Cellular senescence in telomerase-expressing Syrian hamster embryo cells

Experimental Cell Research

Volumn 244, Issue 1, 1998, Pages 33-42

  Carman, T A ^a,b   Afshari, C A ^b   Barrett, J C ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Rodent telomerase; Senescence; Syrian hamster embryo cells; Telomerase; Telomeres

Indexed keywords

TELOMERASE;

ANIMAL CELL; ARTICLE; CELL AGING; CELL POPULATION; CELL PROLIFERATION; CELL STIMULATION; EMBRYO; EMBRYO CELL; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYRIAN HAMSTER; TELOMERE;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS; RODENTIA;

EID: 0032505717     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4207     Document Type: Article

References (46)

1. Hayflick, L., and Moorhead, P. S. (1961). The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621.
2. Sasaki, M., Honda, T., Yamada, H., Wake, N., Barrett, J. C., and Oshimura, M. (1994). Evidence for multiple pathways to cellular senescence. Cancer Res. 54, 6090-6093.
3. Vojta, P. J., and Barrett, J. C. (1995). Genetic analysis of cellular senescence. Biochim. Biophys. Acta 1242, 29-41.
4. Zakian, V. A. (1989). Structure and function of telomeres. Annu. Rev. Genet. 23, 579-604.
5. Harrington, L. A., and Greider, C. W. (1991). Telomerase primer specificity and chromosome healing. Nature 353, 451-454.
6. Blackburn, E. H. (1991). Structure and function of telomeres. Nature 350, 569-573.
7. Olovnikov, A. M. (1971). [Principle of marginotomy in template synthesis of polynucleotides.] Dokl. Akad. Nauk. SSSR 201, 1496-1499.
8. Watson, J. D. (1972). Origin of concatemeric T7 DNA. Nat. New Biol. 239, 197-201.
9. Greider, C. W. (1990). Telomeres, telomerase and senescence. BioEssays 12, 363-369.
10. Tseng, B. Y., Erickson, J. M., and Goulian, M. (1979). Initiator RNA of nascent DNA from animal cells. J. Mol. Biol. 129, 531-545.
11. Makarov, V. L., Hirose, Y., and Langmore, J. P. (1997). Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88, 657-666.
12. Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., and Harley, C. B. (1992). Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA 89, 10114-10118.
13. Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., and Bacchetti, S. (1992). Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929.
14. Harley, C. B., Futcher, A. B., and Greider, C. W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460.
15. de Lange, T., Shiue, L., Myers, R. M., Cox, D. R., Naylor, S. L., Killery, A. M., and Varmus, H. E. (1990). Structure and variability of human chromosome ends. Mol. Cell. Biol. 10, 518-527.
16. Greider, C. W., and Blackburn, E. H. (1985). Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405-413.
17. Morin, G. B. (1989). The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59, 521-529.
18. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. (1994). Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015.
19. Klingelhutz, A. J., Barber, S. A., Smith, P. P., Dyer, K., and McDougall, J. K. (1994). Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells. Mol. Cell. Biol. 14, 961-969.
20. Counter, C. M., Botelho, F. M., Wang, P., Harley, C. B., and Bacchetti, S. (1994). Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J. Virol. 68, 3410-3414.
21. Bryan, T., Englezou, A., Gupta, J., Bacchetti, S., and Reddell, R. (1995). Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240-4248.
22. Wright, W. E., Brasiskyte, D., Piatyszek, M. A., and Shay, J. W. (1996). Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids. EMBO J. 15, 1734-1741.
23. Ohmura, H., Tahara, H., Suzuki, M., Ide, T., Shimizu, M., Yoshida, M., Tahara, E., Shay, J., Barrett, J., and Oshimura, M. (1995). Restoration of cellular senescence and repression of telomerase by human chromosome 3. Jpn. J. Cancer Res. 86, 898-904.
24. Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright, W. E. (1998). Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.
25. Berry, I. J., Burns, J. E., and Parkinson, E. K. (1994). Assignment of two human epidermal squamous cell carcinomas cell lines to more than one complementation group for the immortal phenotype. Mol. Carcinog. 9, 134-142.
26. Duncan, E. L., Whitaker, N. J., Moy, E. L., and Reddel, R. R. (1993). Assignment of SV40-immortalized cells to more than one complementation group for immortalization. Exp. Cell Res. 205, 337-344.
27. Barrett, J. C., Crawford, B. D., Mixter, L. O., Schectman, L. M., Ts'O, P. O. P., and Pollack, R. (1979). Correlation of in vitro growth properties and tumorigenicity of Syrian hamster cell lines. Cancer Res. 39, 1504-1510.
28. Tsutsui, T., Barrett, J. C., and Ts'o, P. O. (1978). Induction of 6-thioguanine- and ouabain-resistant mutations in synchronized Syrian hamster cell cultures during different periods of the S phase. Mutat. Res. 52, 255-264.
29. Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., and Barrett, J. C. (1996). Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA 93, 13742-13747.
30. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira Smith, O., et al. (1995). A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92, 9363-9367.
31. Birren, B., and Lai, E. (1993). "Pulsed Field Gel Electrophoresis-A Practical Guide," Academic Press, San Diego.
32. Prowse, K. R., Avilion, A. A., and Greider, C. W. (1993). Identification of a nonprocessive telomerase activity from mouse cells. Proc. Natl. Acad. Sci. USA 90, 1493-1497.
33. Shampay, J., Schmitt, M., and Bassham, S. (1995). A novel minisatellite at a cloned hamster telomere. Chromosoma 104, 29-38.
34. Kipling, D., and Cooke, H. J. (1990). Hypervariable ultra-long telomeres in mice. Nature 347, 400-402.
35. Isfort, R. J., Kerckaert, G., Anderson, N. L., and LeBoeuf, R. A. (1992). Two-dimensional gel electrophoresis analysis of Syrian hamster embryo cells: Morphological transformation is not cell type specific. Electrophoresis 13, 855-861.
36. Gilley, D., and Blackburn, E. H. (1994). Lack of telomere shortening during senescence in Paramecium. Proc. Natl. Acad. Sci. USA 91, 1955-1958.
37. Schwartz, T., and Osiewacz, H. D. (1996). Telomere length does not change during senescence of the ascomycete Podospora anserina. Mutat. Res. 316, 193-199.
38. Pan, C., Xue, B. H., Ellis, T. M., Peace, D. J., and Diaz, M. O. (1997). Changes in telomerase activity and telomere length during human T lymphocyte senescence. Exp. Cell Res. 231, 346-353.
39. Chiu, C. P., Dragowska, W., Kim, N. W., Vaziri, H., Yui, J., Thomas, T. E., Harley, C. B., and Lansdorp, P. M. (1996). Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells 14, 239-248.
40. Zijlmans, J. M., Martens, U. M., Poon, S. S., Raap, A. K., Tanke, H. J., Ward, R. K., and Lansdorp, P. M. (1997). Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc. Natl. Acad. Sci. USA 94, 7423-7428.
41. von Zglinicki, T., Saretzki, G., Docke, W., and Lotze, C. (1995). Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence? Exp. Cell Res. 220, 186-193.
42. Petersen, S., Saretzki, G., and von Zglinicki, T. (1998). Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp. Cell Res. 239, 152-160.
43. Di Leonardo, A., Linke, S. P., Clarkin, K., and Wahl, G. M. (1994). DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540-2551.
44. Chen, Q., and Ames, B. N. (1994). Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc. Natl. Acad. Sci. USA 91, 4130-4134.
45. Chen, Q., Fischer, A., Reagan, J. D., Yan, L. J., and Ames, B. N. (1995). Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc. Natl. Acad. Sci. USA 92, 4337-4341.
46. Wilson, V. L., and Jones, P. A (1983). DNA methylation decreases in aging but not in immortal cells. Science 220, 1055-1057.