The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx

Development

Volumn 126, Issue 1, 1999, Pages 97-107

  Thatcher, Jack D ^a   Haun, Christina ^a   Okkema, Peter G ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Caenorhabditis elegans; DAF 3; Dauer; DNA binding; Pharynx; Smad; TGF

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; DNA BINDING; DNA SEQUENCE; EMBRYO; EMBRYO DEVELOPMENT; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; LARVAL DEVELOPMENT; NONHUMAN; PHARYNX; PRIORITY JOURNAL; SKELETAL MUSCLE;

ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CONSERVED SEQUENCE; DNA; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION, DEVELOPMENTAL; HELMINTH PROTEINS; MUTATION; PHARYNX; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REGULATORY SEQUENCES, NUCLEIC ACID; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; CAENORHABDITIS ELEGANS; INVERTEBRATA; VERTEBRATA;

EID: 0032957753     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. and Struhl, K., ed. (1990). Current Protocols in Molecular Biology. New York: John Wiley and Sons.
2. Azzaria, M., Goszczynski, B., Chung, M. A., Kalb, J. M. and McGhee J. D. (1996). A fork head/HNF-3 homolog expressed in the pharynx and intestine of the Caenorhabditis elegans embryo. Dev. Biol. 178, 289-303.
3. Cassada, R. C. and Russel, R. L. (1975). The dauer larva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans. Dev. Biol. 46, 326-342.
4. Chen, X., Rubock, M. J. and Whitman, M. (1996). A transcriptional partner for MAD proteins in TGF-β signalling. Nature 383, 691-696.
5. Chen, X., Weisberg, K., Fridmacher, V., Watanabe, M., Naco, G. and Whitman, M. (1997). Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389, 85-89.
6. Christianson, T., Sikorski, R., Dante, M., Shero, J. and Hieter, P. (1992). Multifunctional yeast high copy number shuttle vectors. Gene 110, 119-122.
7. Costa, R. H. (1994). Hepalocyte nuclear factor 3/Forkhead protein family mammalian transcription factors that possess divergent cellular expression patterns and binding specificities. In Liver gene expression. (ed F. Tronche and M. Yaniv). R.G. Landes Company.
8. Durfee, T., Becherer, K., Chen, P-L., Yeh, S-H., Yang, Y., Kilburn, A. E., Lee, W-H. and Elledge, S. J. (1993). The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569.
9. Estevez, M., Attisano, L., Wrana, J. L., Albert, P. S., Massagué, J. and Riddle, D. L. (1993). The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature 365, 644-649.
10. Gietz, R. D., Schiestl, R. H., Willems, A. R. and Woods, R. A. (1995). Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast 11, 355-360.
11. Georgi, L. L., Albert, P. S. and Riddle, D. L. (1990). daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Cell 18, 635-645.
12. Golden, J. W. and Riddle, D. L. (1982). A pheromone influences larval development in the nematode Caenorhabditis elegans. Science 218, 578-580.
13. Grenache, D. G., Caldicott, I., Albert, P. S., Riddle, D. L. and Politz, S. M. (1996). Environmental induction and genetic control of surface antigen switching in the nematode Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 93, 12388-12393.
14. Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H. and Kern, S. E. (1996). DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350-353.
15. Harwood, C. R. and Cutting, S. M. (1990). Molecular Biological Methods for bacillus, pp 548. West Sussex, England: John Wiley and Sons Ltd.
16. Hata, A., Lagna, G., Massagué, J. and Hemmati-Brivanlou, A. (1998). Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 12, 186-197.
17. Haun, C., Alexander, J., Stainier, D. and Okkema, P. G. (1998). Rescue of C. elegans pharyngeal development by a vertebrate heart specification gene. Proc. Natl. Acad. Sci. USA 95, 5072-5075.
18. Heldin, C. H., Miyazono, K. and ten Dijke, P. (1997). TGF-β signalling from cell membrane to the nucleus through SMAD proteins. Nature 390, 465-471.
19. Horner, M., Quintin, S., Domeier, M. E., Kimble, J., Labouesse, M. and Mango, S. E. (1998). pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in C. elegans. Genes Dev. 12, 1947-1952.
20. Imamura, T., Masao, T., Nishihara, A., Oeda, E., Hanai, J., Kawabata, M. and Miyazono, K. (1997). Smad6 inhibits signalling by the TGF-β superfamily. Nature 389, 622-626.
21. Johnson, A. D. (1995). The price of repression. Cell 81, 655-658.
22. Kalb, J. M., Lau, K. K., Goszczynski, B., Fukushige, T., Moons, D., Okkema, P. G. and McGhee J. D. (1998). pha-4 is Ce-fkh-1, a fork head/HNF-3α,β,γ homolog that functions in organogenesis of the C. elegans pharynx. Development 125, 2171-2180.
23. Kaufmann, E., Muller, D. and Knochel, W. (1995). DNA recognition site analysis of Xenopus winged helix proteins. J. Mol. Biol. 248, 239-254.
24. Kim, J., Johnson, K., Chen, H. J., Carroll, S. and Laughon, A. (1997). Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304-308.
25. Kingsley, D. M. (1994). The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8, 133-146.
26. Kretzschmar, M., Liu, F., Hata, A., Doody, J. and Massagué, J. (1997). The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11, 984-995.
27. Lagna, G., Hata, A., Hemmati-Brivanlou, A. and Massagué, J. (1996). Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383, 832-836.
28. Liu, F., Pouponnot, C. and Massagué, J. (1997). Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes Dev. 11, 3157-3167.
29. Mango, S. E., Lambie, E. J. and Kimble J. (1994). The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans. Development 120, 3019-3031.
30. Massagué, J., Hata, A. and Liu, F. (1997). TGF-β signalling through the Smad pathway. Trends Cell Biol. 7, 187-192.
31. Mello, C. and Fire, A. (1995). DNA transformation. In Methods in Cell Biology. Vol 48. Caenorhabditis elegans: ModernBiological Analysis of an Organism. (ed. H. F. Epstein and D. C. Shakes), pp 451-482. San Diego, CA: Academic Press, Inc.
32. Nakao, A., Afrakhte, M., Moren, A., Nakayama, T., Christian, J. L., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N. F., Heldin, C. H. and ten Dijke, P. (1997). Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389, 631-635.
33. Okkema, P. G., Harrison, S. W., Plunger, V., Aryana, A. and Fire, A. (1993). Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans. Genetics 135, 385-404.
34. Okkema, P. G. and Fire, A. (1994). The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle. Development 120, 2175-2186.
35. Padgett, R. W., Savage, C. and Das, P. (1997). Genetic and biochemical analysis of TGFβ signal transduction. Cytokine Growth Factor Rev. 8, 1-9.
36. Patterson, G. I., Koweek, A., Wong, A., Liu, Y. and Ruvkun, G. (1997). The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 11, 2679-2690.
37. Pierrou, S., Hellqvist, M., Samuelsson, L., Enerback, S. and Carlsson, P. (1994). Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 13, 5002-5012.
38. Raftery, L. A., Twombly, V., Wharton, K. and Gelbart, W. M. (1995). Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139, 241-254.
39. Ren, P., Lim, C. S., Johnsen, R., Albert, P. S., Pilgrim, D. and Riddle, D. L. (1996). Control of C. elegans larval development by neuronal expression of a TGF-β homolog. Science 274, 1389-1391.
40. Riddle, D. L. (1977). A genetic pathway for dauer larva formation in Caenorhabditis elegans. Stadle Genet. Symp. 9, 101-120.
41. Riddle, D. L. and Albert, P. S. (1997). Genetic and Environmental Regulation of Dauer Larva Development. In C. Elegans II. (ed. D. L. Riddle, T. Blumenthal, B. J. Meyer, and J. R. Priess), pp 739-768. Cold Spring Harbor NY: Cold Spring Harbor Laboratory Press.
42. Riddle, D. L., Swanson, M. M. and Albert, P. S. (1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-671.
43. Savage, C., Das, P., Finelli, A. L., Townsend, S. R., Sun, C. Y., Baird, S. E. and Padgett, R. W. (1996). Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor (pathway components. Proc. Natl. Acad. Sci. USA 93, 790-794.
44. Sekelsky, J. J., Newfeld, S. J., Raftery, L. A., Chartoff, E. H. and Gelbart, W. M. (1995). Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139, 1347-1358.
45. Sikorski, R. S. and Hieter P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisae. Genetics 122, 19-27.
46. Smith, D.B. (1993). Purification of glutathione-S-transferase fusion proteins. Methods Mol. Cell Biol. 4, 220-229.
47. Sulston, J. E. and Hodgkin, J. (1988). Methods. In TheNematode Caenorhabditis elegans. (ed. W.B. Wood), pp 587-606. Cold Spring Harbor NY: Cold Spring Harbor Laboratory Press.
48. Thatcher, J. D., MacBride, B. and Katula, K. S. (1995). Promoter binding factors regulating cyclin B transcription in the sea urchin embryo. DNA Cell Biol. 14, 869-881.
49. Thomas, J. H., Birnby, D. A. and Vowels, J. J. (1993). Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans. Genetics 134, 1105-1117.
50. Tsuneizumi, K., Nakayama, T., Kamoshida, Y., Kornberg, T. B., Christian, J. L. and Tabata, T. (1997). Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature 389, 627-631.
51. Vowels, J. J. and Thomas, J. H. (1992). Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130, 105-123.
52. Wang, M. M. and Reed, R. R. (1993). Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast. Nature 364, 121-126.
53. Wilson, T. E., Fahrner, T. J., Johnston, M. and Milbrandt, J. (1991). Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252, 1296-1300.
54. Wisotzkey, R. G., Mehra, A., Sutherland, D. J., Dobens, L. L, Liu, X., Dohrmann, C., Attisano, L. and Raftery, L. (1998). Medea is a Drosphila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125, 1433-1445.
55. Wu, R. Y., Zhang, Y., Feng, X. H. and Derynck R. (1997). Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17, 2521-2528.
56. Xu, X., Yin, Z., Hudson, J. B., Ferguson, E. L. and Frasch, M. (1998). Smad proteins act in combination with synergistic and antogonistic regulators to target Dpp responses to the Drosophila mesoder. Genes Dev. 12, 2354-2370.
57. Yingling, J. M., Datto, M. B., Wong, C., Frederick, J. P., Liberati, N. T. and Wang, X. F. (1997). Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein. Mol. Cell. Biol. 17, 7019-7028.
58. Zawel, L., Dai, J. L., Buckhaults, P., Zhou, S., Kinzler, K. W., Vogelstein, B. and Kern, S. E. (1998). Human Smad3 and Smad4 are sequence-specific transcription activators. Molecular Cell 1, 611-617.