Role of the alternative INK4A proteins in human keratinocyte senescence: Evidence for the specific inactivation of p16(INK4A) upon immortalization

Cancer Research

Volumn 59, Issue 11, 1999, Pages 2516-2521

  Munro, June ^a   Stott, Francesca J ^b   Vousden, Karen H ^c   Peters, Gordon ^b   Parkinson, E Kenneth ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16;

ARTICLE; CELL AGING; CELL IMMORTALIZATION; CELL PROLIFERATION; CHROMOSOME 9P; GENE DELETION; GENE INACTIVATION; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN STABILITY; SENESCENCE; TARGET CELL;

3T3 CELLS; ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL AGING; CELL LINE, TRANSFORMED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; EXONS; GENE DELETION; HUMANS; KERATINOCYTES; MICE; PROTEINS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033152226     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Loughran, O., Edington, K. G., Berry, I. J., Clark, L. J., and Parkinson, E. K. Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes. Cancer Res., 54: 5045-5049, 1994.
2. INK4A with human head and neck keratinocyte replicative senescence: relationship of the dysfunction to immortality and neoplasia. Oncogene, 13: 561-568, 1996.
3. Serrano, M., Lee, H. W., Chin, L., Cordon-Cardo, C., Beach, D., and DePinho, R. A. Role of the INK4A locus in tumor suppression and cell mortality. Cell, 85: 27-37, 1996.
4. ARF. Cell, 91: 649-659, 1997.
5. Reed, A., Califano, J., Cairns, P., Westra, W. H., Jones, R., Koch, W., Bartek, J., and Sidransky, D. High frequency of p16 (CDKN2/MTS-1/1NK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res., 56: 3630-3633, 1996.
6. CDKN2 expression and its implications for cell immortalisation and senescence. Mol. Cell. Biol., 16: 859-867, 1996.
7. Liggett, W. H., Jr., Sewell, D. A., Rocco, J., Ahrendt, S. A., Koch, W., and Sidransky, D. p16 and p16β are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Res., 56: 4119-4122, 1996.
8. INK4A/MTS1 gene. Oncogene, 15: 2475-2481, 1997.
9. ARF, participates in a regulatory feedback loop with p53 and MDM2. EMBO J., 17: 5001-5014, 1998.
10. Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., and Roussel, M. F. Myc signalling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev., 12: 2424-2433, 1998.
11. ARF links the tumour-suppressor p53 to ras. Nature (Lond.), 395: 125-126, 1998.
12. INK4A. Cell, 88: 593-602, 1997.
13. Loughran, O., Clark, L. J., Bond, J., Baker, A., Berry, I. J., Edington, K. G., Ly, I-S., Simmons, R., Haw, R., Black, D. M., Newbold, R. F., and Parkinson, E. K. Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes. Oncogene, 14: 1955-1964, 1997.
14. Kubo, Y., Urano, Y., Matsumoto, K., Ahsan, K., and Arase, S. Mutations of the INK4A locus in squamous cell carcinomas of human skin. Biochem. Biophys. Res. Commun., 232: 38-41, 1997.
15. Vaziri, H., West, M. D., Allsopp, R. C., Davison, T. S., Wu, Y-S., Arrowsmith, C. H., Poirier, G. G., and Benchimol, S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J., 16: 6018-6033, 1997.
16. Gire, V., and Wynford-Thomas, D. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol. Cell. Biol., 18: 1611-1621, 1998.
17. Arap, W., Knudsen, E., Sewell, D. A., Sidransky, D., Wang, J. Y. J., Huang, H. J. S., and Cavanee, W. K. Functional analysis of wild-type and malignant glioma derived CDKN2A alleles: evidence for an RB-independent growth suppressive pathway. Oncogene, 15: 2013-2020, 1997.
18. ARF. Proc. Natl. Acad. Sci. USA, 94: 669-673, 1997.
19. Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichsteiner, S., and Wright, W. E. Extension of life-span by introduction of telomerase into normal human cells. Science (Washington DC), 279: 349-352, 1998.
20. Kipling, D., and Cooke, H. J. Hypervariable ultra-long telomeres in mice. Nature (Lond.), 347: 400-402, 1990.