Characterization of human FAST-1, a TGFβ and activin signal transducer

Molecular Cell

Volumn 2, Issue 1, 1998, Pages 121-127

  Zhou, Shibin ^a   Zawel, Leigh ^a   Lengauer, Christoph ^a   Kinzler, Kenneth W ^a   Vogelstein, Bert ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; DNA; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXH1 PROTEIN, HUMAN; FOXH1 PROTEIN, MOUSE; INHIBIN; SMAD2 PROTEIN; SMAD2 PROTEIN, HUMAN; SMAD2 PROTEIN, MOUSE; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN; SMAD4 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; XENOPUS PROTEIN; XSMAD4A PROTEIN, XENOPUS; XSMAD4B PROTEIN, XENOPUS;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CONSENSUS SEQUENCE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MACROMOLECULE; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; NUDE MOUSE; PHYSIOLOGY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ACTIVINS; AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; CONSENSUS SEQUENCE; DNA; DNA, NEOPLASM; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMANS; INHIBINS; MACROMOLECULAR SUBSTANCES; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; XENOPUS PROTEINS;

EID: 0032110707     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80120-3     Document Type: Article

References (36)

1. Attisano, L., Wrana, J.L., Montalvo, E., and Massague, J. (1996). Activation of signaling by the activin receptor complex. Mol. Cell. Biol. 16, 1066-1073.
2. Chen, X., Rubock, M.J., and Whitman, M. (1996). A transcriptional partner for MAD proteins in TGF-β signaling. Nature 383, 691-696.
3. Chen, X.,Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G., and Whitman, M. (1997). Smad4 and FAST-1 in the assembly of activinresponsive factor. Nature 389, 85-89.
4. Clark, K.L., Malay, E.D., Lai, E., and Burley, S.K. (1993). Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364, 412-420.
5. Derynck, R., and Feng, X.H. (1997). TGF-β receptor signaling. Biochim. Biophys. Acta. 1333, F105-F150.
6. Dunham, I., Lengauer, C., Cremer, T., and Featherstone, T. (1992). Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction. Hum. Genet. 88, 457-462.
7. Fynan, T.M., and Reiss, M. (1993). Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis. Crit. Rev. Oncog. 4, 493-540.
8. Hartsough, M.T., and Mulder, K.M. (1997). Transforming growth factor-β signaling in epithelial cells. Pharmacol. Ther. 75, 21-41.
9. Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y.Y., Grinnell, B.W., Richardson, M.A., Topper, J.N., Gimbrone, M.A., Jr., Wrana, J.L., et al. (1997). The MAD-related protein Smad7 associates with the TGF-β receptor and functions as an antagonist of TGF-β signaling. Cell 89, 1165-1173.
10. Heldin, C.H., Miyazono, K., and ten Dijke, P. (1997). TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.
11. Hoodless, P.A., and Wrana, J.L. (1998). Mechanism and function of signaling by the TGF-β superfamily. Curr. Top. Microbiol. Immunol. 228, 235-272.
12. Kaufmann, E., and Knochel, W. (1996). Five years on the wings of fork head. Mech. Dev. 57, 3-20.
13. Kim, J., Johnson, K., Chen, H.J., Carroll, S., and Laughon, A. (1997). Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304-308.
14. Kozak, M. (1992). Regulation of translation in eukaryotic systems. Annu. Rev. Cell Biol. 8, 197-225.
15. Kretzschmar, M., Liu, F., Hata, A., Doody, J., and Massague, J. (1997). The TGF-β family mediator Smadl is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11, 984-995.
16. Kretzschmar, M., and Massague, J. (1998). SMADs: mediators and regulators of TGF-β signaling. Curr. Opin. Genet. Dev. 8, 103-111.
17. Lagna, G., Hata, A., Hemmati-Brivanlou, A., and Massague, J. (1996). Partnership between DPC4 and SMAD proteins in TGF-β signaling pathways. Nature 383, 832-836.
18. Lengauer, C., Kinzler, K.W., and Vogelstein, B. (1997). Genetic instability in colorectal cancers. Nature 386, 623-627.
19. Lichter, P., Tang, C.J., Call, K., Hermanson, G., Evans, G.A., Housman, D., and Ward, D.C. (1990). High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science 247, 64-69.
20. Liu, F., Hata A., Baker, J.C., Doody, J., Carcamo, J., Harland, R.M., and Massague, J. (1996). A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620-623.
21. Liu, F., Pouponnot, C., and Massague, J. (1997). Dual role of the Smad4/DPC4 tumor suppressor in TGF-β-inducible transcriptional complexes. Genes Dev. 11, 3157-3167.
22. Macias-Silva, M., Abdollah, S., Hoodless, P.A., Pirone, R., Attisano, L., and Wrana, J.L. (1996). M ADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215-1224.
23. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R.S., Zborowska, E., Kinzler, K.W., Vogelstein, B., et al. (1995). Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268, 1336-1338.
24. Nakao, A., imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki, K., Hanai, J., Heldin, C.H., Miyazono, K., et al. (1997a). TGF-β receptor-mediated signaling through Smad2, Smad3 and Smad4. EMBO J. 16, 5353-5362.
25. Nakao, A., Roijer, E., Imamura, T., Souchelnytskyi, S., Stenman, G., Heldin, C.H., 61nd ten Dijke, P. (1997b). Identification of Smad2, a human Mad-related protein in the transforming growth factor β signaling pathway. J. Biol. Chem. 272, 2896-2900.
26. Parsons, R., Myeroff, L.L., Liu, B., Willson, J.K., Markowitz, S.D., Kinzler, K.W., and Vogelstein, B. (1995). Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res. 55, 5548-5550.
27. Polyak, K., Xia, Y., Zweier, J.L., Kinzler, K.W., and Vogelstein, B. (1997). A model for p53 induced apoptosis. Nature 389, 300-304.
28. Riggins, G.J., Kinzler, K.W., Vogelstein, B., and Thiagalingam, S. (1997). Frequency of Smad gene mutations in human cancers. Cancer Res. 57, 2578-2580.
29. Savage, C., Das, P., Finelli, A.L., Townsend, S.R., Sun, C.Y., Baird, S.E., and Padgett, R.W. (1996). Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor β pathway components. Proc. Natl. Acad. Sci. USA 93, 790-794.
30. Sekelsky, J.J., Newfeld, S.J., Raftery, L.A., Chartoff, E.H., and Gelbart, W.M. (1995). Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139, 1347-1358.
31. Souchelnytskyi, S., Tamaki, K., Engstrom, L.J., Wernstedt, C., ten Dijke, P., and Heldin, C.H. (1997). Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J. Biol. Chem. 272, 28107-28115.
32. Thiagalingam, S., Lisitsyn, N.A., Hamaguchi, M., Wigler, M.H., Willson, J.K., Markowitz, S.D., Leach, F.S., Kinzler, K.W., and Vogelstein, B. (1996). Evaluation of the FHIT gene in colorectal cancers. Cancer Res. 56, 2936-2939.
33. Vize, P.D. (1996). DNA sequences mediating the transcriptional response of the Mix.2 homeobox gene to mesoderm induction. Dev. Biol. 177, 226-231.
34. Wang, J., Sun, L., Myeroff, L., Wang, X., Gentry, L.E., Yang, J., Liang, J., Zborowska, E., Markowitz, S., Willson, J.K., et al. (1995). Demonstration that mutation of the type Il transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J. Biol. Chem. 270, 22044-22049.
35. Zawel, L., Dai, J.L., Buckhaults, P., Zhou, S., Kiinzler, K.W., Vogelstein, B., and Kern, S.E. (1998). Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1, 611-617.
36. Zhou, S., Buckhaults, P., Zawel, L., Bunz, F., Riggins, G., Dai, J.L., Kern, S.E., Kinzler, K.W., and Vogelstein, B. (1998). Targeted deletion of Smad4 shows it is required for TGF-β and activin signaling in colorectal cancer cells. Proc. Natl. Acad. Sci. USA 95, 2412-2416.