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Volumn 34, Issue 3, 1999, Pages 293-303

The aging paradox: Free radical theory of aging

Author keywords

Aging; Autoantibodies; DNA damage; Free radicals; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; AUTOANTIBODY; FREE RADICAL;

EID: 0033015743     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(99)00005-4     Document Type: Review
Times cited : (270)

References (74)
  • 1
    • 0031823387 scopus 로고    scopus 로고
    • Detection of oxidative DNA damage by a monoclonal antibody: Role of lysyl residues in antigen binding
    • Ahmad J., Ashok B.T., Ali R. Detection of oxidative DNA damage by a monoclonal antibody Role of lysyl residues in antigen binding . Immunol Lett. 62:1998;87-92.
    • (1998) Immunol Lett , vol.62 , pp. 87-92
    • Ahmad, J.1    Ashok, B.T.2    Ali, R.3
  • 2
    • 0024366182 scopus 로고
    • Mutagenesis and carcinogenesis: Endogenous and exogenous factors
    • Ames B.N. Mutagenesis and carcinogenesis Endogenous and exogenous factors . Environ Mol Mutagen. 14:1989;66-77.
    • (1989) Environ Mol Mutagen , vol.14 , pp. 66-77
    • Ames, B.N.1
  • 3
    • 0027017938 scopus 로고
    • Age-related variations of enzymatic defences against free radicals and peroxides
    • I. Emerit, & B. Chance. Basel, Switzerland: Birkhauser Verlag
    • Artur Y., Herbeth B., Guemouri L., Leconte E., Jeandel C., Siest G. Age-related variations of enzymatic defences against free radicals and peroxides. Emerit I., Chance B. Free Radicals and Aging. 1992;359-367 Birkhauser Verlag, Basel, Switzerland.
    • (1992) Free Radicals and Aging , pp. 359-367
    • Artur, Y.1    Herbeth, B.2    Guemouri, L.3    Leconte, E.4    Jeandel, C.5    Siest, G.6
  • 4
    • 0031465858 scopus 로고    scopus 로고
    • Anti-ROS-DNA monoclonal antibody as molecular probe for oxidative DNA damage
    • Ashok B.T., Ahmad J., Qadri A., Ali R. Anti-ROS-DNA monoclonal antibody as molecular probe for oxidative DNA damage. Biochem Mol Biol Int. 43:1997;1219-1229.
    • (1997) Biochem Mol Biol Int , vol.43 , pp. 1219-1229
    • Ashok, B.T.1    Ahmad, J.2    Qadri, A.3    Ali, R.4
  • 5
    • 0031755803 scopus 로고    scopus 로고
    • Binding of human anti-DNA autoantibodies to reactive oxygen species modified DNA and probing oxidative DNA damage in cancer using monoclonal antibody
    • Ashok B.T., Ali R. Binding of human anti-DNA autoantibodies to reactive oxygen species modified DNA and probing oxidative DNA damage in cancer using monoclonal antibody. Int J Cancer. 78:1998;404-409.
    • (1998) Int J Cancer , vol.78 , pp. 404-409
    • Ashok, B.T.1    Ali, R.2
  • 6
    • 0032100662 scopus 로고    scopus 로고
    • Binding of circulating antibodies to reactive oxygen species modified-DNA and detecting DNA damage by a monoclonal antibody probe
    • Ashok B.T., Ali R. Binding of circulating antibodies to reactive oxygen species modified-DNA and detecting DNA damage by a monoclonal antibody probe. Mech Ageing Dev. 103:1998;69-80.
    • (1998) Mech Ageing Dev , vol.103 , pp. 69-80
    • Ashok, B.T.1    Ali, R.2
  • 7
    • 0032979458 scopus 로고    scopus 로고
    • Antigen binding characteristics of experimentally-induced antibodies against hydroxyl radical modified native DNA
    • (In Press)
    • Ashok, B. T. & Ali, R. (1999). Antigen binding characteristics of experimentally-induced antibodies against hydroxyl radical modified native DNA. Autoimmunity (In Press).
    • (1999) Autoimmunity
    • Ashok, B.T.1    Ali, R.2
  • 8
    • 0029052508 scopus 로고
    • Chromium-induced excretion of urinary lipid metabolites, DNA damage, nitric oxide production, and generation of reactive oxygen species in Sprague-Dawley rats
    • Bagchi D., Hassoun E.A., Bagchi M., Stohs S. Chromium-induced excretion of urinary lipid metabolites, DNA damage, nitric oxide production, and generation of reactive oxygen species in Sprague-Dawley rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 110:1995;177-187.
    • (1995) Comp Biochem Physiol C Pharmacol Toxicol Endocrinol , vol.110 , pp. 177-187
    • Bagchi, D.1    Hassoun, E.A.2    Bagchi, M.3    Stohs, S.4
  • 9
    • 0024319235 scopus 로고
    • Cerebral enzyme antioxidant system. Influence of aging and phosphatidylcholine
    • Benzi G., Pastoris O., Marzatico F., Villa R.F. Cerebral enzyme antioxidant system. Influence of aging and phosphatidylcholine. J Cer Blood Flow Metabolism. 9:1989;373-380.
    • (1989) J Cer Blood Flow Metabolism , vol.9 , pp. 373-380
    • Benzi, G.1    Pastoris, O.2    Marzatico, F.3    Villa, R.F.4
  • 11
    • 0027024786 scopus 로고
    • Genetic stability and oxidative stress: Common mechanisms in aging and cancer
    • I. Emerit, & B. Chance. Basel, Switzerland: Birkhauser Verlag
    • Cutler R.G. Genetic stability and oxidative stress Common mechanisms in aging and cancer . Emerit I., Chance B. Free Radicals and Aging. 1992;31-46 Birkhauser Verlag, Basel, Switzerland.
    • (1992) Free Radicals and Aging , pp. 31-46
    • Cutler, R.G.1
  • 12
    • 0026390290 scopus 로고
    • Human longevity and aging: Possible role of reactive oxygen species
    • Cutler R.G. Human longevity and aging Possible role of reactive oxygen species . Ann N Y Acad Sci. 621:1991;1-28.
    • (1991) Ann N Y Acad Sci , vol.621 , pp. 1-28
    • Cutler, R.G.1
  • 13
    • 0026008160 scopus 로고
    • Antioxidants and aging
    • Cutler R.G. Antioxidants and aging. Am J Clin Nutr. 53:1991;373s-379s.
    • (1991) Am J Clin Nutr , vol.53
    • Cutler, R.G.1
  • 14
    • 0021777459 scopus 로고
    • Antioxidants and longevity of mammalian species
    • A.D. Woodhead, A.D. Blackett, & A. Hollaender. New York: Plenum Press
    • Cutler R.G. Antioxidants and longevity of mammalian species. Woodhead A.D., Blackett A.D., Hollaender A. Molecular Biology of Aging. 1985;15-73 Plenum Press, New York.
    • (1985) Molecular Biology of Aging , pp. 15-73
    • Cutler, R.G.1
  • 15
    • 0004437641 scopus 로고
    • Peroxide-producing potential of tissues: Correlation with longevity of mammalian species
    • Cutler R.G. Peroxide-producing potential of tissues Correlation with longevity of mammalian species . Proc Natl Acad Sci USA. 82:1985;4798-4802.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 4798-4802
    • Cutler, R.G.1
  • 16
    • 0030988742 scopus 로고    scopus 로고
    • Biochemistry and pathology of radical-mediated protein oxidation
    • Dean R.T., Fu S., Stocker R., Davies M.J. Biochemistry and pathology of radical-mediated protein oxidation. Biochem J. 324:1997;1-18.
    • (1997) Biochem J , vol.324 , pp. 1-18
    • Dean, R.T.1    Fu, S.2    Stocker, R.3    Davies, M.J.4
  • 17
    • 0025973703 scopus 로고
    • Chemical determination of free radical induced damage to DNA
    • Dizdaroglu M. Chemical determination of free radical induced damage to DNA. Free Radic Biol Med. 10:1991;225-242.
    • (1991) Free Radic Biol Med , vol.10 , pp. 225-242
    • Dizdaroglu, M.1
  • 18
    • 0029998738 scopus 로고    scopus 로고
    • Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes
    • Duthie S.J., Ma A., Ross M.A., Collins A.R. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res. 56:1996;1291-1295.
    • (1996) Cancer Res , vol.56 , pp. 1291-1295
    • Duthie, S.J.1    Ma, A.2    Ross, M.A.3    Collins, A.R.4
  • 21
    • 0025373259 scopus 로고
    • Oxidative damage to DNA during aging: 8-Hydroxy-2′-deoxyguanosine in rat organ DNA and urine
    • Fraga C.G., Shigenaga M.K., Park J.W., Degan P., Ames B.N. Oxidative damage to DNA during aging 8-Hydroxy-2′-deoxyguanosine in rat organ DNA and urine . Proc Natl Acad Sci USA. 87:1990;4533-4537.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 4533-4537
    • Fraga, C.G.1    Shigenaga, M.K.2    Park, J.W.3    Degan, P.4    Ames, B.N.5
  • 22
    • 0018667684 scopus 로고
    • Fate during cell growth of yeast mitochondria and nuclear DNA after photolytic attachment of the monazide analog of ethidium
    • Fukanaga M., Yielding K.L. Fate during cell growth of yeast mitochondria and nuclear DNA after photolytic attachment of the monazide analog of ethidium. Biochem Biophys Res Commun. 90:1979;582-586.
    • (1979) Biochem Biophys Res Commun , vol.90 , pp. 582-586
    • Fukanaga, M.1    Yielding, K.L.2
  • 23
    • 0023215858 scopus 로고
    • Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer
    • Gey K.F., Brubacher G.B., Stahelin H.B. Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. Am J Clin Nutr. 45:1987;1368-1377.
    • (1987) Am J Clin Nutr , vol.45 , pp. 1368-1377
    • Gey, K.F.1    Brubacher, G.B.2    Stahelin, H.B.3
  • 24
    • 0026322413 scopus 로고
    • Biological variability of superoxide dismutase, glutathione peroxidase and catalase in blood
    • Guemouri L., Artur Y., Herbeth B., Jeandel C., Cuny G., Siest G. Biological variability of superoxide dismutase, glutathione peroxidase and catalase in blood. Clin Chem. 37:1991;1932-1937.
    • (1991) Clin Chem , vol.37 , pp. 1932-1937
    • Guemouri, L.1    Artur, Y.2    Herbeth, B.3    Jeandel, C.4    Cuny, G.5    Siest, G.6
  • 25
    • 0027723251 scopus 로고
    • Effect of dietary restriction on DNA repair and DNA damage
    • Haley-Zitlin V., Richardson A. Effect of dietary restriction on DNA repair and DNA damage. Mutation Res. 295:1993;237-245.
    • (1993) Mutation Res , vol.295 , pp. 237-245
    • Haley-Zitlin, V.1    Richardson, A.2
  • 26
    • 0026047662 scopus 로고
    • The aging process: Major risk factor for disease and death
    • Harman D. The aging process Major risk factor for disease and death . Proc Natl Acad Sci USA. 88:1991;5360-5363.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5360-5363
    • Harman, D.1
  • 27
    • 0020516814 scopus 로고
    • Free radical theory of aging: Consequences of mitochondrial aging
    • Harman D. Free radical theory of aging Consequences of mitochondrial aging . Age. 6:1983;86-94.
    • (1983) Age , vol.6 , pp. 86-94
    • Harman, D.1
  • 28
  • 29
    • 0015319592 scopus 로고
    • The biological clock: The mitochondria
    • Harman D. The biological clock The mitochondria . J Am Geriatr Soc. 20:1972;145-147.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 30
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging a theory based on free radical and radiation chemistry . J Gerontol. 11:1956;298-300.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 31
    • 0026522213 scopus 로고
    • Immune control of mammalian aging: A T-cell model
    • Hartwig M. Immune control of mammalian aging A T-cell model . Mech Ageing Dev. 63:1992;207-213.
    • (1992) Mech Ageing Dev , vol.63 , pp. 207-213
    • Hartwig, M.1
  • 32
    • 0028029279 scopus 로고
    • An age-related increase in the basal level of DNA damage and DNA vulnerability to oxygen radicals in the individual hepatocytes of male F344 rats
    • Higami Y., Shimokawa I., Okimoto T., Ikeda T. An age-related increase in the basal level of DNA damage and DNA vulnerability to oxygen radicals in the individual hepatocytes of male F344 rats. Mutation Res. 316:1994;59-67.
    • (1994) Mutation Res , vol.316 , pp. 59-67
    • Higami, Y.1    Shimokawa, I.2    Okimoto, T.3    Ikeda, T.4
  • 34
    • 0026698068 scopus 로고
    • Oxidative and other DNA damages as the basis of aging: A review
    • Holmes G.E., Bernstein C., Bernstein H. Oxidative and other DNA damages as the basis of aging A review . Mutation Res. 275:1992;305-315.
    • (1992) Mutation Res , vol.275 , pp. 305-315
    • Holmes, G.E.1    Bernstein, C.2    Bernstein, H.3
  • 35
    • 0019485602 scopus 로고
    • Serum vitamin A (retinol) and cancer incidence in Evans country, Georgia
    • Kark J.D., Smith A.H., Switzer B.R., Hames C.G. Serum vitamin A (retinol) and cancer incidence in Evans country, Georgia. J Natl Cancer Inst. 66:1981;7-16.
    • (1981) J Natl Cancer Inst , vol.66 , pp. 7-16
    • Kark, J.D.1    Smith, A.H.2    Switzer, B.R.3    Hames, C.G.4
  • 36
    • 0021751687 scopus 로고
    • Antibodies against ss-DNA in persons of various age
    • Kasjanov A., Cebecauer L., Balaz V. Antibodies against ss-DNA in persons of various age. Mech Ageing Dev. 28:1984;289-295.
    • (1984) Mech Ageing Dev , vol.28 , pp. 289-295
    • Kasjanov, A.1    Cebecauer, L.2    Balaz, V.3
  • 39
    • 0029886786 scopus 로고    scopus 로고
    • Cancer risk and oxidative DNA damage in man
    • Loft S., Poulsen S.E. Cancer risk and oxidative DNA damage in man. J Mol Med. 74:1996;297-312.
    • (1996) J Mol Med , vol.74 , pp. 297-312
    • Loft, S.1    Poulsen, S.E.2
  • 43
    • 0012631313 scopus 로고
    • Growth, aging, chronic diseases and life span in rats
    • McCay C.M., Sperling G., Barnes L.L. Growth, aging, chronic diseases and life span in rats. Arch Biochem Biophys. 469:1943;1943.
    • (1943) Arch Biochem Biophys , vol.469 , pp. 1943
    • McCay, C.M.1    Sperling, G.2    Barnes, L.L.3
  • 44
    • 0025117953 scopus 로고
    • An attempt at a rational classification of theories of aging
    • Medvedev Z.A. An attempt at a rational classification of theories of aging. Biol Rev. 65:1990;375-398.
    • (1990) Biol Rev , vol.65 , pp. 375-398
    • Medvedev, Z.A.1
  • 45
    • 0025864512 scopus 로고
    • An integrated theory of aging as the result of mitochondrial DNA mutation in differentiated cells
    • Miquel J. An integrated theory of aging as the result of mitochondrial DNA mutation in differentiated cells. Arch Gerontol Geriatr. 12:1991;99-177.
    • (1991) Arch Gerontol Geriatr , vol.12 , pp. 99-177
    • Miquel, J.1
  • 47
    • 0003138331 scopus 로고
    • Theoretical and experimental support for an "oxygen radical-mitochondrial injury" hypothesis of cell aging
    • In J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel (Eds.), New York: Alan R. Liss
    • Miquel, J. & Fleming, J. E. (1986). Theoretical and experimental support for an "oxygen radical-mitochondrial injury" hypothesis of cell aging. In J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel (Eds.), Free Radicals, Aging and Degenerative Diseases (pp. 51-74). New York: Alan R. Liss.
    • (1986) Free Radicals, Aging and Degenerative Diseases , pp. 51-74
    • Miquel, J.1    Fleming, J.E.2
  • 48
    • 0021329156 scopus 로고
    • A two-step hypothesis on the mechanism of in vitro cell aging: Cell differentiation followed by intrinsic mutagenesis
    • Miquel J., Fleming J.E. A two-step hypothesis on the mechanism of in vitro cell aging Cell differentiation followed by intrinsic mutagenesis . Exp Gerontol. 19:1984;31-36.
    • (1984) Exp Gerontol , vol.19 , pp. 31-36
    • Miquel, J.1    Fleming, J.E.2
  • 50
    • 0020459447 scopus 로고
    • Changes in mitochondrial DNA during aging
    • Murray M.A., Balcavage W.X. Changes in mitochondrial DNA during aging. Mech Ageing Dev. 20:1982;233-241.
    • (1982) Mech Ageing Dev , vol.20 , pp. 233-241
    • Murray, M.A.1    Balcavage, W.X.2
  • 51
    • 0021282458 scopus 로고
    • Structural and replicating forms of mitochondrial DNA in tissues from adult and senescent Balb/c mice and Fisher 344 rats
    • Piko L., Bulpitt K.J., Meyer R. Structural and replicating forms of mitochondrial DNA in tissues from adult and senescent Balb/c mice and Fisher 344 rats. Mech Ageing Dev. 26:1984;113-131.
    • (1984) Mech Ageing Dev , vol.26 , pp. 113-131
    • Piko, L.1    Bulpitt, K.J.2    Meyer, R.3
  • 52
    • 0029116061 scopus 로고
    • Oxidative damage to mitochondrial DNA and its relationship to ageing
    • Richter C. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int J Biochem Cell Biol. 27:1995;647-653.
    • (1995) Int J Biochem Cell Biol , vol.27 , pp. 647-653
    • Richter, C.1
  • 53
    • 0024266283 scopus 로고
    • Do mitochondrial DNA fragments promote cancer and aging?
    • Richter C. Do mitochondrial DNA fragments promote cancer and aging? FEBS Lett. 241:1988;1-5.
    • (1988) FEBS Lett , vol.241 , pp. 1-5
    • Richter, C.1
  • 54
    • 0027981624 scopus 로고
    • Thymus function, ageing and autoimmunity
    • Rose N.R. Thymus function, ageing and autoimmunity. Immunol Lett. 40:1994;225-230.
    • (1994) Immunol Lett , vol.40 , pp. 225-230
    • Rose, N.R.1
  • 55
    • 0025099535 scopus 로고
    • Lipid peroxidation and antioxidant supplementation in old age
    • Schafer L., Thorling E.B. Lipid peroxidation and antioxidant supplementation in old age. J Clin Lab Invest. 50:1990;69-75.
    • (1990) J Clin Lab Invest , vol.50 , pp. 69-75
    • Schafer, L.1    Thorling, E.B.2
  • 56
    • 0345176944 scopus 로고
    • In H. R. Warner, R. N. Butler, R. L. Sprott, E. L. Schneider (Eds.), Raven Press
    • Schneider, E. L. (1987). Theories of aging: a perspective. In H. R. Warner, R. N. Butler, R. L. Sprott, E. L. Schneider (Eds.), (pp. 1-4). Raven Press.
    • (1987) Theories of Aging: A Perspective , pp. 1-4
    • Schneider, E.L.1
  • 57
    • 0019406513 scopus 로고
    • Immunological studies in human ageing. II. Associated increase in anti-RNA and anti-DNA antibodies
    • Schuller E., Allinquant B., Reboul J., Fournier C., Dardenne M., Bach J.F. Immunological studies in human ageing. II. Associated increase in anti-RNA and anti-DNA antibodies. J Clin Lab Immunol. 6:1981;107-110.
    • (1981) J Clin Lab Immunol , vol.6 , pp. 107-110
    • Schuller, E.1    Allinquant, B.2    Reboul, J.3    Fournier, C.4    Dardenne, M.5    Bach, J.F.6
  • 58
    • 0344746736 scopus 로고
    • Urinary biomarkers of oxidative DNA base damage and human caloric intake
    • L. Fishbein. New York: Springer-Verlag
    • Simic M.G., Bergtold D.S. Urinary biomarkers of oxidative DNA base damage and human caloric intake. Fishbein L. Biological Effects of Dietary Restriction. 1991;217-225 Springer-Verlag, New York.
    • (1991) Biological Effects of Dietary Restriction , pp. 217-225
    • Simic, M.G.1    Bergtold, D.S.2
  • 60
    • 0025640126 scopus 로고
    • Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rats with special reference to parameters in two insect species
    • Sohal R.S., Arnold L.A., Sohal B.H. Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rats with special reference to parameters in two insect species. Free Radic Biol Med. 9:1990;495-500.
    • (1990) Free Radic Biol Med , vol.9 , pp. 495-500
    • Sohal, R.S.1    Arnold, L.A.2    Sohal, B.H.3
  • 61
    • 0031831270 scopus 로고    scopus 로고
    • Reactive oxygen-mediated protein oxidation in aging and disease
    • Stadtman E.R., Berlett B.S. Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab Rev. 30:1998;225-243.
    • (1998) Drug Metab Rev , vol.30 , pp. 225-243
    • Stadtman, E.R.1    Berlett, B.S.2
  • 62
    • 0018120561 scopus 로고
    • Quantitation of mitochondrial DNA and protein in the liver of Fisher 344 rats during aging
    • Stocco D.M., Hutson J.C. Quantitation of mitochondrial DNA and protein in the liver of Fisher 344 rats during aging. J Gerontol. 33:1978;802-810.
    • (1978) J Gerontol , vol.33 , pp. 802-810
    • Stocco, D.M.1    Hutson, J.C.2
  • 63
    • 0026021362 scopus 로고
    • Production of large amounts of hydrogen peroxide by human tumor cells
    • Szatrowski T.P., Nathan C.F. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51:1991;794-798.
    • (1991) Cancer Res , vol.51 , pp. 794-798
    • Szatrowski, T.P.1    Nathan, C.F.2
  • 64
    • 0025730060 scopus 로고
    • Hypothesis: The aging paradox and autoimmune disease
    • Talor E., Rose N.R. Hypothesis The aging paradox and autoimmune disease . Autoimmunity. 8:1991;245-249.
    • (1991) Autoimmunity , vol.8 , pp. 245-249
    • Talor, E.1    Rose, N.R.2
  • 66
    • 0023092149 scopus 로고
    • Prevention by vitamin E of experimental oral carcinogenesis
    • Trickler D., Shklar G. Prevention by vitamin E of experimental oral carcinogenesis. J Natl Cancer Inst. 78:1987;1615-1619.
    • (1987) J Natl Cancer Inst , vol.78 , pp. 1615-1619
    • Trickler, D.1    Shklar, G.2
  • 67
    • 0006144847 scopus 로고
    • Caloric restriction and its effects on molecular parameters especially DNA repair
    • L. Fishbein. New York: Springer Verlag
    • Turturro A., Hart R.W. Caloric restriction and its effects on molecular parameters especially DNA repair. Fishbein L. Biological Effects of Dietary Restriction. 1991;185-190 Springer Verlag, New York.
    • (1991) Biological Effects of Dietary Restriction , pp. 185-190
    • Turturro, A.1    Hart, R.W.2
  • 70
    • 2542505678 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial DNA mutations in human aging
    • Wei Y.H. Oxidative stress and mitochondrial DNA mutations in human aging. Proc Soc Exp Biol Med. 217:1998;53-63.
    • (1998) Proc Soc Exp Biol Med , vol.217 , pp. 53-63
    • Wei, Y.H.1
  • 72
    • 0028156003 scopus 로고
    • Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes
    • Weirich-Schwaiger H., Weirich H.G., Gruber B., Schweiger M., Hirsch-Kauffmann M. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutation Res. 316:1994;37-48.
    • (1994) Mutation Res , vol.316 , pp. 37-48
    • Weirich-Schwaiger, H.1    Weirich, H.G.2    Gruber, B.3    Schweiger, M.4    Hirsch-Kauffmann, M.5
  • 74
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer that nuclear DNA damage in human cells following oxidative stress
    • Yakes F.M., Van Houten B. Mitochondrial DNA damage is more extensive and persists longer that nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA. 94:1997;514-519.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2


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