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Volumn 249, Issue 1-2, 2000, Pages 17-30

Transforming growth factor β signaling mediators and modulators

Author keywords

Receptor serine kinases; Signal transduction; Smads; Transcription factors; Tumor suppressors

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CALMODULIN; PROTEIN; PROTEIN INHIBITOR; PROTEIN SERINE KINASE; RECEPTOR; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; VITAMIN D RECEPTOR;

EID: 0034673972     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00162-1     Document Type: Review
Times cited : (153)

References (108)
  • 1
    • 0033521032 scopus 로고    scopus 로고
    • C-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with smads
    • 269-35 277
    • Akiyoshi S., Inoue H., Hanai J., Kusanagi K., Nemoto N., Miyazono K., Kawabata M. c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with smads. J. Biol. Chem. 274:1999;35 269-35 277.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35
    • Akiyoshi, S.1    Inoue, H.2    Hanai, J.3    Kusanagi, K.4    Nemoto, N.5    Miyazono, K.6    Kawabata, M.7
  • 2
    • 0028953810 scopus 로고
    • Transforming growth factor β and cell cycle regulation
    • Alexandrow M.G., Moses H.L. Transforming growth factor β and cell cycle regulation. Cancer Res. 55:1995;1452-1457.
    • (1995) Cancer Res. , vol.55 , pp. 1452-1457
    • Alexandrow, M.G.1    Moses, H.L.2
  • 3
    • 0029072998 scopus 로고
    • The Drosophila schnurri gene acts in the Dpp/TGF β signaling pathway and encodes a transcription factor homologous to the human MBP family
    • Arora K., Dai H., Kazuko S.G., Jamal J., O'Connor M.B., Letsou A., Warrior R. The Drosophila schnurri gene acts in the Dpp/TGF β signaling pathway and encodes a transcription factor homologous to the human MBP family. Cell. 81:1995;781-790.
    • (1995) Cell , vol.81 , pp. 781-790
    • Arora, K.1    Dai, H.2    Kazuko, S.G.3    Jamal, J.4    O'Connor, M.B.5    Letsou, A.6    Warrior, R.7
  • 6
    • 0029829230 scopus 로고    scopus 로고
    • A novel mesoderm inducer, Madr2 functions in the activin signal transduction pathway
    • Baker J.C., Harland R.M. A novel mesoderm inducer, Madr2 functions in the activin signal transduction pathway. Genes Dev. 10:1996;1880-1889.
    • (1996) Genes Dev. , vol.10 , pp. 1880-1889
    • Baker, J.C.1    Harland, R.M.2
  • 8
    • 0033605559 scopus 로고    scopus 로고
    • MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
    • Brown J.D., DiChiara M.R., Anderson K.R., Gimbrone M.A. Jr, Topper J.N. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J. Biol. Chem. 274:1999;8797-8805.
    • (1999) J. Biol. Chem. , vol.274 , pp. 8797-8805
    • Brown, J.D.1    Dichiara, M.R.2    Anderson, K.R.3    Gimbrone M.A., Jr.4    Topper, J.N.5
  • 9
    • 0028359376 scopus 로고
    • Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin
    • Cárcamo J., Weis F.M., Ventura F., Wieser R., Wrana J.L., Attisano L., Massagué J. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin. Mol. Cell. Biol. 14:1994;3810-3821.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3810-3821
    • Cárcamo, J.1    Weis, F.M.2    Ventura, F.3    Wieser, R.4    Wrana, J.L.5    Attisano, L.6    Massagué, J.7
  • 10
    • 0031027637 scopus 로고    scopus 로고
    • A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis
    • Chang C., Wilson P.A., Mathews L.S., Hemmati-Brivanlou A. A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis. Development. 124:1997;827-837.
    • (1997) Development , vol.124 , pp. 827-837
    • Chang, C.1    Wilson, P.A.2    Mathews, L.S.3    Hemmati-Brivanlou, A.4
  • 11
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGF-β signalling
    • Chen X., Rubock M.J., Whitman M. A transcriptional partner for MAD proteins in TGF-β signalling. Nature. 383:1996;691-696.
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 15
    • 0031812292 scopus 로고    scopus 로고
    • The Drosophila gene Medea reveals the requirement for different classes of Smads in dpp signaling
    • Das P., Maduzia L.L., Wang H., Finelli A.L., Cho S.H., Smith M.M., Padgett R.W. The Drosophila gene Medea reveals the requirement for different classes of Smads in dpp signaling. Development. 125:1998;1519-1528.
    • (1998) Development , vol.125 , pp. 1519-1528
    • Das, P.1    Maduzia, L.L.2    Wang, H.3    Finelli, A.L.4    Cho, S.H.5    Smith, M.M.6    Padgett, R.W.7
  • 16
    • 0029073142 scopus 로고
    • Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto M.B., Li Y., Panus J.F., Howe D.J., Xiong Y., Wang X.F. Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA. 92:1995;5545-5549.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 18
    • 0033602186 scopus 로고    scopus 로고
    • A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3
    • Dennler S., Huet S., Gauthier J.M. A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncogene. 18:1999;1643-1648.
    • (1999) Oncogene , vol.18 , pp. 1643-1648
    • Dennler, S.1    Huet, S.2    Gauthier, J.M.3
  • 21
    • 0027373733 scopus 로고
    • The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development
    • Estevez M., Attisano L., Wrana J.L., Albert P.S., Massagué J., Riddle D.L. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature. 365:1993;644-649.
    • (1993) Nature , vol.365 , pp. 644-649
    • Estevez, M.1    Attisano, L.2    Wrana, J.L.3    Albert, P.S.4    Massagué, J.5    Riddle, D.L.6
  • 22
    • 0030926005 scopus 로고    scopus 로고
    • A kinase subdomain of transforming growth factor-β type I receptor determines the TGF-β intracellular signaling specificity
    • Feng X.H., Derynck R. A kinase subdomain of transforming growth factor-β type I receptor determines the TGF-β intracellular signaling specificity. EMBO J. 16:1997;3912-3923.
    • (1997) EMBO J. , vol.16 , pp. 3912-3923
    • Feng, X.H.1    Derynck, R.2
  • 23
    • 0032528236 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation
    • Feng X.H., Zhang Y., Wu R.Y., Derynck R. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation. Genes Dev. 12:1998;2153-2163.
    • (1998) Genes Dev. , vol.12 , pp. 2153-2163
    • Feng, X.H.1    Zhang, Y.2    Wu, R.Y.3    Derynck, R.4
  • 24
    • 0027332995 scopus 로고
    • Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor
    • Franzén P., ten Dijke P., Ichijo H., Yamashita H., Schulz P., Heldin C.-H., Miyazono K. Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor. Cell. 75:1993;681-692.
    • (1993) Cell , vol.75 , pp. 681-692
    • Franzén, P.1    Ten Dijke, P.2    Ichijo, H.3    Yamashita, H.4    Schulz, P.5    Heldin, C.-H.6    Miyazono, K.7
  • 25
    • 0025281396 scopus 로고
    • Daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase
    • Georgi L.L., Albert P.S., Riddle D.L. daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Cell. 61:1990;635-645.
    • (1990) Cell , vol.61 , pp. 635-645
    • Georgi, L.L.1    Albert, P.S.2    Riddle, D.L.3
  • 26
    • 0029940972 scopus 로고    scopus 로고
    • Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily
    • Graff J.M., Bansal A., Melton D.A. Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily. Cell. 85:1996;479-487.
    • (1996) Cell , vol.85 , pp. 479-487
    • Graff, J.M.1    Bansal, A.2    Melton, D.A.3
  • 27
    • 0028990126 scopus 로고
    • Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1
    • Greider N.C., Nellen D., Burke R., Basler K., Affolter M. Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. Cell. 1995:1995;791-800.
    • (1995) Cell , vol.1995 , pp. 791-800
    • Greider, N.C.1    Nellen, D.2    Burke, R.3    Basler, K.4    Affolter, M.5
  • 30
    • 0031964859 scopus 로고    scopus 로고
    • Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    • Hata A., Lagna G., Massagué J., Hemmati-Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 12:1998;186-197.
    • (1998) Genes Dev. , vol.12 , pp. 186-197
    • Hata, A.1    Lagna, G.2    Massagué, J.3    Hemmati-Brivanlou, A.4
  • 31
    • 0034695506 scopus 로고    scopus 로고
    • OAZ uses distinct DNA- And protein-binding zinc fingers in separate BMP- Smad and Olf signaling pathways
    • Hata A., Seoane J., Lagna G., Montalvo E., Hemmati-Brivanlou A., Massagué J. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP- Smad and Olf signaling pathways. Cell. 100:2000;229-240.
    • (2000) Cell , vol.100 , pp. 229-240
    • Hata, A.1    Seoane, J.2    Lagna, G.3    Montalvo, E.4    Hemmati-Brivanlou, A.5    Massagué, J.6
  • 34
    • 0032191407 scopus 로고    scopus 로고
    • Synergistic cooperation of TFE3 and smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene
    • Hua X., Liu X., Ansari D.O., Lodish H.F. Synergistic cooperation of TFE3 and smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev. 12:1998;3084-3095.
    • (1998) Genes Dev. , vol.12 , pp. 3084-3095
    • Hua, X.1    Liu, X.2    Ansari, D.O.3    Lodish, H.F.4
  • 35
    • 0033539612 scopus 로고    scopus 로고
    • Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: Interactions of promoter DNA, transcription factor muE3 and Smad proteins
    • 130-13 135
    • Hua X., Miller Z.A., Wu G., Shi Y., Lodish H.F. Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3 and Smad proteins. Proc. Natl. Acad. Sci. USA. 96:1999;13 130-13 135.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13
    • Hua, X.1    Miller, Z.A.2    Wu, G.3    Shi, Y.4    Lodish, H.F.5
  • 37
    • 0032527756 scopus 로고    scopus 로고
    • TGF-β-stimulated cooperation of smad proteins with the coactivators CBP/p300
    • Janknecht R., Wells N.J., Hunter T. TGF-β-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 12:1998;2114-2119.
    • (1998) Genes Dev. , vol.12 , pp. 2114-2119
    • Janknecht, R.1    Wells, N.J.2    Hunter, T.3
  • 38
    • 0028931238 scopus 로고
    • Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-β receptor
    • Kawabata M., Chytil A., Moses H.L. Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-β receptor. J. Biol. Chem. 270:1995;5625-5630.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5625-5630
    • Kawabata, M.1    Chytil, A.2    Moses, H.L.3
  • 39
    • 0030872367 scopus 로고    scopus 로고
    • Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentalplegic
    • Kim J., Johnson K., Chen H.J., Carroll S., Laughon A. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentalplegic. Nature. 388:1997;304-308.
    • (1997) Nature , vol.388 , pp. 304-308
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 40
    • 0028180315 scopus 로고
    • The TGF-β superfamily: New members, new receptors and new genetic tests of function in different organisms
    • Kingsley D.M. The TGF-β superfamily: new members, new receptors and new genetic tests of function in different organisms. Genes Dev. 8:1994;133-146.
    • (1994) Genes Dev. , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 41
    • 0030773834 scopus 로고    scopus 로고
    • Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
    • Kretzschmar M., Doody J., Massagué J. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1. Nature. 389:1997;618-622.
    • (1997) Nature , vol.389 , pp. 618-622
    • Kretzschmar, M.1    Doody, J.2    Massagué, J.3
  • 42
    • 0030911104 scopus 로고    scopus 로고
    • The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
    • Kretzschmar M., Liu F., Hata A., Doody J., Massagué J. The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11:1997;984-995.
    • (1997) Genes Dev. , vol.11 , pp. 984-995
    • Kretzschmar, M.1    Liu, F.2    Hata, A.3    Doody, J.4    Massagué, J.5
  • 43
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras
    • Kretzschmar M., Doody J., Timokhina I., Massagué J. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev. 13:1999;804-816.
    • (1999) Genes Dev. , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massagué, J.4
  • 44
    • 0032589736 scopus 로고    scopus 로고
    • Specificity of TGFβ signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans
    • Krishna S., Maduzia L.L., Padgett R.W. Specificity of TGFβ signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans. Development. 126:1999;251-260.
    • (1999) Development , vol.126 , pp. 251-260
    • Krishna, S.1    Maduzia, L.L.2    Padgett, R.W.3
  • 45
    • 0032110463 scopus 로고    scopus 로고
    • Smad2 and Smad3 positively and negatively regulate TGF β-dependent transcription through the forkhead DNA-binding protein FAST2
    • Labbe E., Silvestri C., Hoodless P.A., Wrana J.L., Attisano L. Smad2 and Smad3 positively and negatively regulate TGF β-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell. 2:1998;109-120.
    • (1998) Mol. Cell , vol.2 , pp. 109-120
    • Labbe, E.1    Silvestri, C.2    Hoodless, P.A.3    Wrana, J.L.4    Attisano, L.5
  • 46
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
    • Lagna G., Hata A., Hemmati-Brivanlou A., Massagué J. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature. 383:1996;832-836.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massagué, J.4
  • 47
    • 0027465862 scopus 로고
    • A positive role for histone acetylation in transcription factor access to nucleosomal DNA
    • Lee D.Y., Hayes J.J., Pruss D., Wolffe A.P. A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell. 72:1993;73-84.
    • (1993) Cell , vol.72 , pp. 73-84
    • Lee, D.Y.1    Hayes, J.J.2    Pruss, D.3    Wolffe, A.P.4
  • 48
    • 0026537831 scopus 로고
    • Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
    • Lin H.Y., Wang X.-F., Ng-Eaton E., Weinberg R.A., Lodish H.F. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell. 68:1992;775-785.
    • (1992) Cell , vol.68 , pp. 775-785
    • Lin, H.Y.1    Wang, X.-F.2    Ng-Eaton, E.3    Weinberg, R.A.4    Lodish, H.F.5
  • 50
    • 0030690337 scopus 로고    scopus 로고
    • Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
    • Liu F., Pouponnot C., Massagué J. Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes Dev. 11:1997;3157-3167.
    • (1997) Genes Dev. , vol.11 , pp. 3157-3167
    • Liu, F.1    Pouponnot, C.2    Massagué, J.3
  • 51
    • 0033257926 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of TGF-β-activated Smad2
    • Lo R.S., Massagué J. Ubiquitin-dependent degradation of TGF-β-activated Smad2. Nat. Cell. Biol. 1:1999;472-478.
    • (1999) Nat. Cell. Biol. , vol.1 , pp. 472-478
    • Lo, R.S.1    Massagué, J.2
  • 52
    • 0032481351 scopus 로고    scopus 로고
    • The L3 loop: A structural motif determining specific interactions between SMAD proteins and TGF-β receptors
    • Lo R.S., Chen Y.G., Shi Y., Pavletich N.P., Massagué J. The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-β receptors. EMBO J. 17:1998;996-1005.
    • (1998) EMBO J. , vol.17 , pp. 996-1005
    • Lo, R.S.1    Chen, Y.G.2    Shi, Y.3    Pavletich, N.P.4    Massagué, J.5
  • 53
    • 0033200361 scopus 로고    scopus 로고
    • The Ski oncoprotein interacts with the Smad proteins to repress TGFβ signaling
    • Luo K., Stroschein S.L., Wang W., Chen D., Martens E., Zhou S., Zhou Q. The Ski oncoprotein interacts with the Smad proteins to repress TGFβ signaling. Genes Dev. 13:1999;2196-2206.
    • (1999) Genes Dev. , vol.13 , pp. 2196-2206
    • Luo, K.1    Stroschein, S.L.2    Wang, W.3    Chen, D.4    Martens, E.5    Zhou, S.6    Zhou, Q.7
  • 54
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling
    • Macias-Silva M., Abdollah S., Hoodless P.A., Pirone R., Attisano L., Wrana J.L. MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell. 87:1996;1215-1224.
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macias-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 55
    • 0025222517 scopus 로고
    • The transforming growth factor-β family
    • Massagué J. The transforming growth factor-β family. Annu. Rev. Cell. Biol. 6:1990;597-641.
    • (1990) Annu. Rev. Cell. Biol. , vol.6 , pp. 597-641
    • Massagué, J.1
  • 56
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massagué J. TGF-β signal transduction. Annu. Rev. Biochem. 67:1998;753-791.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massagué, J.1
  • 57
    • 0025905181 scopus 로고
    • Expression cloning of an activin receptor, a predicted transmembrane serine kinase
    • Mathews L.S., Vale W.W. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell. 65:1991;973-982.
    • (1991) Cell , vol.65 , pp. 973-982
    • Mathews, L.S.1    Vale, W.W.2
  • 58
    • 0032499789 scopus 로고    scopus 로고
    • Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
    • Moustakas A., Kardassis D. Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc. Natl. Acad. Sci. USA. 95:1998;6733-6738.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6733-6738
    • Moustakas, A.1    Kardassis, D.2
  • 62
    • 0031866634 scopus 로고    scopus 로고
    • Smad6 functions as an intracellular antagonist of some TGF-β family members during Xenopus embryogenesis
    • Nakayama T., Gardner H., Berg L.K., Christian J.L. Smad6 functions as an intracellular antagonist of some TGF-β family members during Xenopus embryogenesis. Genes Cells. 3:1998;387-394.
    • (1998) Genes Cells , vol.3 , pp. 387-394
    • Nakayama, T.1    Gardner, H.2    Berg, L.K.3    Christian, J.L.4
  • 63
    • 0033214670 scopus 로고    scopus 로고
    • E1A inhibits transforming growth factor-β signaling through binding to Smad proteins
    • 716-28 723
    • Nishihara A., Hanai J., Imamura T., Miyazono K., Kawabata M. E1A inhibits transforming growth factor-β signaling through binding to Smad proteins. J. Biol. Chem. 274:1999;28 716-28 723.
    • (1999) J. Biol. Chem. , vol.274 , pp. 28
    • Nishihara, A.1    Hanai, J.2    Imamura, T.3    Miyazono, K.4    Kawabata, M.5
  • 64
    • 0033985464 scopus 로고    scopus 로고
    • TGFβ-related pathways: Roles in Caenorhabditis elegans development
    • Patterson G.I., Padgett R.W. TGFβ-related pathways: roles in Caenorhabditis elegans development. Trends Genet. 16:2000;27-33.
    • (2000) Trends Genet. , vol.16 , pp. 27-33
    • Patterson, G.I.1    Padgett, R.W.2
  • 65
    • 0030776478 scopus 로고    scopus 로고
    • The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway
    • Patterson G.I., Koweek A., Wong A., Liu Y., Ruvkun G. The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 11:1997;2679-2690.
    • (1997) Genes Dev. , vol.11 , pp. 2679-2690
    • Patterson, G.I.1    Koweek, A.2    Wong, A.3    Liu, Y.4    Ruvkun, G.5
  • 66
    • 0032483493 scopus 로고    scopus 로고
    • Physical and functional interaction of SMADs and p300/CBP
    • 865-22 868
    • Pouponnot C., Jayaraman L., Massagué J. Physical and functional interaction of SMADs and p300/CBP. J. Biol. Chem. 273:1998;22 865-22 868.
    • (1998) J. Biol. Chem. , vol.273 , pp. 22
    • Pouponnot, C.1    Jayaraman, L.2    Massagué, J.3
  • 67
    • 0033564526 scopus 로고    scopus 로고
    • TGF-β family signal transduction in Drosophila development: From Mad to Smads
    • Raftery L.A., Sutherland D.J. TGF-β family signal transduction in Drosophila development: from Mad to Smads. Dev. Biol. 210:1999;251-268.
    • (1999) Dev. Biol. , vol.210 , pp. 251-268
    • Raftery, L.A.1    Sutherland, D.J.2
  • 68
    • 0028893294 scopus 로고
    • Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila
    • Raftery L.A., Twombly V., Wharton K., Gelbart W.M. Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics. 139:1995;241-254.
    • (1995) Genetics , vol.139 , pp. 241-254
    • Raftery, L.A.1    Twombly, V.2    Wharton, K.3    Gelbart, W.M.4
  • 69
    • 0000116653 scopus 로고
    • The transforming growth factor-βs
    • M.B. Sporn, & A.B. Roberts. Berlin: Springer
    • Roberts A.B., Sporn M.B. The transforming growth factor-βs. Sporn M.B., Roberts A.B. Peptide Growth Factors and Their Receptors. 1990;419-472 Springer, Berlin.
    • (1990) Peptide Growth Factors and Their Receptors , pp. 419-472
    • Roberts, A.B.1    Sporn, M.B.2
  • 70
    • 0027503601 scopus 로고
    • Physiological actions and clinical applications of transforming growth factor-β
    • Roberts A.B., Sporn M.B. Physiological actions and clinical applications of transforming growth factor-β Growth Factors. 8:1993;1-9.
    • (1993) Growth Factors , vol.8 , pp. 1-9
    • Roberts, A.B.1    Sporn, M.B.2
  • 71
    • 0030058914 scopus 로고    scopus 로고
    • Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor β pathway components
    • Savage C., Das P., Finelli A.L., Townsend S.R., Sun C.Y., Baird S.E., Padgett R.W. Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor β pathway components. Proc. Natl. Acad. Sci. USA. 93:1996;790-794.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 790-794
    • Savage, C.1    Das, P.2    Finelli, A.L.3    Townsend, S.R.4    Sun, C.Y.5    Baird, S.E.6    Padgett, R.W.7
  • 72
    • 0028940853 scopus 로고
    • Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
    • Sekelsky J.J., Newfeld S.J., Raftery L.A., Chartoff E.H., Gelbart W.M. Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics. 139:1995;1347-1358.
    • (1995) Genetics , vol.139 , pp. 1347-1358
    • Sekelsky, J.J.1    Newfeld, S.J.2    Raftery, L.A.3    Chartoff, E.H.4    Gelbart, W.M.5
  • 73
    • 0033532057 scopus 로고    scopus 로고
    • Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling
    • 711-13 717
    • Shi X., Yang X., Chen D., Chang Z., Cao X. Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. J. Biol. Chem. 274:1999;13 711-13 717.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13
    • Shi, X.1    Yang, X.2    Chen, D.3    Chang, Z.4    Cao, X.5
  • 74
    • 0030837455 scopus 로고    scopus 로고
    • A structural basis for mutational inactivation of the tumour suppressor Smad4
    • Shi Y., Hata A., Lo R.S., Massagué J., Pavletich N.P. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature. 388:1997;87-93.
    • (1997) Nature , vol.388 , pp. 87-93
    • Shi, Y.1    Hata, A.2    Lo, R.S.3    Massagué, J.4    Pavletich, N.P.5
  • 75
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling
    • Shi Y., Wang Y.F., Jayaraman L., Yang H., Massagué J., Pavletich N.P. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling. Cell. 94:1998;585-594.
    • (1998) Cell , vol.94 , pp. 585-594
    • Shi, Y.1    Wang, Y.F.2    Jayaraman, L.3    Yang, H.4    Massagué, J.5    Pavletich, N.P.6
  • 77
    • 0029959774 scopus 로고    scopus 로고
    • Phosphorylation of Ser165 in TGF-β type I receptor modulates TGF-β1-induced cellular responses
    • Souchelnytskyi S., ten Dijke P., Miyazono K., Heldin C.H. Phosphorylation of Ser165 in TGF-β type I receptor modulates TGF-β1-induced cellular responses. EMBO J. 15:1996;6231-6240.
    • (1996) EMBO J. , vol.15 , pp. 6231-6240
    • Souchelnytskyi, S.1    Ten Dijke, P.2    Miyazono, K.3    Heldin, C.H.4
  • 78
    • 0033595704 scopus 로고    scopus 로고
    • Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein
    • Stroschein S.L., Wang W., Zhou S., Zhou Q., Luo K. Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein. Science. 286:1999;771-774.
    • (1999) Science , vol.286 , pp. 771-774
    • Stroschein, S.L.1    Wang, W.2    Zhou, S.3    Zhou, Q.4    Luo, K.5
  • 79
    • 0033213606 scopus 로고    scopus 로고
    • Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signaling
    • Sun Y., Liu X., Eaton E.N., Lane W.S., Lodish H.F., Weinberg R.A. Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signaling. Mol. Cell. 4:1999;499-509.
    • (1999) Mol. Cell , vol.4 , pp. 499-509
    • Sun, Y.1    Liu, X.2    Eaton, E.N.3    Lane, W.S.4    Lodish, H.F.5    Weinberg, R.A.6
  • 80
    • 0033607240 scopus 로고    scopus 로고
    • SnoN and ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling
    • 442-12 447
    • Sun Y., Liu X., Ng-Eaton E., Lodish H.F., Weinberg R.A. SnoN and ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling. Proc. Natl. Acad. Sci. USA. 96:1999;12 442-12 447.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12
    • Sun, Y.1    Liu, X.2    Ng-Eaton, E.3    Lodish, H.F.4    Weinberg, R.A.5
  • 81
    • 0027328191 scopus 로고
    • Activin receptor-like kinases: A novel subclass of cell-surface receptors with predicted serine/threonine kinase activity
    • Ten Dijke P., Ichijo H., Franzén P., Schulz P., Saras J., Toyoshima H., Heldin C.H., Miyazono K. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene. 8:1993;2879-2887.
    • (1993) Oncogene , vol.8 , pp. 2879-2887
    • Ten Dijke, P.1    Ichijo, H.2    Franzén, P.3    Schulz, P.4    Saras, J.5    Toyoshima, H.6    Heldin, C.H.7    Miyazono, K.8
  • 83
    • 0032957753 scopus 로고    scopus 로고
    • The DAF-3 smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx
    • Thatcher J.D., Haun C., Okkema P.G. The DAF-3 smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development. 126:1999;97-107.
    • (1999) Development , vol.126 , pp. 97-107
    • Thatcher, J.D.1    Haun, C.2    Okkema, P.G.3
  • 85
    • 0032482946 scopus 로고    scopus 로고
    • CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells
    • Topper J.N., DiChiara M.R., Brown J.D., Williams A.J., Falb D., Collins T., Gimbrone M.A. Jr. CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. USA. 95:1998;9506-9511.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9506-9511
    • Topper, J.N.1    Dichiara, M.R.2    Brown, J.D.3    Williams, A.J.4    Falb, D.5    Collins, T.6    Gimbrone M.A., Jr.7
  • 86
    • 0032428684 scopus 로고    scopus 로고
    • SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor
    • Tsukazaki T., Chiang T.A., Davison A.F., Attisano L., Wrana J.L. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell. 95:1998;779-791.
    • (1998) Cell , vol.95 , pp. 779-791
    • Tsukazaki, T.1    Chiang, T.A.2    Davison, A.F.3    Attisano, L.4    Wrana, J.L.5
  • 87
  • 88
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β/SMAD signalling by the interferon-gamma/STAT pathway
    • Ulloa L., Doody J., Massagué J. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-gamma/STAT pathway. Nature. 397:1999;710-713.
    • (1999) Nature , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massagué, J.3
  • 89
    • 0032414597 scopus 로고    scopus 로고
    • A mouse homologue of FAST-1 transduces TGFβ superfamily signals and is expressed during early embryogenesis
    • Weisberg E., Winnier G.E., Chen X., Farnsworth C.L., Hogan B.L., Whitman M. A mouse homologue of FAST-1 transduces TGFβ superfamily signals and is expressed during early embryogenesis. Mech. Dev. 79:1998;17-27.
    • (1998) Mech. Dev. , vol.79 , pp. 17-27
    • Weisberg, E.1    Winnier, G.E.2    Chen, X.3    Farnsworth, C.L.4    Hogan, B.L.5    Whitman, M.6
  • 90
    • 0032529159 scopus 로고    scopus 로고
    • Smads and early developmental signaling by the TGFβ superfamily
    • Whitman M. Smads and early developmental signaling by the TGFβ superfamily. Genes Dev. 12:1998;2445-2462.
    • (1998) Genes Dev. , vol.12 , pp. 2445-2462
    • Whitman, M.1
  • 91
    • 0030037438 scopus 로고    scopus 로고
    • Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
    • Wiersdorff V., Lecuit T., Cohen S.M., Mlodzik M. Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development. 122:1996;2153-2162.
    • (1996) Development , vol.122 , pp. 2153-2162
    • Wiersdorff, V.1    Lecuit, T.2    Cohen, S.M.3    Mlodzik, M.4
  • 92
    • 0029022221 scopus 로고
    • GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex
    • Wieser R., Wrana J.L., Massagué J. GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex. EMBO J. 14:1995;2199-2208.
    • (1995) EMBO J. , vol.14 , pp. 2199-2208
    • Wieser, R.1    Wrana, J.L.2    Massagué, J.3
  • 93
    • 0029985652 scopus 로고    scopus 로고
    • Formation and activation by phosphorylation of activin receptor complexes
    • Willis S.A., Zimmerman C.M., Li L., Mathews L.S. Formation and activation by phosphorylation of activin receptor complexes. Mol. Endocrinol. 10:1996;367-379.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 367-379
    • Willis, S.A.1    Zimmerman, C.M.2    Li, L.3    Mathews, L.S.4
  • 94
    • 0029869172 scopus 로고    scopus 로고
    • Histone deacetylase: A regulator of transcription
    • Wolffe A.P. Histone deacetylase: a regulator of transcription. Science. 272:1996;371-372.
    • (1996) Science , vol.272 , pp. 371-372
    • Wolffe, A.P.1
  • 95
    • 0032979988 scopus 로고    scopus 로고
    • Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β
    • Wong C., Rougier-Chapman E.M., Frederick J.P., Datto M.B., Liberati N.T., Li J.M., Wang X.F. Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β Mol. Cell. Biol. 19:1999;1821-1830.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1821-1830
    • Wong, C.1    Rougier-Chapman, E.M.2    Frederick, J.P.3    Datto, M.B.4    Liberati, N.T.5    Li, J.M.6    Wang, X.F.7
  • 96
    • 0033515620 scopus 로고    scopus 로고
    • A Smad transcriptional corepressor
    • Wotton D., Lo R.S., Lee S., Massagué J. A Smad transcriptional corepressor. Cell. 97:1999;29-39.
    • (1999) Cell , vol.97 , pp. 29-39
    • Wotton, D.1    Lo, R.S.2    Lee, S.3    Massagué, J.4
  • 100
    • 0033531921 scopus 로고    scopus 로고
    • Positive and negative modulation of vitamin D receptor function by transforming growth factor-β signaling through smad proteins
    • 971-12 974
    • Yanagi Y., Suzawa M., Kawabata M., Miyazono K., Yanagisawa J., Kato S. Positive and negative modulation of vitamin D receptor function by transforming growth factor-β signaling through smad proteins. J. Biol. Chem. 274:1999;12 971-12 974.
    • (1999) J. Biol. Chem. , vol.274 , pp. 12
    • Yanagi, Y.1    Suzawa, M.2    Kawabata, M.3    Miyazono, K.4    Yanagisawa, J.5    Kato, S.6
  • 103
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-β response
    • Zhang Y., Feng X.H., Wu R.Y., Derynck R. Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature. 383:1996;168-172.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.H.2    Wu, R.Y.3    Derynck, R.4
  • 104
    • 0032572723 scopus 로고    scopus 로고
    • Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
    • Zhang Y., Feng X.H., Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature. 394:1998;909-913 Nature. 396:(6710):1998;491. erratum.
    • (1998) Nature , vol.394 , pp. 909-913
    • Zhang, Y.1    Feng, X.H.2    Derynck, R.3
  • 105
    • 0032481046 scopus 로고    scopus 로고
    • erratum
    • Zhang Y., Feng X.H., Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature. 394:1998;909-913 Nature. 396:(6710):1998;491. erratum.
    • (1998) Nature , vol.396 , Issue.6710 , pp. 491
  • 106
    • 0032110707 scopus 로고    scopus 로고
    • Characterization of human FAST-1, a TGFβ and activin signal transducer
    • Zhou S., Zawel L., Lengauer C., Kinzler K.W., Vogelstein B. Characterization of human FAST-1, a TGFβ and activin signal transducer. Mol. Cell. 2:1998;121-127.
    • (1998) Mol. Cell , vol.2 , pp. 121-127
    • Zhou, S.1    Zawel, L.2    Lengauer, C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 107
    • 0033549789 scopus 로고    scopus 로고
    • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    • Zhu H., Kavsak P., Abdollah S., Wrana J.L., Thomsen G.H. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 400:1999;687-693.
    • (1999) Nature , vol.400 , pp. 687-693
    • Zhu, H.1    Kavsak, P.2    Abdollah, S.3    Wrana, J.L.4    Thomsen, G.H.5


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