Telomeres and their control

Annual Review of Genetics

Volumn 34, Issue , 2000, Pages 331-358

  McEachern, M J ^a   Krauskopf, A ^a   Blackburn, E H ^a  

^a Department of Genetics ^*  (United States)

Author keywords

Telomerase; Telomere proteins; Telomere regulation; Telomeric DNA; Telomeric recombination

Indexed keywords

CHROMOSOME PROTEIN; DNA;

DNA DETERMINATION; DNA PROTEIN COMPLEX; DNA RECOMBINATION; DNA REPLICATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVIEW; TELOMERE;

TELOMERASE; TELOMERE;

EID: 0034500453     PISSN: 00664197     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genet.34.1.331     Document Type: Review

References (178)

1. Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae
2. Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis
3. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
4. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae
5. A critical role for telomeres in suppressing and facilitating carcinogenesis
6. Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid
7. Identification of a telomere-binding activity from yeast
8. Growth of chromosome ends in multiplying trypanosomes
9. Telomeres and double-strand breaks: Trying to make ends meet
10. A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains
11. Chromosome ends in Drosophila without telomeric DNA sequences
12. Molecular characterization of the Anopheles gambiae 2L telomeric region via an integrated transgene
13. Progressive loss of DNA sequences from terminal chromosome deficiencies in Drosophila melanogaster
14. The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human
15. Structure and function of telomeres
16. Telomere states and cell fates
17. DNA termini in ciliate macronuclei
18. A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
19. Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in double strand break rejoining and in telomeric maintenance
20. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
21. Structure and polymorphism of human telomere-associated DNA
22. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
23. Telomere elongation in immortal human cells without detectable telomerase activity
24. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
25. Telomere dynamics and telomerase activity in in vitro immortalised human cells
26. Cloning and molecular characterization of a telomereic sequence from a temperature-induced Balbiani ring
27. CDC17: An essential gene that prevents telomere elongation in yeast
28. Secondary structure of vertebrate telomerase RNA
29. A human telomeric protein
30. Telomerase in yeast
31. Telomere-associated repeats in Chironomus form discrete subfamilies generated by gene conversion
32. Telomeric sequence diversity within the genus Saccharomyces
33. Telomere maintenance mechanisms and cellular immortalization
34. Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
35. Telomere transitions in yeast: The end of the chromosome as we know it
36. Regulation of telomere length and function by a Myb-domain protein in fission yeast
37. DNA end-joining: From yeast to man
38. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
39. A role for DNA-PK in retroviral DNA integration
40. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta
41. Est1 and Cdc13 as comediators of telomerase access
42. The RNA component of human telomerase
43. Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha
44. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
45. Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase
46. The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein
47. Altering specific telomerase RNA template residues affects active site function
48. Yeast Ku as a regulator of chromosomal DNA end structure
49. TEL1, a gene involved in controlling telomere length in S. cerevsiae, is homologous to the human ataxia telangiectasia gene
50. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
51. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
52. Mammalian telomeres end in a large duplex loop
53. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
54. A mammalian telomerase-associated protein
55. An overhanging 3′ terminus is a conserved feature of telomeres
56. Identification of autonomously replicating circular subtelomeric Y′ elements in Saccharomyces cerevisiae
57. Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA
58. Ku is associated with the telomere in mammals
59. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
60. Why do we have linear chromosomes? A matter of Adam and Eve
61. Isolation of telomeric DNA from the filamentous fungus Podospora anserina and construction of a self-replicating linear plasmid showing high transformation frequency
62. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
63. The case for epigenetic effects on centromere identity and function
64. Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by single P element insertional mutagenesis
65. Vaults and telomerase share a common subunit TEP1
66. Specific association of human telomerase activity with immortal cells and cancer
67. TIN2, a new regulator of telomere length in human cells
68. An unusual sequence arrangement in the telomeres of the germ-line micronucleus in Tetrahymena thermophila
69. Block in anaphase chromosome separation caused by a telomerase template mutation
70. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae
71. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus
72. Structure of the vault, a ubiquitous cellular component
73. The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA
74. Recognition of telomeric DNA
75. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
76. Rap1 protein regulates telomere turnover in yeast
77. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae
78. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase
79. Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres
80. Dynamics of telomere length variation in Tetrahymena thermophila
81. Isolation and functional analysis of a Kluyveromyces lactis RAP1 homologue
82. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
83. Identification of two RNA-binding proteins associated with human telomerase RNA
84. Viable deletions of a telomere from a Drosophila chromosome
85. Transposons in place of telomeric repeats at a Drosophila telomere
86. A novel mechanism for telomere size control in Saccharomyces cerevisiae
87. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity
88. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template
89. Reverse transcriptase motifs in the catalytic subunit of telomerase
90. Mutational analysis defines a C-terminal tail domain of RAP1 essential for telomeric silencing in Saccharomyces cerevisiae
91. Interspersed DNA element restricted to a specific group of telomeres in the dipteran Chironomus pallidivittatus
92. An alternative pathway for yeast telomere maintenance rescues est1-senescence
93. A mutant with a defect in telomere elongation leads to senescence in yeast
94. The kudos of non-homologous end-joining
95. Identification of yeast mutants with altered telomere structure
96. Cell cycle restriction of telomere elongation
97. A protein-counting mechanism for telomere length regulation in yeast
98. mu-2: Mutator gene in Drosophila that potentiates the induction of terminal deficiencies
99. A single telomerase RNA is sufficient for the synthesis of variable telomeric DNA repeats in ciliates of the genus Paramecium
100. A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts
101. Runaway telomere elongation caused by telomerase RNA gene mutations
102. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
103. Telomere fusions caused by mutating the terminal region of telomeric DNA
104. Unusually large telomeric repeats in the yeast Candida albicans
105. Telomerase activity in human renal cell carcinoma
106. Accelerated telomere shortening in ataxia telangiectasia
107. Sensorless checkpoint activation?
108. Stable integration and expression of a bacterial gene in the mosquito Anopheles gambiae
109. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
110. A telomerase component is defective in the human disease dyskeratosis congenita
111. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
112. Telomere dynamics in an immortal human cell line
113. Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops
114. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues
115. Two modes of survival of fission yeast without telomerase
116. Telomerase catalytic subunit homologs from fission yeast and human
117. TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family
118. Subrepeats result from regional DNA sequence conservation in tandem repeats in Chironomus telomeres
119. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
120. Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
121. The telomerase reverse transcriptase: Components and regulation
122. Telomeres, telomerase, and aging: Origin of the theory
123. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
124. Telomeres and telomerase: More than the end of the line
125. Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27
126. Terminal heterochromatin and alternative telomeric sequences in Allium cepa
127. Identification of a telomeric DNA sequence in Plasmodium berghei
128. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae
129. Functionally interacting telomerase RNAs in the yeast telomerase complex
130. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro
131. Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres
132. Chromosome ends: All the same under their caps
133. Cell cycle-dependent establishment of a late replication program
134. Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks
135. Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells
136. Telomeric repeats on small polydisperse circular DNA (spcDNA) and genomic instability
137. Characterization of Arabidopsis thaliana telomeres isolated in yeast
138. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae
139. Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts
140. A conserved secondary structure for telomerase RNA
141. Chromosome end elongation by recombination in the mosquito Anopheles gambiae
142. ATM: A mediator of multiple responses to genotoxic stress
143. Specific telomerase RNA residues distant from the template are essential for telomerase function
144. Longevity, stress response, and cancer in aging telomerase-deficient mice
145. Long tandem arrays of complex repeat units in Chironomus telomeres
146. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
147. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle
148. Generation of telomere-length heterogeneity in Saccharomyces cerevisiae
149. DNA sequences of telomeres maintained in yeast
150. Functional evidence for an RNA template in telomerase
151. Telomerase and telomere-binding proteins: Controlling the endgame
152. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements
153. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
154. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
155. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
156. Control of human telomere length by TRF1 and TRF2
157. Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: Isolation of viable mutants affecting both silencing and telomere length
158. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
159. Telomeretelomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
160. A spontaneously opened ring chromosome of Drosophila melanogaster has acquired He-T DNA sequences at both new telomeres
161. Template boundary in a yeast telomerase specified by RNA structure
162. HeT DNA: A family of mosaic repeated sequences specific for heterochromatin in Drosophila melanogaster
163. TRF2 protects human telomeres from end-to-end fusions
164. Telomere processing in Euplotes
165. Est1 has the properties of a single-stranded telomere end-binding protein
166. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
167. Three telomerases with completely non-telomeric template replacements are catalytically active
168. Origin of concatemeric T7 DNA
169. Telomeres: Moonlighting by DNA repair proteins
170. Evidence for a new step in telomere maintenance
171. Origin activation and formation of single-strand TG1-3 tails occur sequentially in late S phase on a yeast linear plasmid
172. INK4 and telomerase in immortalization of human cells
173. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
174. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
175. Structure and function of telomeres
176. Efficient and dispersed local P element transposition from Drosophila females
177. Telomerase extends the life-span of virus-transformed human cells without net telomere lengthening