Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class ii molecules after invariant chain removal

Journal of Experimental Medicine

Volumn 188, Issue 11, 1998, Pages 2139-2149

  Ceman, Stephanie ^a   Wu, Shenhong ^a   Jardetzky, Theodore S ^b   Sant, Andrea J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Hydrogen bond; Invariant chain; Major histocompatibility complex class II; Peptide; Proteolysis

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MUTANT PROTEIN; PROTEINASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL SURFACE; CHO CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOSOME; GENETIC TRANSFECTION; GOLGI COMPLEX; HYDROGEN BOND; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; GENES, MHC CLASS II; HISTOCOMPATIBILITY ANTIGENS CLASS II; HYDROGEN; MICE; MUTATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031744254     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.11.2139     Document Type: Article

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