Cellular senescence mechanisms independent of telomere shortening and telomerase: Other barriers to cell immortalization and carcinogenesis

Journal of Anti-Aging Medicine

Volumn 3, Issue 4, 2000, Pages 373-382

  Horikawa, I ^a,b   Yawata, T ^a,b   Barrett, J C ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16; TELOMERASE;

CANCER; CANCER INHIBITION; CARCINOGENESIS; CELL AGING; CELL CYCLE; CELL IMMORTALIZATION; CHROMOSOME ANALYSIS; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVIEW; TELOMERE;

RODENTIA;

EID: 0034503870     PISSN: 10945458     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.1.2000.3.373     Document Type: Review

References (89)

1. Replicative senescence and cell immortality: The role of telomeres and telomerase
2. Telomerase and cancer: Revising the telomere hypothesis
3. Evidence for the recessive nature of cellular immortality
4. Multiple pathways to cellular senescence: Role of telomerase repressors
5. Genetic analysis of indefinite division in human cells: Identification of four complementation groups
6. Evidence for multiple pathways to cellular senescence
7. Telomere loss: Mitotic clock or genetic time bomb?
8. Extension of life-span by introduction of telomerase into normal human cells
9. Telomere shortening apoptosis in telomerase-inhibited human tumor cells
10. Inhibition of telomerase limits the growth of human cancer cells
11. Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence
12. Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells
13. Introduction of chromosome 7 suppresses telomerase with shortening of telomeres in a human mesothelial cell line
14. Telomerase-independent senescence of human immortal cells induced by microcell-mediated chromosome transfer
15. Mapping a novel cellular-senescence gene to human chromosome 2q37 by irradiation microcell-mediated chromosome transfer
16. INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
17. A reassessment of the telomere hypothesis of senescence
18. Cellular senescence in telomerase-expressing Syrian hamster embryo cells
19. A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization
20. Inactivation of p16 in human mammary epithelial cells by CpG island methylation
21. CDKN2 expression and its implications for cell immortalization senescence
22. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
23. INK4A
24. Reexpression of the retinoblastoma protein in tumor cells induces senescence telomerase inhibition
25. ARF
26. CIP1 in spontaneously immortalized human fibroblasts
27. INK4a-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
28. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
29. Nucleolar Arf sequesters Mdm2 and activates p53
30. INK4a
31. ARF tumor suppressor
32. ARF act in overlapping pathways in cellular immortalization
33. INK4A upon immortalization
34. Replicative senescence as a barrier to human cancer
35. Ha
36. p53-independent role of MDM2 in TGF-β1 resistance
37. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging
38. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
39. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
40. Papillomavirus infections - A major cause of human cancers
41. A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts
42. Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent
43. INK4a enrichment and the premature senescence of normal fibroblasts
44. Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells
45. ink4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state
46. CIP1 in spontaneously immortalized human fibroblasts
47. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
48. Senescence of human fibroblasts induced by oncogenic Raf
49. Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts
50. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
51. Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments
52. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
53. Telomere loss in cells treated with cisplatin
54. ARF links the tumour suppressors RB and p53
55. ARF links the tumour suppressor p53 to Ras
56. DNA methylation decreases in aging but not in immortal cells
57. Levels of DNA methylation in diploid and SV40 transformed human fibroblasts
58. Replicative senescence: Considerations relating to the stability of heterochromatin domains
59. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
60. Evidence for the accumulation of oxidative stress during cellular ageing of human diploid fibroblasts
61. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
62. Aging: Is oxidative stress a marker or is it causal?
63. The aging paradox: Free radical theory of aging
64. Mechanisms of life span determination in Caenorhabditis elegans
65. Gene expression profile of aging its retardation by caloric restriction
66. Elevated oxidative stress in models of normal brain aging Alzheimer's disease
67. Extrachromosomal rDNA circles - A cause of aging in yeast
68. Hypervariable ultra-long telomeres in mice
69. Mammalian telomerase: Catalytic subunit knockout mice
70. Telomere structure and telomerase expression during mouse development and tumorigenesis
71. Telomere shortening tumor formation by mouse cells lacking telomerase RNA
72. Thermosensitivity of nuclear RNA polymerase during the in vitro senescence of mouse fibroblasts
73. Severe growth defect in mouse cells lacking the telomerase RNA component
74. Developmental and tissue-specific regulation of mouse telomerase and telomere length
75. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
76. Telomerase in cancer: Clinical applications
77. Role of telomerase in cellular proliferation and cancer
78. Adenoviral vector containing wild-type p16 suppresses prostate cancer growth and prolongs survival by inducing cell senescence
79. WAF1 and superoxide dismutases
80. sdil gene induces senescence-like state in human cancer cells: Implication for senescence-directed molecular therapy for cancer
81. INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis
82. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
83. Human endothelial cell life extension by telomerase expression
84. Creation of human tumour cells with defined genetic elements
85. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
86. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
87. Risky immortalization by telomerase
88. Telomerase activity is sufficient to allow transformed cells to escape from crisis
89. TRF2 protects human telomeres from end-to-end fusions