Article

References (74)

1. Capture and processing of exogenous antigens for presentation on MHC molecules
2. Sequence analysis of peptides bound to MHC class II molecules
3. d
4. The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides
5. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding
6. Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment
7. Intrellular assembly and transport of endogenous peptide-MHC class II complexes
8. Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles
9. Separation of subcellular compartments containing distinct functional forms of MHC class II
10. Isolation and characterization of the intracellular MHC class II compartment
11. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
12. HLA-DM induces CLIP dissociation from MHC class 11 αβ dimers and facilitates peptide loading
13. Mediation by HLA-DM of dissociation of peptides from HLA-DR
14. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
15. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
16. Characterization of transport of newly assembled. T cell-stimulatory MHC class II-peptide complexes from MHC class II compartments to the cell surface
17. Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization
18. Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL
19. Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity
20. Recognition of peptides that are immunopathogenic but cryptic: Mechanisms that allow lymphocytes sensitized against cryptic peptides to initiate pathogenic autoimmune processes
21. + T cells during an acute virus infection
22. Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: Pathway of presentation and regulation by cytokines
23. Induction of Epstein-Barr virus-specific cytotoxic T-lymphocyte responses using dendritic cells pulsed with EBNA-3A peptides or UV-inactivated, recombinant EBNA-3A vaccinia virus
24. Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells
25. Antigen capture, processing, and presentation by dendritic cells: Recent cell biological studies
26. Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing
27. Exogenously provided peptides fail to complex with intracellular class II molecules for presentation by antigen-presenting cells
28. Processing of a minimal antigenic peptide alters its interaction with MHC molecules
29. 74-90)
30. Reduction of disulfide bonds during antigen processing: Evidence from a thiol-dependent insulin determinant
31. d molecules
32. Exogenously provided peptides of a self-antigen can be processed into forms that are recognized by self-T cells
33. Endocytic recycling is required for the presentation of an exogenous peptide via MHC class II molecules
34. Drug-induced inhibition of insulin recognition by T-cells: The antirheumatic drug aurothiomalate inhibits MHC binding of insulin peptide
35. Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants
36. The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition
37. Posttranslational side chain modification of a viral epitope results in diminished recognition by specific T cells
38. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation
39. Characterization of fibroblasts with a unique defect in processing antigens with disulfide bonds
40. Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome
41. Structural requirements for recognition of the HLA-Dw14 class II epitope: A key HLA determinant associated with rheumatoid arthritis
42. Role of APC in the selection of immunodominant T cell epitopes
43. Exploration of requirements for peptide binding to HLA DRB1 0101 and DRB1 0401
44. Binding of labeled influenza matrix peptide to HLA-DR in living B lymphoid cells
45. Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH
46. Antigen presentation mediated by recycling of surface HLA-DR molecules
47. Recycling of the asialoglycoprotein receptor and the effect of lysosomotrophic amines in hepatoma cells
48. Sorting of endocytosed transferrin and asialoglycoprotein occurs immediately after internalization in HepG2 cells
49. Endocytosis and degradation mediated by the asialoglycoprotein receptor in isolated rat hepatocytes
50. Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: Receptor pathway
51. Effects of temperature, pH elevators, and energy production inhibitors on horseradish peroxidase transport through endocytic vesicles
52. Microtubules are involved in transport of macromolecules by vesicles in cultured bovine aortic endothelial cells
53. Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface
54. Acidification of the endocytic and exocytic pathways
55. Membrane interactions influence the peptide binding behavior of DRI
56. Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC
57. Extracellular antigen processing and presentation by immature dendritic cells
58. Structures of an MHC class II molecule with covalently bound single peptides
59. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas: Lack of independent antigen and H-2 recognition
60. Identification of an immunodominant peptide of Her-2/neo protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines
61. The HLA-A*0101-restricted HY minor histocompatibility antigen originates from DFFRY and contains a cysteinylated cysteine residue as identified by a novel mass spectrometric technique
62. MHC-peptide binding: Dimers of cysteine-containing nonapeptides bind with high affinity to HLA-A2.1 class I molecules
63. Processing and presentation of insulin. I. Analysis of immunogenic peptides and processing requirements for insulin A loop-specific T cells
64. Reduction of disulfide bonds within lysosomes is a key step in antigen processing
65. Processing by accessory cells for presentation to murine T cells of apamin, a disulfide-bonded 18 amino acid peptide
66. Posttranslational modification of the glycosylation inhibiting factor (GIF) gene product generates bioactive GIF
67. Amino acid exchange and covalent modification by cysteine and glutathione explain isoforms of fatty acid-binding protein occurring in bovine liver
68. Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: Interaction of the 1-1382 and 1383-2035 fragments
69. Albumin banks peninsula: A new termination variant characterized by etectrospray mass spectrometry
70. Several common HLA-DR types share largely overlapping peptide binding repertoires
71. Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: Implications for tumor vaccine development
72. Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a γ-interferon-inducible lysosomal thiol reductase (GILT)
73. Binding to la protects an immunogenic peptide from proteolytic degradation
74. Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles