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Greider CW. Telomere length regulation. Annu Rev Biochem. 65:1996;337-365.
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Biessmann, H.1
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Lundblad V, Wright WE. Telomeres and telomerase: a simple picture becomes complex. Cell. 87:1996;369-375.
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Lundblad, V.1
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The DNA structures at the ends of eukaryotic chromosomes
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Wellinger RJ, Sen D. The DNA structures at the ends of eukaryotic chromosomes. Eur J Cancer. 33:1997;735-749.
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Zakian VA. Structure, function, and replication of Saccharomyces cerevisiae telomeres. Annu Rev Genet. 30:1996;141-172.
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Zakian, V.A.1
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Louis EJ. The chromosome ends of Saccharomyces cerevisiae. Yeast. 11:1995;1553-1573.
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Yeast
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Louis, E.J.1
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7
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0028872918
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The proterminal regions and telomeres of human chromosomes
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Royle NJ. The proterminal regions and telomeres of human chromosomes. Adv Genet. 32:1995;273-315.
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Adv Genet
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Royle, N.J.1
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8
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0031029805
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The relationship between chromosome structure and function at a human telomeric region
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of special interest. A detailed structural and functional analysis of the distal-most 285kb of sequence from human chromosome 16p is presented. Telomeric and subtelomeric sequences are described, providing a structural prototype for other human chromosomes.
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Flint J, Thomas K, Micklem G, Raynham H, Clark K, Doggett NA, King A, Higgs DR. The relationship between chromosome structure and function at a human telomeric region. of special interest Nat Genet. 15:1997;252-257 A detailed structural and functional analysis of the distal-most 285kb of sequence from human chromosome 16p is presented. Telomeric and subtelomeric sequences are described, providing a structural prototype for other human chromosomes.
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Nat Genet
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Flint, J.1
Thomas, K.2
Micklem, G.3
Raynham, H.4
Clark, K.5
Doggett, N.A.6
King, A.7
Higgs, D.R.8
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9
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0030762352
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Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains
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of outstanding interest. The authors have sequenced and compared DNA from the ends of three human chromosomes in a search for conserved sequences within the subtelomeric regions. The analysis reveals a striking similarity to the sequence organisation found at the ends of yeast chromosomes.
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Flint J, Bates GP, Clark K, Dorman A, Willingham D, Roe BA, Micklem G, Higgs DR, Louis EJ. Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains. of outstanding interest Hum Mol Genet. 6:1997;1305-1314 The authors have sequenced and compared DNA from the ends of three human chromosomes in a search for conserved sequences within the subtelomeric regions. The analysis reveals a striking similarity to the sequence organisation found at the ends of yeast chromosomes.
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(1997)
Hum Mol Genet
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, pp. 1305-1314
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Flint, J.1
Bates, G.P.2
Clark, K.3
Dorman, A.4
Willingham, D.5
Roe, B.A.6
Micklem, G.7
Higgs, D.R.8
Louis, E.J.9
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10
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0028988486
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ST-1, a 39-kilodalton protein in Trypanosoma brucei, exhibits a dual affinity for the duplex form of the 29-base-pair subtelomeric repeat and its C-rich strand
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Eid JE, Sollnerwebb B. ST-1, a 39-kilodalton protein in Trypanosoma brucei, exhibits a dual affinity for the duplex form of the 29-base-pair subtelomeric repeat and its C-rich strand. Mol Cell Biol. 15:1995;389-397.
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Mol Cell Biol
, vol.15
, pp. 389-397
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Eid, J.E.1
Sollnerwebb, B.2
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11
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0002297374
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The expression sites for variant surface glycoproteins of Trypanosoma brucei
-
of special interest. G. Hide, J.C. Mottram, G.H. Coombs, Holmes P.H. CAB International Wallingford This chapter comprehensively covers the topic of VSG expression including VSG switching, control of expression sites and DNA modification.
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Borst P, Bitter W, Blundell P, Cross M, McCulloch R, Rudenko G, Taylor MC, van Leeuwen F. The expression sites for variant surface glycoproteins of Trypanosoma brucei. of special interest Hide G, Mottram JC, Coombs GH, Holmes PH. Trypanosomiasis and Leishmaniasis. 1997;109-131 CAB International, Wallingford, This chapter comprehensively covers the topic of VSG expression including VSG switching, control of expression sites and DNA modification.
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(1997)
Trypanosomiasis and Leishmaniasis
, pp. 109-131
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-
Borst, P.1
Bitter, W.2
Blundell, P.3
Cross, M.4
McCulloch, R.5
Rudenko, G.6
Taylor, M.C.7
Van Leeuwen, F.8
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12
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0028899139
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Structure and superstructure of Plasmodium falciparum subtelomeric regions
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Pace T, Ponzi M, Scotti R, Frontali C. Structure and superstructure of Plasmodium falciparum subtelomeric regions. Mol Biochem Parasitol. 69:1995;257-268.
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Mol Biochem Parasitol
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Pace, T.1
Ponzi, M.2
Scotti, R.3
Frontali, C.4
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13
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0029739905
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The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes
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of special interest. The authors have constructed a YAC contig of chromosome 12 from P. falciparum and show that the var genes are arranged in clusters, two of which are in the repetitive subtelomeric sequences. Analysis suggests that recombination has occurred between the ends of heterologous chromosomes, raising important implications for the generation of diversity in the var gene family and, therefore, antigenic variation.
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Rubio JP, Thompson JK, Cowman AF. The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes. of special interest EMBO J. 15:1996;4069-4077 The authors have constructed a YAC contig of chromosome 12 from P. falciparum and show that the var genes are arranged in clusters, two of which are in the repetitive subtelomeric sequences. Analysis suggests that recombination has occurred between the ends of heterologous chromosomes, raising important implications for the generation of diversity in the var gene family and, therefore, antigenic variation.
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(1996)
EMBO J
, vol.15
, pp. 4069-4077
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Rubio, J.P.1
Thompson, J.K.2
Cowman, A.F.3
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14
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0030845471
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The chromosomal organisation of the Plasmodium falciparum var gene family is conserved
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Thompson JK, Rubio JP, Caruana S, Brockman A, Wickham E, Cowman AF. The chromosomal organisation of the Plasmodium falciparum var gene family is conserved. Mol Biochem Parasitol. 87:1997;49-60.
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(1997)
Mol Biochem Parasitol
, vol.87
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Thompson, J.K.1
Rubio, J.P.2
Caruana, S.3
Brockman, A.4
Wickham, E.5
Cowman, A.F.6
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15
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0030027770
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Translocation of surface antigen genes to a unique telomeric expression site in Pneumocystis carinii
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Sunkin SM, Stringer JR. Translocation of surface antigen genes to a unique telomeric expression site in Pneumocystis carinii. Mol Microbiol. 19:1996;283-295.
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Mol Microbiol
, vol.19
, pp. 283-295
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Sunkin, S.M.1
Stringer, J.R.2
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16
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0030033311
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Pneumocystis carinii telomere repeats are composed of TTAGGG and the subtelomeric sequence contains a gene encoding the major surface glycoprotein
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Underwood AP, Louis EJ, Borts RH, Stringer JR, Wakefield AE. Pneumocystis carinii telomere repeats are composed of TTAGGG and the subtelomeric sequence contains a gene encoding the major surface glycoprotein. Mol Microbiol. 19:1996;273-281.
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Mol Microbiol
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, pp. 273-281
-
-
Underwood, A.P.1
Louis, E.J.2
Borts, R.H.3
Stringer, J.R.4
Wakefield, A.E.5
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17
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0030606496
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Unique telomeric expression site of major-surface-glycoprotein genes of Pneumocystis carinii
-
of special interest. This study provides the first genetic evidence for homologous recombination within the MSG coding sequences. The authors demonstrate that the UCS expression site of MSG genes is subtelomeric and comparison of UCS clones indicates that all clones originate from a single expression site. A recombination model for translocation of MSG genes is proposed. See also [15, 16]
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Wada M, Nakamura Y. Unique telomeric expression site of major-surface-glycoprotein genes of Pneumocystis carinii. of special interest DNA Research. 3:1996;55-64 This study provides the first genetic evidence for homologous recombination within the MSG coding sequences. The authors demonstrate that the UCS expression site of MSG genes is subtelomeric and comparison of UCS clones indicates that all clones originate from a single expression site. A recombination model for translocation of MSG genes is proposed. See also [15, 16].
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(1996)
DNA Research
, vol.3
, pp. 55-64
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Wada, M.1
Nakamura, Y.2
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18
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0028938253
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Parasitism and chromosome dynamics in protozoan parasites: Is there a connection?
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Lanzer M, Fischer K, Le Blancq SM. Parasitism and chromosome dynamics in protozoan parasites: is there a connection? Mol Biochem Parasitol. 70:1995;1-8.
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Mol Biochem Parasitol
, vol.70
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Lanzer, M.1
Fischer, K.2
Le Blancq, S.M.3
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19
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0028959218
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The unusual telomeres of Drosophila
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Mason JM, Biessmann H. The unusual telomeres of Drosophila. Trends Genet. 11:1995;58-62.
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(1995)
Trends Genet
, vol.11
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Mason, J.M.1
Biessmann, H.2
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20
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0030033715
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Drosophila telomeres: New views on chromosome evolution
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Pardue ML, Danilevskaya ON, Lowenhaupt K, Slot F, Traverse KL. Drosophila telomeres: new views on chromosome evolution. Trends Genet. 12:1996;48-52.
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Trends Genet
, vol.12
, pp. 48-52
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Pardue, M.L.1
Danilevskaya, O.N.2
Lowenhaupt, K.3
Slot, F.4
Traverse, K.L.5
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22
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0029980065
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Terminal long tandem repeats in chromosomes from Chironomus pallidivittatus
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in press
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Lopez CC, Nielsen L, Edstrom JE. Terminal long tandem repeats in chromosomes from Chironomus pallidivittatus. Mol Cell Biol. 16:1996;3285-3290. in press.
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Mol Cell Biol
, vol.16
, pp. 3285-3290
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Lopez, C.C.1
Nielsen, L.2
Edstrom, J.E.3
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23
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0030879327
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A new family of site-specific retrotransposons, SART1, is inserted into telomeric repeats of the silkworm, Bombyx mori
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Takahashi H, Okazaki S, Fujiwara H. A new family of site-specific retrotransposons, SART1, is inserted into telomeric repeats of the silkworm, Bombyx mori. Nucleic Acids Res. 25:1997;1578-1584.
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Nucleic Acids Res
, vol.25
, pp. 1578-1584
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Takahashi, H.1
Okazaki, S.2
Fujiwara, H.3
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24
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0029069498
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Structural analysis of TRAS1, a novel family of telomeric repeat-associated retrotransposons in the silkworm, Bombyx mori
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Okazaki S, Ishikawa H, Fujiwara H. Structural analysis of TRAS1, a novel family of telomeric repeat-associated retrotransposons in the silkworm, Bombyx mori. Mol Cell Biol. 15:1995;4545-4552.
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Mol Cell Biol
, vol.15
, pp. 4545-4552
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Okazaki, S.1
Ishikawa, H.2
Fujiwara, H.3
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25
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0026447021
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Genetic mapping of tandemly repeated telomeric DNA sequences in tomato (Lycopersicon esculentum)
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Ganal MW, Broun P, Tanksley SD. Genetic mapping of tandemly repeated telomeric DNA sequences in tomato (Lycopersicon esculentum). Genomics. 14:1992;444-448.
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Genomics
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Ganal, M.W.1
Broun, P.2
Tanksley, S.D.3
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26
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0028928123
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The telomeric sequence is directly attached to the HRS60 subtelomeric tandem repeat in tobacco chromosomes
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Fajkus J, Kralovics R, Kovarik A, Fajkusova L. The telomeric sequence is directly attached to the HRS60 subtelomeric tandem repeat in tobacco chromosomes. FEBS Lett. 364:1995;33-35.
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FEBS Lett
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Fajkus, J.1
Kralovics, R.2
Kovarik, A.3
Fajkusova, L.4
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27
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0029893390
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How do Alliaceae stabilize their chromosome ends in the absence of TTTAGGG sequences
-
of special interest. Some types of Allium species are the only example of plants that do not possess the simple telomere repeat sequences. Highly repetitive satellite and/or rDNA sequences are identified at the chromosome termini, suggesting that the ends are maintained by homologous recombination between repeats.
-
Pich U, Fuchs J, Schubert I. How do Alliaceae stabilize their chromosome ends in the absence of TTTAGGG sequences. of special interest Chromosome Res. 4:1996;207-213 Some types of Allium species are the only example of plants that do not possess the simple telomere repeat sequences. Highly repetitive satellite and/or rDNA sequences are identified at the chromosome termini, suggesting that the ends are maintained by homologous recombination between repeats.
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(1996)
Chromosome Res
, vol.4
, pp. 207-213
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Pich, U.1
Fuchs, J.2
Schubert, I.3
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28
-
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0031010332
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Zepp, a LINE-like retrotransposon accumulated in the Chlorella telomeric region
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Higashiyama T, Noutoshi Y, Fujie M, Yamada T. Zepp, a LINE-like retrotransposon accumulated in the Chlorella telomeric region. EMBO. 16:1997;3715-3723.
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(1997)
EMBO
, vol.16
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Higashiyama, T.1
Noutoshi, Y.2
Fujie, M.3
Yamada, T.4
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29
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0028935097
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Linear mitochondrial DNAs from yeasts: Telomeres with large tandem repetitions
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Nosek J, Dinouel N, Kovac L, Fukuhara H. Linear mitochondrial DNAs from yeasts: telomeres with large tandem repetitions. Mol Gen Genet. 247:1995;61-72.
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Mol Gen Genet
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Nosek, J.1
Dinouel, N.2
Kovac, L.3
Fukuhara, H.4
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30
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Mechanisms of antigenic variation in Borrelia hermsii and African trypanosomes
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Donelson JE. Mechanisms of antigenic variation in Borrelia hermsii and African trypanosomes. J Biol Chem. 270:1995;7783-7786.
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J Biol Chem
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Donelson, J.E.1
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31
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0000369119
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Cytology of telomeres
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E.H. Blackburn, Greider C.W. Cold Spring Harbour, New York: Cold Spring Harbor Laboratory Press
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Dernburg AF, Sedat JW, Cande WZ, Bass HW. Cytology of telomeres. Blackburn EH, Greider CW. Telomeres. 1995;295-338 Cold Spring Harbor Laboratory Press, Cold Spring Harbour, New York.
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(1995)
Telomeres
, pp. 295-338
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Dernburg, A.F.1
Sedat, J.W.2
Cande, W.Z.3
Bass, H.W.4
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32
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0027423154
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SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres
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Palladino F, Laroche T, Gilson E, Axelrod A, Pillus L, Gasser SM. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell. 75:1993;543-555.
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(1993)
Cell
, vol.75
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Palladino, F.1
Laroche, T.2
Gilson, E.3
Axelrod, A.4
Pillus, L.5
Gasser, S.M.6
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33
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0028329781
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The chromosome end in yeast: Its mosaic nature and influence on recombinational dynamics
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Louis EJ, Naumova ES, Lee A, Naumov G, Haber JE. The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics. Genetics. 136:1994;789-802.
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Genetics
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Louis, E.J.1
Naumova, E.S.2
Lee, A.3
Naumov, G.4
Haber, J.E.5
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34
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0029827128
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Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex
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of special interest. The authors carry out a biochemical, immunocytochemical, and ultrastructural analysis of mammalian telomeres in interphase nuclei, with particular reference to the telomere-binding protein TRF. The results indicate that telomeres form discrete individual complexes that are associated with the nuclear matrix but do not form interactions with the nuclear lamina.
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Luderus ME, van Steensel B, Chong L, Sibon OC, Cremers FF, de Lange T. Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. of special interest J Cell Biol. 135:1996;867-881 The authors carry out a biochemical, immunocytochemical, and ultrastructural analysis of mammalian telomeres in interphase nuclei, with particular reference to the telomere-binding protein TRF. The results indicate that telomeres form discrete individual complexes that are associated with the nuclear matrix but do not form interactions with the nuclear lamina.
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(1996)
J Cell Biol
, vol.135
, pp. 867-881
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-
Luderus, M.E.1
Van Steensel, B.2
Chong, L.3
Sibon, O.C.4
Cremers, F.F.5
De Lange, T.6
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35
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0029820640
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The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae
-
of outstanding interest. A novel technique using combined immunofluorescence and in situ hybridisation is used here to demonstrate that Rap1p, Sir3p and Sir4p, proteins essential for telomeric silencing, colocalize with subtelomeric DNA sequences in S. cerevisiae. The colocalization is lost in Sir3 and Sir4 mutants whereas the clustering of subtelomeric sequences remains intact but less tightly defined.
-
Gotta M, Laroche T, Formenton A, Maillet L, Scherthan H, Gasser SM. The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. of outstanding interest J Cell Biol. 134:1996;1349-1363 A novel technique using combined immunofluorescence and in situ hybridisation is used here to demonstrate that Rap1p, Sir3p and Sir4p, proteins essential for telomeric silencing, colocalize with subtelomeric DNA sequences in S. cerevisiae. The colocalization is lost in Sir3 and Sir4 mutants whereas the clustering of subtelomeric sequences remains intact but less tightly defined.
-
(1996)
J Cell Biol
, vol.134
, pp. 1349-1363
-
-
Gotta, M.1
Laroche, T.2
Formenton, A.3
Maillet, L.4
Scherthan, H.5
Gasser, S.M.6
-
36
-
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0031049284
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RLF2, a subunit of yeast chromatin assembly factor-I, is required for telomeric chromatin function in vivo
-
of special interest. The authors identify a Rap1p localisation factor (RLF2) that is shown to be required for telomeric silencing and Rap1p localisation but does not effect telomeric distribution. It is proposed that Rlf2p facilitates efficient assembly of histones into telomeric chromatin.
-
Enomoto S, McCune-Zierath PD, Gerami-Nejad M, Sanders MA, Berman J. RLF2, a subunit of yeast chromatin assembly factor-I, is required for telomeric chromatin function in vivo. of special interest Genes Dev. 11:1997;358-370 The authors identify a Rap1p localisation factor (RLF2) that is shown to be required for telomeric silencing and Rap1p localisation but does not effect telomeric distribution. It is proposed that Rlf2p facilitates efficient assembly of histones into telomeric chromatin.
-
(1997)
Genes Dev
, vol.11
, pp. 358-370
-
-
Enomoto, S.1
McCune-Zierath, P.D.2
Gerami-Nejad, M.3
Sanders, M.A.4
Berman, J.5
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37
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0029048811
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A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei
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Konkel LMC, Enomoto S, Chamberlain EM, McCune-Zierath P, Iyadurai SJP, Berman J. A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei. Proc Natl Acad Sci USA. 92:1995;5558-5562.
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Proc Natl Acad Sci USA
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, pp. 5558-5562
-
-
Konkel, L.M.C.1
Enomoto, S.2
Chamberlain, E.M.3
McCune-Zierath, P.4
Iyadurai, S.J.P.5
Berman, J.6
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38
-
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0030916153
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Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae
-
of outstanding interest. This study identifies rDNA as the potential 'AGE' locus in yeast. Using indirect immunofluorescence, the authors show that Sir3p and Sir4p are redirected to the nucleolus in mutants that exhibit increased life span. This evidence contradicts the hypothesis that telomere shortening is responsible for ageing, at least in yeast.
-
Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM, Guarente L. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. of outstanding interest Cell. 89:1997;381-391 This study identifies rDNA as the potential 'AGE' locus in yeast. Using indirect immunofluorescence, the authors show that Sir3p and Sir4p are redirected to the nucleolus in mutants that exhibit increased life span. This evidence contradicts the hypothesis that telomere shortening is responsible for ageing, at least in yeast.
-
(1997)
Cell
, vol.89
, pp. 381-391
-
-
Kennedy, B.K.1
Gotta, M.2
Sinclair, D.A.3
Mills, K.4
McNabb, D.S.5
Murthy, M.6
Pak, S.M.7
Laroche, T.8
Gasser, S.M.9
Guarente, L.10
-
39
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0031014229
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Yeast telomeric sequences function as chromosomal anchorage points in vivo
-
of special interest. Using non-replicative DNA plasmids, containing yeast telomeric sequences, the authors determine which factors are required for telomeric anchorage in yeast. The simple telomeric repeat sequences and one trans acting factor, possibly Rap1p, are required. Other genes involved in telomeric silencing (SIR2-4) are shown not to be essential.
-
Mirabella A, Gartenberg MR. Yeast telomeric sequences function as chromosomal anchorage points in vivo. of special interest EMBO J. 16:1997;523-533 Using non-replicative DNA plasmids, containing yeast telomeric sequences, the authors determine which factors are required for telomeric anchorage in yeast. The simple telomeric repeat sequences and one trans acting factor, possibly Rap1p, are required. Other genes involved in telomeric silencing (SIR2-4) are shown not to be essential.
-
(1997)
EMBO J
, vol.16
, pp. 523-533
-
-
Mirabella, A.1
Gartenberg, M.R.2
-
41
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0029879223
-
The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human
-
of outstanding interest. This study identifies a Myb-related protein motif (telobox) that appears to be specialised for specific interactions with duplex telomeric DNA. The motif is found in proteins from yeast, plants and human. The differences between the yeast protein Rap1p and other telobox-containing proteins are discussed.
-
Bilaud T, Koering CE, Binet-Brasselet E, Ancelin K, Pollice A, Gasser SM, Gilson E. The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. of outstanding interest Nucleic Acids Res. 24:1996;1294-1303 This study identifies a Myb-related protein motif (telobox) that appears to be specialised for specific interactions with duplex telomeric DNA. The motif is found in proteins from yeast, plants and human. The differences between the yeast protein Rap1p and other telobox-containing proteins are discussed.
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 1294-1303
-
-
Bilaud, T.1
Koering, C.E.2
Binet-Brasselet, E.3
Ancelin, K.4
Pollice, A.5
Gasser, S.M.6
Gilson, E.7
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42
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