Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence

Molecular Carcinogenesis

Volumn 22, Issue 2, 1998, Pages 65-72

  Horikawa, Izumi ^a   Oshimura, Mitsuo ^b   Barrett, J Carl ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

Chromosome transfer; Renal cell carcinoma; Telomerase activity; Telomerase components; Telomere shortening

Indexed keywords

BETA GALACTOSIDASE; DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; RNA; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ARTICLE; CARCINOMA CELL; CELL AGING; CHROMOSOME 3; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME REPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PRIORITY JOURNAL; TELOMERE;

CARCINOMA, RENAL CELL; CELL AGING; CHROMOSOMES, HUMAN, PAIR 3; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY NEOPLASMS; POLYMERASE CHAIN REACTION; PROTEINS; RNA; TELOMERASE; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0031835444     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199806)22:2<65::AID-MC1>3.0.CO;2-J     Document Type: Article

References (33)

1. Chiu C-P, Harley CB. Replicative senescence and cell immortality: The role of telomeres and telomerase. Proc Soc Exp Biol Med 214:99-106, 1997.
2. Autexier C, Greider CW. Telomerase and cancer: Revisiting the telomere hypothesis. Trends Biochem Sci 21:387-391, 1996.
3. Pereira-Smith OM, Smith JR. Evidence for the recessive nature of cellular immortality. Science 221:964-966, 1983.
4. Pereira-Smith OM, Smith JR. Genetic analysis of indefinite division in human cells: Identification of four complementation groups. Proc Natl Acad Sci USA 85:6042-6046, 1988.
5. Oshimura M, Barrett JC. Multiple pathways to cellular senescence: Role of telomerase repressors. Eur J Cancer 33:710-715, 1997.
6. INK4A). Carcinogenesis 17:1567-1575, 1996.
7. Ohmura H, Tahara H, Suzuki M, et al. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res 86:899-904, 1995.
8. Hensler PJ, Annab LA, Barrett JC, Pereira-Smith OM. A gene involved in control of human cellular senescence on human chromosome 1q. Mol Cell Biol 14:2291-2297, 1994.
9. König P, Rhodes D. Recognition of telomeric DNA. Trends Biochem Sci 22:43-47, 1997.
10. Makarov HL, Hirose Y, Langmore JP. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88:657-666, 1997.
11. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015, 1994.
12. Feng J, Funk WD, Wang S-S, et al. The RNA component of human telomerase. Science 269:1236-1241, 1995.
13. Harrington L, McPhail T, Mar V, et al. A mammalian telomerase-associated protein. Science 275:973-977, 1997.
14. Nakayama J-I, Saito M, Nakamura H, Matsuura A, Ishikawa F. TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 88:875-884, 1997.
15. Meyerson M, Counter CM, Eaton EN, et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90:785-795, 1997.
16. Nakamura TM, Morin GB, Chapman KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 277:955-959, 1997.
17. Kilian A, Bowtell DDL, Abud HE, et al. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet 6:2011-2019, 1997.
18. Harrington L, Zhou W, McPhail T, et al. Human telomerase contains evolutionary conserved catalytic and structural subunits. Genes Dev 11:3109-3115, 1997.
19. Weinrich SL, Pruzan R, Ma L, et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 17:498-502, 1997.
20. Nakayama J-I, Tahara H, Tahara E, et al. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 18:65-68, 1998.
21. Yoshida MA, Shimizu M, Ikeuchi T, Tonomura A, Yokota J, Oshimura M. In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell fusion. Mol Carcinog 9:114-121, 1994.
22. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging in vivo. Proc Natl Acad Sci USA 92:9363-9367, 1995.
23. Albanell J, Han W, Mellado B, et al. Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines. Cancer Res 56:1503-1508, 1996.
24. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987.
25. West MD, Shay JW, Wright WE, Linskens MH. Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence. Exp Gerontol 31:175-193, 1996.
26. Kumazaki T, Kobayashi M, Mitsui Y. Enhanced expression of fibronectin during in vivo cellular aging of human vascular endothelial cells and skin fibroblasts. Exp Cell Res 205:396-402, 1993.
27. Thweatt R, Lumpkin CK Jr, Goldstein S. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. Biochem Biophys Res Commun 187:1-7, 1992.
28. Tanaka H, Shimizu M, Horikawa I, et al. Evidence for a putative telomerase repressor gene on the 3p14.2-p21.1 region. Genes Chromosomes Cancer, in press.
29. Ohta M, Inoue H, Cotticelli MG, et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 84:587-597, 1996.
30. van den Berg A, Buys CHCM. Involvement of multiple loci on chromosome 3 in renal cell cancer development. Genes Chromosomes Cancer 19:59-76, 1997.
31. Todd S, Franklin WA, Varella-Garcia M, et al. Homozygous deletions of human chromosome 3p in lung tumors. Cancer Res 57:1344-1352, 1997.
32. Loughran O, Clark LJ, Bond J, et al. Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes. Oncogene 14:1955-1964, 1997.
33. Steenbergen RDM, Walboomers JMM, Meijer CJLM, et al. Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: Activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q. Oncogene 13:1249-1257, 1996.