Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae

Molecular and Cellular Biology

Volumn 16, Issue 9, 1996, Pages 4614-4620

  Adams, Aegina K ^a   Holm, Connie ^a  

^a San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; FUNGAL DNA;

ARTICLE; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTER; FUNGAL GENETICS; FUNGUS MUTANT; GENE MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STRAIN DIFFERENCE; STRUCTURAL GENE; TELOMERE;

FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0029772312     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.9.4614     Document Type: Article

References (47)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1988. Current protocols in molecular biology. Greene Publishing Associates and Wiley Interscience, New York.
2. Blackburn, E. H. 1984. The molecular structure of centromeres and telomeres. Annu. Rev. Biochem. 53:163-194.
3. Blackburn, E. H. 1991. Structure and function of telomeres. Nature (London) 350:569-573.
4. Blasco, M. A., W. Funk, B. Villeponteau, and C. W. Greider. 1995. Functional characterization and developmental regulation of mouse telomerase RNA. Science 269:1267-1270.
5. Broccoli, D., J. W. Young, and T. deLange. 1995. Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA 92: 9082-9086.
6. Buchman, A. R., N. F. Lue, and R. D. Kornberg. 1988. Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein. Mol. Cell. Biol. 8:5086-5099.
7. Budd, M. E., K. D. Wittrup, J. E. Bailey, and J. L. Campbell. 1989. DNA polymerase I is required for premeiotic DNA replication and sporulation but not for X-ray repair in Saccharomyces cerevisiae. Mol. Cell. Biol. 9:365-376.
8. Campbell, J. L., and C. S. Newlon. 1991. Chromosomal DNA replication, p. 41-146. In J. R. Broach, J. R. Pringle, and E. W. Jones (ed.). The molecular and cellular biology of the yeast Saccharomyces: genome dynamics, protein synthesis, and energetics, vol. 1. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
9. Carson, M. J., and L. Hartwell. 1985. CDC17: an essential gene that prevents telomere elongation in yeast. Cell 42:249-257.
10. Chan, C. S., and B.-K. Tye. 1983. Organization of DNA sequences and replication origins at yeast telomeres. Cell 33:563-573.
11. Cockell, M., F. Palladino, T. Laroche, G. Kyrion, C. Liu, A. J. Lustig, and S. M. Gasser. 1995. The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J. Cell Biol. 129:909-924.
12. Conn, M., and E. H. Blackburn. 1995. Telomerase in yeast. Science 269: 396-400.
13. Conrad, M. N., J. H. Wright, A. J. Wolf, and V. A. Zakian. 1990. RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell 63:739-750.
14. deLange, T., L. Shiue, R. M. Myers, D. R. Cox, S. L. Naylor, A. M. Killerj, and H. E. Varmus. 1990. Structure and variability of human chromosome ends. Mol. Cell. Biol. 10:518-527.
15. Feng, J., W. D. Funk, S.-S. Wang, S. L. Weinrich, A. A. Avilion, C.-P. Chiu, R. R. Adams, E. Chang, R. C. Allsopp, J. Yu, S. Le, M. D. West, C. B. Harley, W. H. Andrews, C. W. Greider, and B. Villeponteau. 1995. The RNA component of human telomerase. Science 269:1236-1241.
16. Gottschling, D. E., and V. A. Zakian. 1986. Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA. Cell 47:195-205.
17. Greider, C. W. Telomere length regulation. Annu. Rev. Biochem., in press.
18. Greider, C. W., and E. H. Blackburn. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature (London) 337:331-337.
19. Harley, C. B., A. B. Futcher, and C. W. Greider. 1990. Telomeres shorten during ageing of human fibroblasts. Nature (London) 345:458-460.
20. Hartwell, L. H. 1978. Cell division from a genetic perspective. J. Cell Biol. 77:627-637.
21. Hartwell, L. H., R. K. Mortimer, J. Culotti, and M. Culotti. 1973. Genetic control of the cell division cycle in yeast. V. Genetic analysis of cdc mutants. Genetics 74:267-286.
22. Hastie, N. D., M. Dempster, M. G. Dunlop, A. M. Thompson, D. K. Green, and R. C. Allshire. 1990. Telomere reduction in human colorectal carcinoma and with ageing. Nature (London) 346:866-868.
23. Howell, E. A., M. A. McAlear, D. Rose, and C. Holm. 1994. CDC44: a putative nucleotide-binding protein required for cell cycle progression that has homology to subunits of replication factor C. Mol. Cell. Biol. 14:255-267.
24. Hutter, K.-J., and H. E. Eipel. 1979. Microbial determinations by flow cytometry. J. Gen. Microbiol. 113:367-375.
25. Johnston, L. H., and A. P. Thomas. 1982. The isolation of new DNA synthesis mutants in the yeast Saccharomyces cerevisiae. Mol. Gen. Genet. 186:439-444.
26. Lin, J.-J., and V. A. Zakian. 1995. An in vitro assay for Saccharomyces telomerase requires EST1. Cell 81:1127-1135.
27. Lingner, J., J. P. Cooper, and T. R. Cech. 1995. Telomerase and DNA end replication: no longer a lagging strand problem? Science 269:1533-1534.
28. Longtine, M. S., N. M. Wilson, M. E. Petracek, and J. Berman. 1989. A yeast telomere binding activity binds to two related telomere sequence motifs and is indistinguishable from RAP1. Curr. Genet. 16:225-239.
29. Lundblad, V., and J. W. Szostak. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633-643.
30. McAlear, M. A., E. A. Howell, K. K. Espenshade, and C. Holm. 1994. Proliferating-cell nuclear antigen (pol30) mutations suppress cdc44 mutations and identify potential regions of interaction between the two encoded proteins. Mol. Cell. Biol. 14:4390-4397.
31. McEachern, M. J., and E. H. Blackburn. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature (London) 376:403-409.
32. Palladino, F., T. Laroche, E. Gilson, A. Axelrod, L. Pillus, and S. M. Gasser. 1993. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell 75:543-555.
33. Price, C. M. 1990. Telomere structure in Euplotes crassus: characterization of DNA-protein interactions and isolation of a telomere-binding protein. Mol. Cell. Biol. 10:3421-3431.
34. Rose, M., P. Hieter, and F. Winston. 1990. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
35. Runge, K. W., and V. A. Zakian. 1989. Introduction of extra telomeric DNA sequences into Saccharomyces cerevisiae results in telomere elongation. Mol. Cell. Biol. 9:1488-1497.
36. Shampay, J., and E. H. Blackburn. 1988. Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 85: 534-538.
37. Sherman, F., G. R. Fink, and J. B. Hicks. 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
38. Shore, D., and K. Nasmyth. 1987. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 51:721-732.
39. Singer, M. S., and D. E. Gottschling. 1994. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266:404-409.
40. Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503-517.
41. Szostak, J. W., and E. H. Blackburn. 1982. Cloning yeast telomeres on linear plasmid vectors. Cell 29:245-255.
42. Tsurimoto, T., and B. Stillman. 1991. Replication factors required for SV40 DNA replication in vitro. I. DNA structure-specific recognition of a primer-template junction by eukaryotic DNA polymerases and their accessory proteins. J. Biol. Chem. 266:1950-1960.
43. Tsurimoto, T., and B. Stillman. 1991. Replication factors required for SV40 DNA replication in vitro. II. Switching of DNA polymerase α and δ during initiation of leading and lagging strands. J. Biol. Chem. 266:1961-1968.
44. Waga, S., and B. Stillman. 1994. Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro. Nature (London) 369:207-212.
45. Walmsley, R. M., and T. D. Petes. 1985. Genetic control of chromosome length in yeast. Proc. Natl. Acad. Sci. USA 82:506-510.
46. Watson, J. D. 1972. Origin of concatemeric T7 DNA. Nat. New Biol. 239: 197-201.
47. Zakian, V. A. 1989. Structure and function of telomeres. Annu. Rev. Genet. 23:579-604.