A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

Genes and Development

Volumn 10, Issue 15, 1996, Pages 1880-1889

  Baker, Julie C ^a   Harland, Richard M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

activin; Madr2; mesoderm; nuclear localization

Indexed keywords

ACTIVIN;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; GENE EXPRESSION; IN SITU HYBRIDIZATION; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0029829230     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.15.1880     Document Type: Article

References (62)

1. Amaya, E., T.J. Musci, and M.W. Kirschner. 1991. Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell 66: 257-270.
2. Beddington, R.S. and E.J. Robertson. 1989. An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. Development 105: 733-737.
3. Bolce, M.E., A. Hemmati-Brivanlou, P.D. Kushner, and R.M. Harland. 1992. Ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin. Development 115: 681-688.
4. Chomczynski, P. and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
5. Condie, B.G. and R.M. Harland. 1987. Posterior expression of a homeobox gene in early Xenopus embryos. Development 101: 93-105.
6. Conlon, F.L., K.S. Barth, and E.J. Robertson. 1991. A novel retrovirally induced embryonic lethal mutation in the mouse: Assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration. Development 111: 969-981.
7. Conlon, F.L., K.M. Lyons, N. Takaesu, K.S. Barth, A. Kispert, B. Herrmann, and E.J. Robertson. 1994. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120: 1919-1928.
8. Cooke, J. 1989. Mesoderm-inducing factors and Spemann's organizer phenomenon in amphibian development. Development 107: 229-241.
9. Deng, C.X., A. Wynshaw-Boris, M.M. Shen, C. Daugherty, D.M. Ornitz, and P. Leder. 1994. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes & Dev. 8: 3045-3057.
10. Faust, C., A. Schumach, B. Holdener, and T. Magnuson. 1995. The eed mutation disrupts anterior mesoderm production in mice. Development 121: 273-285.
11. Feldman, B., W. Poueymirou, V.E. Papaioannou, T.M. DeChiara, and M. Goldfarb. 1995. Requirement of FGF-4 for postimplantation mouse development. Science 267: 246-249.
12. Graff, J.M., R.S. Thies, J.J. Song, A.J. Celeste, and D.A. Melton. 1994. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals overide dorsal signals in vivo. Cell 79: 169-179.
13. Graff, J.M., A. Bansal, and D.A. Melton. 1996. Xenopus mad proteins transduce distinct subsets of signals for the TGFβ superfamily. Cell 85: 479-487.
14. Green, J.B.A. and J.C. Smith. 1990. Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. Nature 347: 391-394.
15. Green, J.B., H.V. New, and J.C. Smith. 1992. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71: 731-739.
16. Hahn, S.A., M. Schutte, A.T. Hoque, C.A. Moskaluk, L.T. da Costa, E. Rozenblum, C.L. Weinstein, A. Fischer, C.J. Yeo, R.H. Hruban, and S.E. Kern. 1996. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353.
17. Harland, R.M. 1994. The transforming growth factor β family and induction of the vertebrate mesoderm: Bone morphogenetic proteins are ventral inducers. Proc. Natl. Acad. Sci. 91: 10243-10246.
18. Hemmati-Brivanlou, A. and D.A. Melton. 1992. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature 359: 609-614.
19. Herrmann, B.G., S. Labeit, A. Poustka, T.R. King, and H. Lehrach. 1990. Cloning of the T gene required in mesoderm formation in the mouse. Nature 343: 617-622.
20. Hogan, B., R. Beddington, F. Costantini, and E. Lacy. 1994. Manipulating the mouse embryo: A laboratory manual (2nd ed.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
21. Holdener, B.C., C. Faust, N.S. Rosenthal, and T. Magnuson. 1994. msd is required for mesoderm induction in mice. Development 120: 1335-1346.
22. Hoodless, P.A., T. Haerry, S. Abdollah, M. Stapleton, M.B. O'Connor, L. Attisano, and J.L. Wrana. 1996. Madrl, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85: 489-500.
23. Johansson, B.M. and M.V. Wiles. 1995. Evidence for involvement of activin A and Bone Morphogenic Protein 4 in mammalian mesoderm and haematopoietic development. Mol. Cell. Biol. 15: 141-151.
24. Jones, C.M., M.R. Kuehn, B.L. Hogan, J.C. Smith, and C.V. Wright. 1995. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development 121: 3651-3662.
25. Karin, M. and T. Hunter. 1995. Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus. Curr. Biol. 5: 747-757.
26. Kessler, D.S. and D.A. Melton. 1994. Vertebrate embryonic induction - mesodermal and neural patterning. Science 266: 596-604.
27. Kingsley, D.M. 1994. The TGF-β superfamily: New members, new receptors, and new genetic tests of fuction in different organisms. Genes & Dev. 8: 133-146.
28. Kintner, C.R. and Brockes, J.P. 1984. Monoclonal antibodies identify blastema cells derived from differentiating muscle in newt limb regeneration. Nature 308: 67-69.
29. Knecht, A.K., P.J. Good, I.E. Dawid, and R.M. Harland. 1995. Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm. Development 121: 1927-1936.
30. Lamb, T.M., A.K. Knecht, W.C. Smith, S.E. Stachel, A.N. Economides, N. Stahl, G.D. Yancopolous, and R.M. Harland. 1993. Neural induction by the secreted polypeptide noggin. Science 262: 713-718.
31. Lemaire, P., N. Garret, and J.B. Gurdon. 1995. Expression cloning of siamois, a Xenopus homeobox gene expressed in dorsal vegetal cells of blastulae and able to induce a complete secondary axis. Cell 81: 85-94.
32. Liu, F., A. Hata, J.C. Baker, J. Doody, J. Carcámo, R.M. Harland, and J. Massagué. 1996. Human Smad1, a mediator of BMP signals, is a transcriptional activator. Nature 38: 620-623.
33. Lyons, K.M., C.M. Jones, and B.L. Hogan. 1991. The DVR gene family in embryonic development. Trends Genet. 7: 408-412.
34. Massagué, J. 1996. TGFβ signaling: Receptors, transducers and Mad proteins. Cell 85: 947-950.
35. Mishina, Y., A. Suzuki, N. Ueno, and R.R. Behringer. 1995. Bmpr encodes a type I bone morphogenic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes & Dev. 9: 3027-3037.
36. Morisato, D. and K.V. Anderson. 1995. Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Annu. Rev. Genetics 29: 371-399.
37. Niehrs, C., R. Keller, K.W. Cho, and E.M. De Robertis. 1993. The homeobox gene goosecoid controls cell migration in Xenopus embryos. Cell 72: 491-503.
38. Roberts, A.B. and M.B. Sporn. 1993. Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 8: 1-9.
39. Robertson, E.J. 1987. Teratocarcinomas and embryonic stem cells: A practical approach. IRL Press, Oxford, UK.
40. Rupp, R.A., L. Snider, and H. Weintraub. 1994. Xenopus embryos regulate the nuclear localization of XMyoD. Genes & Dev. 8: 1311-1323.
41. Sanes, J.R., J.L. Rubenstein, and J.F. Nicolas. 1986. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J. 5: 3133-3142.
42. Sasai, Y., B. Lu, H. Steinbeisser, and E.M. De Robertis. 1995. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature 376: 333-336.
43. Savage, C., P. Das, A.L. Finelli, S.R. Townsend, C.Y. Sun, S.E. Baird, and R.W. Padgett. 1996. Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components. Proc. Natl. Acad. Sci. 93: 790-794.
44. Sekelsky, J.J., S.J. Newfeld, L.A. Raftery, E.H. Chartoff, and W.M. Gelbart. 1995. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139: 1347-1358.
45. Slack, J.M.W. 1994. Inducing factors in Xenopus early embryos. Curr. Bio. 4: 116-126.
46. Smith, W.C. and R.M. Harland. 1991. Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell 67: 753-765.
47. _. 1992. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell 70: 829-840.
48. Smith, W.C., R. McKendry, S. Ribisi, and R.M. Harland. 1995. A nodal-related gene defines a physical and functional domain within the Spemann organizer. Cell 82: 37-46.
49. Sokol, S., J.L. Christian, R.T. Moon, and D.A. Melton. 1991. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell 67: 741-752.
50. Symes, K., C. Yordan, and M. Mercola. 1994. Morphological differences in Xenopus embryonic mesodermal cells are specified as an early response to distinct threshold concentrations of activin. Development 120: 2339-2346.
51. Thomsen, G.H. 1996. Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP 2/4 receptor. Development 122: 2359-2366.
52. Thomsen, G., T. Woolf, M. Whitman, S. Sokol, J. Vaughan, W. Vale, and W. Melton. 1990. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell 63: 485-493.
53. Turner, D.L. and H. Weintraub. 1994. Expression of achaete scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes & Dev. 8: 1434-1447.
54. Vassalli, A., M.M. Matzuk, H.A. Gardner, K.F. Lee, and R. Jaenisch. 1994. Activin/inhibin β B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes & Dev. 8: 414-427.
55. Verma, I.M., K. Stevenson, E.W. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel-NF-κ-B-I-κ-B family: Intimate tales of association and dissociation. Genes & Dev. 9: 2723-2735.
56. Wilkinson, D. 1992. In situ hybridisation: A practical approach. IRL Press, Oxford University, UK.
57. Wilson, P.A. and A. Hemmati-Brivanlou. 1995. Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 376: 331-333.
58. Wilson, P.A. and D.A. Melton. 1994. Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. Biol. 4: 676-86.
59. Winnier, G., M. Blessing, P.A. Labosky, and B.L.M. Hogan. 1995. Bone morphogenic protein-4 is required for mesoderm formation and patterning in the mouse. Genes & Dev. 9: 2105-2116.
60. Wrana, J.L., L. Attisano, R. Wieser, F. Ventura, and J. Massagué. 1994. Mechanism of activation of the TGF-β receptor. Nature 370: 341-347.
61. Yamaguchi, T.P., K. Harpal, M. Henkemeyer, and J. Rossant. 1994. fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes & Dev. 8: 3032-3044.
62. Zhou, X., H. Sasaki, L. Lowe, B.L. Hogan, and M.R. Kuehn. 1993. Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation. Nature 361: 543-547.