Telomerase-independent senescence of human immortal cells induced by microcell-mediated chromosome transfer

Molecular Carcinogenesis

Volumn 25, Issue 4, 1999, Pages 249-255

  Tanaka, Hiromi ^a   Horikawa, Izumi ^b   Kugoh, Hiroyuki ^a   Shimizu, Motoyuki ^c   Barrett, J Carl ^b   Oshimura, Mitsuo ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c NIPPON DENTAL UNIVERSITY   (Japan)

Author keywords

Chromosome transfer; Senescence; Telomerase; Telomere; Tumor cells

Indexed keywords

BETA GALACTOSIDASE; ONCOPROTEIN; PROTEIN P53; TELOMERASE;

ARTICLE; CELL GROWTH; CELL IMMORTALIZATION; CELL MATURATION; CELL STRUCTURE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TELOMERE; TUMOR CELL;

CELL AGING; CELL LINE, TRANSFORMED; GENE TRANSFER TECHNIQUES; HUMANS; HYBRID CELLS; TELOMERASE;

EID: 0032796133     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199908)25:4<249::AID-MC3>3.0.CO;2-Z     Document Type: Article

References (46)

1. Chir C-P, Harley CB. Replicative senescence and cell immortality: The role of telomeres and telomerase. Proc Soc Exp Biol Med 1997;214:99-106.
2. Autexier C, Greider CW. Telomerase and cancer: Revisiting the telomere hypothesis. Trends Biochem Sci 1996;21: 387-391.
3. Blackburn EH. Structure and function of telomeres. Nature 1991;350:569-573.
4. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-2015.
5. Feng J, Funk WD, Wang S-S, et al. The RNA component of human telomerase. Science 1995;269:1236-1241.
6. Harrington L, McPhail T, Mar V, et al. A mammalian telomerase-associated protein. Science 1997;275: 973-977.
7. Nakayama J, Saito M, Nakamura H, Matsuura A, Ishikawa F. TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 1997;88:875-884.
8. Meyerson M, Counter CM, Eaton EN, et al. hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization. Cell 1997;90:785-795.
9. Nakamura TM, Morin GB, Chapman KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997;277:955-959.
10. Weinrich SL, Pruzan R, Ma L, et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 1997;17:498-502.
11. Nakayama J, Tahara H, Tahara E, et al. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 1998;18:65-68.
12. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of lifespan by introduction of telomerase into normal human cells. Science 1998;279:349-352.
13. Ohmura H, Tahara H, Suzuki M, et al. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res 1995;86:899-904.
14. Tanaka H, Shimizu M, Horikawa I, et al. Evidence for a putative telomerase repressor gene in the 3p14.2-p21.1 region. Genes Chromosomes Cancer 1998;23:123-133.
15. Horikawa I, Oshimura M, Barrett JC. Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence. Mol Carcinog 1998;22:65-72.
16. INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998;396:84-88.
17. Uejima H, Mitsuya K, Kugoh H, Horikawa I, Oshimura M. Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line SiHa. Genes Chromosomes Cancer 1995;14:120-127.
18. Matsuda T, Sasaki M, Kato H, et al. Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma. Oncogene 1997;15:2773-2781.
19. Kakuya T, Yamada T, Yokokawa M, Ueda T. Establishment of cell strains from human urothelial carcinoma and their morphological characterization. In Vitro 1983;19:591-599.
20. Koi M, Shimizu M, Morita H, Yamada H, Oshimura M. Construction of mouse A9 clones containing a single human chromosome tagged with neomycin-resistance gene via microcell fusion. Jpn J Cancer Res 1989;80:413-418.
21. Polymeropoulos MH, Rath DS, Xiao H, Merril CR. Dinucleotide repeat polymorphism at the human preproglucagon gene. Nucleic Acids Res 1991;19:688.
22. Polymeropoulos MH, Xaio H, Rath DS, Merril CR. Tetranudeotide repeat polymorphism at the human tyrosine hydroxylase gene (TH). Nucleic Acids Res 1991;19:3753.
23. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92:9363-9367.
24. Wright WE, Shay JW, Piatyszek MA. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res 1995;23:3794-3795.
25. Cuthbert AP, Bond J, Trott DA, et al. Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells. J Natl Cancer Inst 1999;91:37-45.
26. CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol 1996; 16:859-867.
27. Sugrue MM, Shin DY, Lee SW, Aaronson SA. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc Natl Acad Sci USA 1997;94: 9648-9653.
28. INK4A. Oncogene 1997;15:505-514.
29. Xu HJ, Zhou Y, Ji W, et al. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene 1997;15: 2589-2596.
30. ARF. Cell 1997;91:649-659.
31. CIP1 in spontaneously immortalized human fibroblasts. Cell Growth Differ 1998;9:139-146.
32. Horikawa I, Suzuki M, Oshimura M. An amino-terminally truncated p53 protein expressed in a human choriocarcinoma cell line, CC1. Hum Mol Genet 1995;4:313-314.
33. Seedorf K, Oltersdorf T, Krammer G, Rowekamp W. Identification of early proteins of the human papilloma viruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells. EMBO J 1987;6:139-144.
34. zur Hausen H. Papillomavirus infections - A major cause of human cancers. Biochim Biophys Acta 1996;1288: F55-F78.
35. Sasaki M, Honda T, Yamada H, Wake N, Barrett JC, Oshimura M. Evidence for multiple pathways to cellular senescence. Cancer Res 1994;54:6090-6093.
36. Tresini M, Mawal-Dewan M, Cristofalo VJ, Sell C. A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts. Cancer Res 1998;58:1-4.
37. Ogryzko W, Hirai TH, Russanova VR, Barbie DA, Howard BH. Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent. Mol Cell Biol 1996;16: 5210-5218.
38. INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 1998;16: 1113-1123.
39. Wang X, Wong SCH, Pan J, et al. Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells. Cancer Res 1998;58:5019-5022.
40. Chen Q, Ames BN. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA 1994;91:4130-4134.
41. Wilson VL, Jones, PA. DNA methylation decreases in aging but not in immortal cells. Science 1983;220:1055-1057.
42. INK4a. Cell 1997;88:593-602.
43. Zhu J, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 1998;12:2997-3007.
44. Carman TA, Afshari CA, Barrett JC. Cellular senescence in telomerase-expressing Syrian hamster embryo cells. Exp Cell Res 1998;244:33-42.
45. Russo I, Silver ARJ, Cuthbert, AP, Griffin DK, Trott DA, Newbold RF. A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization. Oncogene 1998;17:3417-3426.
46. Horikawa I, Suzuki M, Yoshida MA, Oshimura M. Frameshift mutation and reduced transcript of p53 gene in a renal cell carcinoma cell line, RCC23. Hum Mol Genet 1995; 4:771-773.