Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye

Development

Volumn 122, Issue 7, 1996, Pages 2153-2162

  Wiersdorff, Volker ^a   Lecuit, Thomas ^a   Cohen, Stephen M ^a   Mlodzik, Marek ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Decapentaplegic (Dpp); Drosophila; Eye; Mad; Pattern formation; wingless

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL TISSUE; ARTICLE; DEVELOPMENTAL GENETICS; DROSOPHILA; EMBRYO; EMBRYO PATTERN FORMATION; EYE DEVELOPMENT; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALLELES; ANIMALS; CLONING, MOLECULAR; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EYE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSECT HORMONES; INTRONS; MICROSCOPY, ELECTRON, SCANNING; MORPHOGENESIS; POINT MUTATION; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; WING;

ANIMALIA;

EID: 0030037438     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Arora, K., Dai, H., Kazuko, S. G., Jamal, J., O'Connor, M. B., Letsou, A. and Warrior, R. (1995) The Drosophila schnurri gene acts in the Dpp/TGF-β signaling pathway and encodes a transcription factor homologous to the human MBP family. Cell 81, 781-790.
2. Attisano, L., Wrana, J. L., Lopez-Casillas, F. and Massagué, J. (1994) TGF-β receptors and actions. Biochim. Biophys. Acta 1222, 71-80.
3. Blackman, R. K., Sanicola, M., Raftery, L. A., Gillevet, T. and Gelbart, W. M. (1991) An extensive 3′ cis-regulatory region directs the imaginal disc expression of decapentaplegic, a member of the TGF-β family in Drosophila. Development 111, 657-666.
4. Capdevila, J. and Guerrero, I. (1994) Targeted expression of the signalling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J. 13, 4459-4468.
5. Chanut, F. and Heberlein, U. (1995) Role of the morphogenetic furrow in establishing polarity in the Drosophila eye. Development 121, 4085-4094.
6. Diaz-Benjumea, F. J., Cohen, B. and Cohen, S. M. (1994) Cell interaction between compartments establishes the proximal-distal axis of Drosophila limbs. Nature 372, 175-179.
7. Ellis, M. C., Weber, U., Wiersdorff, V. and Mlodzik, M. (1994) Confrontation of scabrous expressing and non-expressing cells is essential for normal ommatidial spacing in the Drosophila eye. Development 120, 1959-1969.
8. Ferguson, E. L. and Anderson, K. V. (1992) decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71, 451-461.
9. Grieder, N. C., Nellen, D., Burke, R., Basler, K. and Affolter, M. (1995) schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. Cell 81, 791-800.
10. Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H. and Kern, S. E. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350-353.
11. Hay, B., Wolff, T. and Rubin, G. M. (1994) Expression of baculovirus P35 prevents cell death in Drosophila. Development 120, 2121-2129.
12. Heberlein, U. and Moses, K. (1995) Mechanisms of Drosophila retinal morphogenesis: the virtues of being progressive. Cell 81, 987-990.
13. Heberlein, U., Singh, C. M., Luk, A. Y. and Donohue, T. J. (1995) Growth and differentiation in the Drosophila eye coordinated by hedgehog. Nature 373, 709-711.
14. Heberlein, U., Wolff, T. and Rubin, G. M. (1993) The TGFβ homolog dpp and the segment polarity gene hedgehog are required for the propagation of a morphogenetic wave in the Drosophila retina. Cell 75, 913-926.
15. Jiang, J. and Struhl, G. (1995) Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80, 563-572.
16. Lepage, T., Cohen, S. M., Diaz-Benjumea, F. J. and Parkhurst, S. M. (1995) Signal transduction by cAMP-dependent protein kinase A in Drosophila limb pattern. Nature 373, 711-715.
17. Letsou, A., Arora, K., Wrana, J. L., Simin, K., Twombly, V., Jamal, J., Staeheling-Hampton, K., Hofmann, F. M., Gelbart, W. M., Massagué, J. and O'Connor, M. B. (1995) Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF-β receptor family. Cell 80, 899-908.
18. Li, W., Ohlmeyer, J. T., Lane, M. E. and Kalderon, D. (1995) Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-562.
19. Ma, C. and Moses, K. (1995) wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye. Development 121, 2279-2289.
20. Ma, C., Zhou, Y., Beachy, P. A. and Moses, K. (1993) The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75, 927-938.
21. Mardon, G., Solomon, N. M. and Rubin, G. M. (1994) dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Development 120, 3473-3486.
22. Massagué, J. (1992) Receptors for the TGF-β family. Cell 69, 1067-1070.
23. Masucci, J. D., Miltenberger, R. J. and Hoffmann, F. M. (1990) Pattern-specific expression of the Drosophila decapentaplegic gene in imaginal discs is regulated by 3′ cis-regulatory elements. Genes Dev 4, 2011-2023.
24. Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C. S. and Rubin, G. M. (1990) The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell 60, 211-224.
25. Nellen, D., Affolter, M. and Basler, K. (1994) Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell 78, 225-237.
26. Newfeld, S. J., Chartoff, E. H., Graff, J. M., Melton, D. A. and Gelbart, W. M. (1996). Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells. Development 122, 2099-2108.
27. Padgett, R. W., Wozney, J. M. and Gelbart, W. M. (1993) Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 90, 2905-2909.
28. Pan, D. and Rubin, G. M. (1995) cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543-552.
29. Raftery, L. A., Twombly, V., Wharton, K. and Gelbart, W. M. (1995) Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139, 241-254.
30. Ready, D. F. (1989) A multifaceted approach to neural development. Trends Neurosci. 12, 102-110.
31. Ruberte, E., Marty, T., Nellen, D., Affolter, M. and Basler, K. (1995) An absolute requirement for both the type II and type I receptors, punt and thickveins, for Dpp signaling in vivo. Cell 80, 889-897.
32. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989). Molecular Cloning. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
33. Sampath, T. K., Rashka, K. E., Doctor, J. S., Tucker, R. F. and Hoffmann, F. M. (1993) Drosophila TGF-β superfamily proteins induce endochondrial bone formation in mammals. Proc. Natl. Acad. Sci. USA 90, 6004-6008.
34. Savage, C., Das, P., Finelli, A. L., Townsend, S. R., Sun, C.-V., Baird, S. E. and Padgett, R. W. (1996) C. elegans genes sma-2. sma-3, and sma-4 define a conserved family of transforming growth factor β pathway components. Proc. Natl. Acad. Sci. USA 93, 790-794.
35. Sekelsky, J. J., Newfeld, S. J., Raftery, L. A., Chartoff, E. H. and Gelbart, W. M. (1995) Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139, 1347-1358.
36. Spradling, A. C. and Rubin, G. M. (1982) Transposition of cloned P-elements into Drosophila germ line chromosomes. Science 218, 341-347.
37. Strutt, D. I. and Mlodzik, M. (1995) Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions. Development 121, 4247-4256.
38. Strutt, D. I., Wiersdorff, V. and Mlodzik, M. (1995) Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature 373, 705-709.
39. Tomlinson, A. (1988) Cellular interactions in the developing Drosophila eye. Development 104, 183-193.
40. Tomlinson, A. and Ready, D. F. (1987) Cell fate in the Drosophila Ommatidium. Der. Biol. 123, 264-275.
41. Török, T., Tick, G., Alvarado, M. and Kiss, I. (1993) P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes. Genetics 135, 71-80.
42. Treisman, J. E., Lai, Z.-C. and Rubin, G. M. (1995) shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-β responsive gene. Development 121, 2835-2845.
43. Treisman, J. E. and Rubin, G. M. (1995) wingless inhibits morphogenetic furrow movement in the Drosophila eye disc. Development 121, 3519-3527.
44. Vincent, J.-P., Girdham, C. H. and O'Farrell, P. H. (1994) A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev. Biol. 164, 328-331.
45. Wall, N. A. and Hogan, B. L. M. (1994) TGFβ related genes in development. Curr. Opin. Genet. Dev. 4, 517-522.
46. Wehrli, M. and Tomlinson, A. (1995) Epithelial planar polarity in the developing Drosophila eye. Development 121, 2451-2459.
47. Wharton, K. A., Ray, R. P. and Gelbart, W. M. (1993) An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo. Development 117, 807-822.
48. Wieser, R., Wrana, J. and Massagué, J. (1995) GS domain mutants that constitutively activate TβR-1, the downstream signaling component in the TGF-b receptor complex. EMBO J. 14, 2199-2208.
49. Wrana, J. L., Attisano, L., Wieser, R., Ventura, F. and Massagué, J. (1994) Mechanism of activation of the TGF-β receptor. Nature 370, 341-347.
50. Xu, T. and Rubin, G. M. (1993) Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.
51. Zecca, M., Basler, K. and Struhl, G. (1995) Sequential organising activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265-2278.