메뉴 건너뛰기




Volumn 11, Issue 4, 1997, Pages 528-540

Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro

Author keywords

nonprocessivity; S. cerevisiae; telomerase; telomerase RNA

Indexed keywords

RNA DIRECTED DNA POLYMERASE; TELOMERASE;

EID: 0031029377     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.4.528     Document Type: Article
Times cited : (136)

References (49)
  • 1
    • 0029128539 scopus 로고
    • Boundary elements of the Tetrahymena telomerase RNA template and alignment domains
    • Autexier, C. and C.W. Greider. 1995. Boundary elements of the Tetrahymena telomerase RNA template and alignment domains. Genes & Dev. 9: 2227-2239.
    • (1995) Genes & Dev. , vol.9 , pp. 2227-2239
    • Autexier, C.1    Greider, C.W.2
  • 2
    • 0028305614 scopus 로고
    • Telomeres-No end in sight
    • Blackburn, E.H. 1994. Telomeres-No end in sight. Cell 77: 621-623.
    • (1994) Cell , vol.77 , pp. 621-623
    • Blackburn, E.H.1
  • 3
    • 0029154735 scopus 로고
    • Functional characterization and developmental regulation of mouse telomerase RNA
    • Blasco, M.A., W. Funk, B. Villeponteau, and C.W. Greider. 1995a. Functional characterization and developmental regulation of mouse telomerase RNA. Science 269: 1267-1270.
    • (1995) Science , vol.269 , pp. 1267-1270
    • Blasco, M.A.1    Funk, W.2    Villeponteau, B.3    Greider, C.W.4
  • 4
    • 0030070054 scopus 로고
    • Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
    • Blasco, M.A., M. Rizen, C.W. Greider, and D. Hanahan. 1995b. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nature Genet. 12: 200-204.
    • (1995) Nature Genet. , vol.12 , pp. 200-204
    • Blasco, M.A.1    Rizen, M.2    Greider, C.W.3    Hanahan, D.4
  • 7
    • 0029155795 scopus 로고
    • Telomerase in yeast
    • Cohn, M. and E.H. Blackburn. 1995. Telomerase in yeast. Science 269: 396-400.
    • (1995) Science , vol.269 , pp. 396-400
    • Cohn, M.1    Blackburn, E.H.2
  • 8
    • 0027275438 scopus 로고
    • Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation
    • Collins, K. and C.W. Greider. 1993. Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes & Dev. 7: 1364-1376.
    • (1993) Genes & Dev. , vol.7 , pp. 1364-1376
    • Collins, K.1    Greider, C.W.2
  • 9
    • 0000369119 scopus 로고
    • Cytology of telomeres
    • (ed. E. Blackburn and C. Greider), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Dernburg, A.F., J.W. Sedat, W.Z. Cande, and H.W. Bass. 1995. Cytology of telomeres. In Telomeres (ed. E. Blackburn and C. Greider), pp. 295-338. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1995) Telomeres , pp. 295-338
    • Dernburg, A.F.1    Sedat, J.W.2    Cande, W.Z.3    Bass, H.W.4
  • 11
    • 0029655261 scopus 로고    scopus 로고
    • Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase
    • Gilley, D. and E.H. Blackburn. 1996. Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase. Mol. Cell. Biol. 16: 66-75.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 66-75
    • Gilley, D.1    Blackburn, E.H.2
  • 12
    • 0029144984 scopus 로고
    • Altering specific telomerase RNA template residues affects active site function
    • Gilley, D., M.S. Lee, and E.H. Blackburn. 1995. Altering specific telomerase RNA template residues affects active site function. Genes & Dev. 9: 2214-2226.
    • (1995) Genes & Dev. , vol.9 , pp. 2214-2226
    • Gilley, D.1    Lee, M.S.2    Blackburn, E.H.3
  • 13
    • 0029894237 scopus 로고    scopus 로고
    • Telomere length regulation
    • Greider, C.W. 1996. Telomere length regulation. Annu. Rev. Biochem. 65: 337-365.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 337-365
    • Greider, C.W.1
  • 14
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider, C.W. and E.H. Blackburn. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 15
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • _. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331-337.
    • (1989) Nature , vol.337 , pp. 331-337
  • 16
    • 0024573115 scopus 로고
    • An overhanging 3′ terminus is a conserved feature of telomeres
    • Henderson, E.R. and E.H. Blackburn. 1989. An overhanging 3′ terminus is a conserved feature of telomeres. Mol. Cell. Biol. 9: 345-348.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 345-348
    • Henderson, E.R.1    Blackburn, E.H.2
  • 17
    • 0024520745 scopus 로고
    • Site-directed mutagenesis by overlap extension using the polymerase chain reaction
    • Ho, S.N., H.D. Hunt, R.M. Horton, J.K. Pullen, and L.R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77: 51-59.
    • (1989) Gene , vol.77 , pp. 51-59
    • Ho, S.N.1    Hunt, H.D.2    Horton, R.M.3    Pullen, J.K.4    Pease, L.R.5
  • 18
    • 0025974219 scopus 로고
    • Tackling the protease problem in Saccharomyces cerevisiae
    • Jones, E. 1991. Tackling the protease problem in Saccharomyces cerevisiae. Methods Enzymol. 194: 428-453.
    • (1991) Methods Enzymol. , vol.194 , pp. 428-453
    • Jones, E.1
  • 19
    • 0019568388 scopus 로고
    • All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus
    • Klobutcher, L.A., M.T. Swanton, P. Donini, and D.M. Prescott. 1981. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus. Proc. Natl. Acad. Sci. 78: 3015-3019.
    • (1981) Proc. Natl. Acad. Sci. , vol.78 , pp. 3015-3019
    • Klobutcher, L.A.1    Swanton, M.T.2    Donini, P.3    Prescott, D.M.4
  • 20
    • 0028484771 scopus 로고
    • Telomeres lead chromosome movement
    • Kohli, J. 1994. Telomeres lead chromosome movement. Curr. Biol. 4: 724-727.
    • (1994) Curr. Biol. , vol.4 , pp. 724-727
    • Kohli, J.1
  • 22
    • 0029743764 scopus 로고    scopus 로고
    • Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
    • Krauskopf, A. and E.H. Blackburn. 1996. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383: 354-357.
    • (1996) Nature , vol.383 , pp. 354-357
    • Krauskopf, A.1    Blackburn, E.H.2
  • 23
    • 0029033695 scopus 로고
    • An in vitro assay for Saccharomyces telomerase requires EST-1
    • Lin, J.-J. and V.A. Zakian. 1995. An in vitro assay for Saccharomyces telomerase requires EST-1. Cell 81: 1127-1135.
    • (1995) Cell , vol.81 , pp. 1127-1135
    • Lin, J.-J.1    Zakian, V.A.2
  • 24
    • 0028106199 scopus 로고
    • Telomerase RNAs of different ciliates have a common secondary structure and a permuted template
    • Lingner, J., L.L. Hendrick, and T.R. Cech. 1994. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes & Dev. 8: 1984-1998.
    • (1994) Genes & Dev. , vol.8 , pp. 1984-1998
    • Lingner, J.1    Hendrick, L.L.2    Cech, T.R.3
  • 25
    • 0029143921 scopus 로고
    • ATP-dependent processivity of a telomerase activity from Saccharomyces cerevisiae
    • Lue, N.P. and J.C. Wang. 1995. ATP-dependent processivity of a telomerase activity from Saccharomyces cerevisiae. J. Biol. Chem. 270: 21453-21456.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21453-21456
    • Lue, N.P.1    Wang, J.C.2
  • 26
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • Lundblad, V. and J.W. Szostak. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57: 633-643.
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 27
    • 0027266758 scopus 로고
    • An alternative pathway for yeast telomere maintenance rescues est1- Senescence
    • Lindblad, V. and E.H. Blackburn. 1993. An alternative pathway for yeast telomere maintenance rescues est1-senescence. Cell 73: 347-360.
    • (1993) Cell , vol.73 , pp. 347-360
    • Lindblad, V.1    Blackburn, E.H.2
  • 28
    • 0026719774 scopus 로고
    • Hoogsteen G-G base pairing is dispensable for telomere healing in yeast
    • Lustig, A.J. 1992. Hoogsteen G-G base pairing is dispensable for telomere healing in yeast. Nucleic Acids Res. 20: 3021-3028.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 3021-3028
    • Lustig, A.J.1
  • 29
    • 0028264813 scopus 로고
    • A conserved sequence motif within the exceptionally diverse telomeric sequenced of budding yeasts
    • McEachern, M.J. and E.H. Blackburn. 1994. A conserved sequence motif within the exceptionally diverse telomeric sequenced of budding yeasts. Proc. Natl. Acad. Sci. 91: 3453-3457.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 3453-3457
    • McEachern, M.J.1    Blackburn, E.H.2
  • 30
    • 0029102354 scopus 로고
    • Runaway telomere elongation caused by telomerase RNA gene mutations
    • _. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376: 403-409.
    • (1995) Nature , vol.376 , pp. 403-409
  • 31
    • 0029895352 scopus 로고    scopus 로고
    • Processing of nontelomeric 3′ ends by telomerase: Default template alignment and endonucleolytic cleavage
    • Melek, M., E.C. Greene, and D.E. Shippen. 1996. Processing of nontelomeric 3′ ends by telomerase: Default template alignment and endonucleolytic cleavage. Mol Cell. Biol. 16: 3437-3445.
    • (1996) Mol Cell. Biol. , vol.16 , pp. 3437-3445
    • Melek, M.1    Greene, E.C.2    Shippen, D.E.3
  • 32
    • 0029845892 scopus 로고    scopus 로고
    • Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
    • Nugent, C.I., T.R. Hughes, N.F. Lue, and V.I. Lundblad. 1996. Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274: 249-252.
    • (1996) Science , vol.274 , pp. 249-252
    • Nugent, C.I.1    Hughes, T.R.2    Lue, N.F.3    Lundblad, V.I.4
  • 33
    • 0015844590 scopus 로고
    • A theory of marginotomy
    • Olovnikov, A.M. 1973. A theory of marginotomy. J. Theor. Biol. 41: 181-190.
    • (1973) J. Theor. Biol. , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 34
    • 0029040101 scopus 로고
    • Developmental and tissue specific regulation of mouse telomerase and telomere length
    • Prowse, K.R. and C.W. Greider. 1995. Developmental and tissue specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci.92: 4818-4822.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 35
    • 0027467847 scopus 로고
    • Identification of a nonprocessive telomerase activity from mouse cells
    • Prowse, K.R., A.A. Avilion, and C.W. Greider. 1993. Identification of a nonprocessive telomerase activity from mouse cells. Proc. Natl. Acad. Sci. 90: 1493-1497.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 1493-1497
    • Prowse, K.R.1    Avilion, A.A.2    Greider, C.W.3
  • 36
    • 0025944831 scopus 로고
    • A conserved secondary structure for telomerase RNA
    • Romero, D. and E.H. Blackburn. 1991. A conserved secondary structure for telomerase RNA. Cell 67: 343-353.
    • (1991) Cell , vol.67 , pp. 343-353
    • Romero, D.1    Blackburn, E.H.2
  • 37
    • 0025979877 scopus 로고
    • Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast
    • Rothstein, R. 1991. Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast. Methods Enzymol. 194: 281-301.
    • (1991) Methods Enzymol. , vol.194 , pp. 281-301
    • Rothstein, R.1
  • 39
    • 0023742169 scopus 로고
    • Generation of telomerelength heterogeneity in Saccharomyces cerevisiae
    • Shampay, J. and E.H. Blackburn. 1988. Generation of telomerelength heterogeneity in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 85: 534-538.
    • (1988) Proc. Natl. Acad. Sci. , vol.85 , pp. 534-538
    • Shampay, J.1    Blackburn, E.H.2
  • 40
    • 0021234973 scopus 로고
    • DNA sequences of telomeres maintained in yeast
    • Shampay, J., J.W. Szostak, and E.H. Blackburn. 1984. DNA sequences of telomeres maintained in yeast. Nature 310: 154-157.
    • (1984) Nature , vol.310 , pp. 154-157
    • Shampay, J.1    Szostak, J.W.2    Blackburn, E.H.3
  • 41
    • 0024669291 scopus 로고
    • A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
    • Sikorski, R.S. and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
    • (1989) Genetics , vol.122 , pp. 19-27
    • Sikorski, R.S.1    Hieter, P.2
  • 42
    • 0027944347 scopus 로고
    • TLC1- Template RNA component of Saccharomyces cerevisiae telomerase
    • Singer, M.S. and D.E. Gottschling. 1994. TLC1-Template RNA component of Saccharomyces cerevisiae telomerase. Science 266: 404-409.
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 43
    • 0029883887 scopus 로고    scopus 로고
    • Association of the Est1 protein with telomerase activity in yeast
    • Steiner, B.R., K. Hidaka, and B. Futcher. 1996. Association of the Est1 protein with telomerase activity in yeast. Proc. Natl. Acad. Sci. 93: 2817-2821.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 2817-2821
    • Steiner, B.R.1    Hidaka, K.2    Futcher, B.3
  • 44
    • 0019949718 scopus 로고
    • Cloning yeast telomeres on linear plasmid vectors
    • Szostak, J.W. and E.H. Blackburn. 1982. Cloning yeast telomeres on linear plasmid vectors. Cell 29: 245-255.
    • (1982) Cell , vol.29 , pp. 245-255
    • Szostak, J.W.1    Blackburn, E.H.2
  • 45
    • 0015515155 scopus 로고
    • Origin of concatameric T7 DNA
    • Watson, J.D. 1972. Origin of concatameric T7 DNA. Nature New Biol. 239: 197-201.
    • (1972) Nature New Biol. , vol.239 , pp. 197-201
    • Watson, J.D.1
  • 47
    • 0026037255 scopus 로고
    • Developmentally programmed healing of chromosomes by telomerase in Tetrahymena
    • Yu, G.-L. and E.H. Blackburn. 1991. Developmentally programmed healing of chromosomes by telomerase in Tetrahymena. Cell 67: 823-832.
    • (1991) Cell , vol.67 , pp. 823-832
    • Yu, G.-L.1    Blackburn, E.H.2
  • 48
    • 0025279059 scopus 로고
    • In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
    • Yu, G.-L., J.D. Bradley, L.D. Attardi, and E.H. Blackburn. 1990. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344: 126-132.
    • (1990) Nature , vol.344 , pp. 126-132
    • Yu, G.-L.1    Bradley, J.D.2    Attardi, L.D.3    Blackburn, E.H.4
  • 49
    • 0029563009 scopus 로고
    • Telomeres: Beginning to understand the end
    • Zakian, V. A. 1995. Telomeres: Beginning to understand the end. Science 270: 1601-1607.
    • (1995) Science , vol.270 , pp. 1601-1607
    • Zakian, V.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.