메뉴 건너뛰기




Volumn 12, Issue 11, 1998, Pages 1587-1592

Smad2 transduces common signals from receptor serinethreonine and tyrosine kinases

Author keywords

HGF; Protein phosphorylation; Receptor kinases; Signal transduction; SMAD; TGF

Indexed keywords

EPIDERMAL GROWTH FACTOR; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SCATTER FACTOR;

EID: 2642605344     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.11.1587     Document Type: Article
Times cited : (256)

References (38)
  • 1
    • 0030613249 scopus 로고    scopus 로고
    • TβR-I phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
    • Abdollah, S., M. Macias-Silva, T. Tsukazaki, H. Hayashi, L. Attisano, and J.L. Wrana. 1997. TβR-I phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem. 272: 27678-27685.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27678-27685
    • Abdollah, S.1    Macias-Silva, M.2    Tsukazaki, T.3    Hayashi, H.4    Attisano, L.5    Wrana, J.L.6
  • 2
    • 0028328817 scopus 로고
    • An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
    • Abe, M., J.G. Harpel, C.N. Metz, I. Nunes, D.J. Loskutoff, and D.B. Rifkin. 1994. An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal. Biochem. 216: 276-284.
    • (1994) Anal. Biochem. , vol.216 , pp. 276-284
    • Abe, M.1    Harpel, J.G.2    Metz, C.N.3    Nunes, I.4    Loskutoff, D.J.5    Rifkin, D.B.6
  • 5
    • 15844393132 scopus 로고    scopus 로고
    • Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity
    • Cioce, V., K.G. Csaky, A.M.L. Chan, D.P. Bottaro, W.G. Taylor, R. Jensen, S.A. Aaronson, and J.S. Rubin. 1996. Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity. J. Biol. Chem. 271: 13110-13115.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13110-13115
    • Cioce, V.1    Csaky, K.G.2    Chan, A.M.L.3    Bottaro, D.P.4    Taylor, W.G.5    Jensen, R.6    Aaronson, S.A.7    Rubin, J.S.8
  • 6
    • 0030934472 scopus 로고    scopus 로고
    • The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways
    • Coolican, S.A., D.S. Samuel, D.Z. Ewton, F.J. McWade, and J.R. Florini. 1997. The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways. J. Biol. Chem. 272: 6653-6662.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6653-6662
    • Coolican, S.A.1    Samuel, D.S.2    Ewton, D.Z.3    McWade, F.J.4    Florini, J.R.5
  • 8
    • 0030963943 scopus 로고    scopus 로고
    • DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells
    • de Winter, J.P., B.A. Roelen, P. ten Dijke, B. van der Burg, and A.J. van den Eijnden-van Raaij. 1997. DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells. Oncogene 14: 1891-1899.
    • (1997) Oncogene , vol.14 , pp. 1891-1899
    • De Winter, J.P.1    Roelen, B.A.2    Ten Dijke, P.3    Van Der Burg, B.4    Van Den Eijnden-van Raaij, A.J.5
  • 9
    • 0027952883 scopus 로고
    • Induction of chondrogenesis: Requirement for synergistic interaction of basic fibroblast growth factor and transforming growth factor-β
    • Frenz, D.A., W. Liu, J.D. Williams, V. Hatcher, V. Galinovic-Schwartz, K.C. Flanders, and T.R. Van de Water. 1994. Induction of chondrogenesis: Requirement for synergistic interaction of basic fibroblast growth factor and transforming growth factor-β. Development 120: 415-424.
    • (1994) Development , vol.120 , pp. 415-424
    • Frenz, D.A.1    Liu, W.2    Williams, J.D.3    Hatcher, V.4    Galinovic-Schwartz, V.5    Flanders, K.C.6    Van De Water, T.R.7
  • 10
  • 12
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin, C.H., K. Miyazono, and P. ten Dijke. 1997. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 13
    • 0023864574 scopus 로고
    • Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-β. Divergent responses in lung fibroblasts and carcinoma cells
    • Keski-Oja, J., R. Raghow, M. Sawdey, D.J. Loskutoff, A.E. Postlethwaite, A.H. Kang, and H.L. Moses. 1988. Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-β. Divergent responses in lung fibroblasts and carcinoma cells. J. Biol. Chem. 263: 3111-3115.
    • (1988) J. Biol. Chem. , vol.263 , pp. 3111-3115
    • Keski-Oja, J.1    Raghow, R.2    Sawdey, M.3    Loskutoff, D.J.4    Postlethwaite, A.E.5    Kang, A.H.6    Moses, H.L.7
  • 14
    • 0030872367 scopus 로고    scopus 로고
    • Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    • Kim, J., K. Johnson, H.J. Chen, S. Carroll, and A. Laughon. 1997. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388: 304-308.
    • (1997) Nature , vol.388 , pp. 304-308
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 15
    • 0030773834 scopus 로고    scopus 로고
    • Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
    • Kretzschmar, M., J. Doody, and J. Massagué. 1997a. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1. Nature 389: 618-622.
    • (1997) Nature , vol.389 , pp. 618-622
    • Kretzschmar, M.1    Doody, J.2    Massagué, J.3
  • 16
    • 0030911104 scopus 로고    scopus 로고
    • The TGF-β family mediator Smadl is phosphorylated directly and activated functionally by the BMP receptor kinase
    • Kretzschmar, M., F. Liu, A. Hata, J. Doody, and J. Massagué. 1997b. The TGF-β family mediator Smadl is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes & Dev. 11: 984-995.
    • (1997) Genes & Dev. , vol.11 , pp. 984-995
    • Kretzschmar, M.1    Liu, F.2    Hata, A.3    Doody, J.4    Massagué, J.5
  • 17
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
    • Lagna, G., A. Hata, A. Hemmati-Brivanlou, and J. Massagué. 1996. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383: 832-836.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massagué, J.4
  • 18
    • 0025129867 scopus 로고
    • Concomitant loss of transforming growth factor (TGF)-β receptor types I and II in TGF-β-resistant cell mutants implicates both receptor types in signal transduction
    • Laiho, M., M.B. Weis, and J. Massagué. 1990. Concomitant loss of transforming growth factor (TGF)-β receptor types I and II in TGF-β-resistant cell mutants implicates both receptor types in signal transduction. J. Biol. Chem. 265: 18518-18524.
    • (1990) J. Biol. Chem. , vol.265 , pp. 18518-18524
    • Laiho, M.1    Weis, M.B.2    Massagué, J.3
  • 19
    • 0030013242 scopus 로고    scopus 로고
    • Serine phosphorylation, chromosomal localization, and transforming growth factor-β signal transduction by human bsp-1
    • Lechleider, R.J., M.P. de Caestecker, A. Dehejia, M.H. Polymeropoulos, and A.B. Roberts. 1996. Serine phosphorylation, chromosomal localization, and transforming growth factor-β signal transduction by human bsp-1. J. Biol. Chem. 271: 17617-17620.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17617-17620
    • Lechleider, R.J.1    De Caestecker, M.P.2    Dehejia, A.3    Polymeropoulos, M.H.4    Roberts, A.B.5
  • 21
    • 0030690337 scopus 로고    scopus 로고
    • Dual role of the Smad4/ DPC4 tumor suppressor in TGF-β-inducible transcriptional complexes
    • Liu, F., C. Pouponnot, and J. Massagué. 1997. Dual role of the Smad4/ DPC4 tumor suppressor in TGF-β-inducible transcriptional complexes. Genes & Dev. 11: 3157-3167.
    • (1997) Genes & Dev. , vol.11 , pp. 3157-3167
    • Liu, F.1    Pouponnot, C.2    Massagué, J.3
  • 22
    • 0030601359 scopus 로고    scopus 로고
    • Combined BMP-2 and FGF-4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm
    • Lough, J., M. Barron, M. Brogley, Y. Sugi, D.L. Bolender, and X. Zhu. 1996. Combined BMP-2 and FGF-4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm. Dev. Biol. 178: 198-202.
    • (1996) Dev. Biol. , vol.178 , pp. 198-202
    • Lough, J.1    Barron, M.2    Brogley, M.3    Sugi, Y.4    Bolender, D.L.5    Zhu, X.6
  • 23
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling
    • Macias-Silva, M., S. Abdollah, P.A. Hoodless, R. Pirone, L. Attisano, and J.L. Wrana. 1996. MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87: 1215-1224.
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macias-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 24
    • 0030604542 scopus 로고    scopus 로고
    • TGFβ signaling: Receptors, transducers, and Mad proteins
    • Massagué, J. 1996. TGFβ signaling: Receptors, transducers, and Mad proteins. Cell 85: 947-950.
    • (1996) Cell , vol.85 , pp. 947-950
    • Massagué, J.1
  • 25
    • 0031034589 scopus 로고    scopus 로고
    • Identification of Smad2, a human Mad-related protein in the transforming growth factor β signaling pathway
    • Nakao, A., E. Roijer, T. Imamura, S. Souchelnytskyi, G. Stenman, C.H. Heldin, and P. ten Dijke. 1997. Identification of Smad2, a human Mad-related protein in the transforming growth factor β signaling pathway. J. Biol. Chem. 272: 2896-2900.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2896-2900
    • Nakao, A.1    Roijer, E.2    Imamura, T.3    Souchelnytskyi, S.4    Stenman, G.5    Heldin, C.H.6    Ten Dijke, P.7
  • 26
    • 0027452636 scopus 로고
    • FGF-4 and BMP-2 have opposite effects on limb growth
    • Niswander, L. and G.R. Martin. 1993. FGF-4 and BMP-2 have opposite effects on limb growth. Nature 361: 68-71.
    • (1993) Nature , vol.361 , pp. 68-71
    • Niswander, L.1    Martin, G.R.2
  • 27
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • Pawson, T. 1995. Protein modules and signalling networks. Nature 373: 573-580.
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 28
    • 0029760745 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells
    • Rahimi, N., E. Tremblay, and B. Elliott. 1996. Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells. J. Biol. Chem. 271: 24850-24855.
    • (1996) J. Biol. Chem. , vol.271 , pp. 24850-24855
    • Rahimi, N.1    Tremblay, E.2    Elliott, B.3
  • 29
    • 0020508917 scopus 로고
    • Transforming growth factors from neoplastic and nonneoplastic tissues
    • Roberts, A.B., C.A. Frolik, M.A. Anzano, and M.B. Sporn. 1983. Transforming growth factors from neoplastic and nonneoplastic tissues. Fed. Proc. 42: 2621-2626.
    • (1983) Fed. Proc. , vol.42 , pp. 2621-2626
    • Roberts, A.B.1    Frolik, C.A.2    Anzano, M.A.3    Sporn, M.B.4
  • 30
    • 0030613262 scopus 로고    scopus 로고
    • Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling
    • Souchelnytskyi, S., K. Tamaki, U. Engstrom, C. Wernstedt, P. ten Dijke, and C.H. Heldin. 1997. Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling. J. Biol. Chem. 272: 28107-28115.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28107-28115
    • Souchelnytskyi, S.1    Tamaki, K.2    Engstrom, U.3    Wernstedt, C.4    Ten Dijke, P.5    Heldin, C.H.6
  • 31
    • 0030862345 scopus 로고    scopus 로고
    • Synergistic interactions between bFGF and a TGF-β family member may mediate myogenic signals from the neural tube
    • Stern, H.M., J. Lin-Jones, and S.D. Hauschka. 1997. Synergistic interactions between bFGF and a TGF-β family member may mediate myogenic signals from the neural tube. Development 124: 3511-3523.
    • (1997) Development , vol.124 , pp. 3511-3523
    • Stern, H.M.1    Lin-Jones, J.2    Hauschka, S.D.3
  • 32
    • 0031013613 scopus 로고    scopus 로고
    • Synergistic enhancement of EGF, but not HGF, stimulated hepatocyte motility by TGF-β 1 in vitro
    • Stolz, D.B. and G.K. Michalopoulos. 1997. Synergistic enhancement of EGF, but not HGF, stimulated hepatocyte motility by TGF-β 1 in vitro. J. Cell Physiol. 170: 57-68.
    • (1997) J. Cell Physiol. , vol.170 , pp. 57-68
    • Stolz, D.B.1    Michalopoulos, G.K.2
  • 33
    • 0026486878 scopus 로고
    • Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
    • Traverse, S., N. Gomez, H. Paterson, C. Marshall, and P. Cohen. 1992. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288: 351-355.
    • (1992) Biochem. J. , vol.288 , pp. 351-355
    • Traverse, S.1    Gomez, N.2    Paterson, H.3    Marshall, C.4    Cohen, P.5
  • 34
    • 0028337426 scopus 로고
    • Hepatocyte growth factor stimulates expression of plasminogen activator inhibitor type 1 and tissue factor in HepG2 cells
    • Wojta, J., T. Nakamura, A. Fabry, P. Hufnagl, R. Beckmann, K. McGrath, and B.R. Binder. 1994. Hepatocyte growth factor stimulates expression of plasminogen activator inhibitor type 1 and tissue factor in HepG2 cells. Blood 84: 151-157.
    • (1994) Blood , vol.84 , pp. 151-157
    • Wojta, J.1    Nakamura, T.2    Fabry, A.3    Hufnagl, P.4    Beckmann, R.5    McGrath, K.6    Binder, B.R.7
  • 36
    • 0028361791 scopus 로고
    • Two different signal transduction pathways can be activated by transforming growth factor β 1 in epithelial cells
    • Yan, Z., S. Winawer, and E. Friedman. 1994. Two different signal transduction pathways can be activated by transforming growth factor β 1 in epithelial cells. J. Biol. Chem. 269: 13231-13237.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13231-13237
    • Yan, Z.1    Winawer, S.2    Friedman, E.3
  • 37
    • 0030697971 scopus 로고    scopus 로고
    • Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein
    • Yingling, J.M., M.B. Datto, C. Wong, J.P. Frederick, N.T. Liberati, and X.F. Wang. 1997. Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. Mol. Cell Biol. 17: 7019-7028.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 7019-7028
    • Yingling, J.M.1    Datto, M.B.2    Wong, C.3    Frederick, J.P.4    Liberati, N.T.5    Wang, X.F.6
  • 38
    • 0031128153 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function
    • Zhang, Y., T. Musci, and R. Derynck. 1997. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Curr. Biol. 7: 270-276.
    • (1997) Curr. Biol. , vol.7 , pp. 270-276
    • Zhang, Y.1    Musci, T.2    Derynck, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.