메뉴 건너뛰기




Volumn 20, Issue 8, 2000, Pages 2941-2948

Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres

Author keywords

[No Author keywords available]

Indexed keywords

RNA; TELOMERASE;

EID: 0034068910     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.8.2941-2948.2000     Document Type: Article
Times cited : (45)

References (45)
  • 1
    • 0029772312 scopus 로고    scopus 로고
    • Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae
    • Adams, A. K., and C. Holm. 1996. Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:4614-4620.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4614-4620
    • Adams, A.K.1    Holm, C.2
  • 2
    • 0032211413 scopus 로고    scopus 로고
    • Role of the telomeric DNA-binding protein TRF2 in the stability of human chromosome ends
    • Ancelin, K., C. Brun, and E. Gilson. 1998. Role of the telomeric DNA-binding protein TRF2 in the stability of human chromosome ends. Bioessays 20:879-883.
    • (1998) Bioessays , vol.20 , pp. 879-883
    • Ancelin, K.1    Brun, C.2    Gilson, E.3
  • 3
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn, E. H. 1991. Structure and function of telomeres. Nature 350: 569-573.
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 5
    • 0029843408 scopus 로고    scopus 로고
    • Identification of a saccharomyces cerevisiae Ku80 homologue: Roles double strand break rejoining and in telomeric maintenance
    • Boulton, S. J., and S. P. Jackson. 1996. Identification of a Saccharomyces cerevisiae Ku80 homologue: roles double strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24:4639-4648.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4639-4648
    • Boulton, S.J.1    Jackson, S.P.2
  • 6
    • 0031810967 scopus 로고    scopus 로고
    • Sir proteins, rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo
    • Bourns, B. D., M. K. Alexander, A. M. Smith, and V. A. Zakian. 1998. Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo. Mol. Cell. Biol. 18:5600-5608.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5600-5608
    • Bourns, B.D.1    Alexander, M.K.2    Smith, A.M.3    Zakian, V.A.4
  • 7
    • 0029155795 scopus 로고
    • Telomerase in yeast
    • Cohn, M., and E. H. Blackburn. 1995. Telomerase in yeast. Science 269: 396-400.
    • (1995) Science , vol.269 , pp. 396-400
    • Cohn, M.1    Blackburn, E.H.2
  • 8
    • 0031913710 scopus 로고    scopus 로고
    • Telomeric sequence diversity within the genus Saccharomyces
    • Cohn, M., M. J. McEachern, and E. H. Blackburn. 1998. Telomeric sequence diversity within the genus Saccharomyces. Curr. Genet. 33:83-91.
    • (1998) Curr. Genet. , vol.33 , pp. 83-91
    • Cohn, M.1    McEachern, M.J.2    Blackburn, E.H.3
  • 9
    • 0025222442 scopus 로고
    • RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability
    • Conrad, M. N., J. H. Wright, A. J. Wolf, and V. A. Zakian. 1990. RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell 63:739-750.
    • (1990) Cell , vol.63 , pp. 739-750
    • Conrad, M.N.1    Wright, J.H.2    Wolf, A.J.3    Zakian, V.A.4
  • 10
    • 0030807761 scopus 로고    scopus 로고
    • Coordinate regulation of G-and C strand length during new telomere synthesis
    • Fan, X., and C. M, Price. 1997. Coordinate regulation of G-and C strand length during new telomere synthesis. Mol. Biol. Cell 8:2145-2155.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 2145-2155
    • Fan, X.1    Price, C.M.2
  • 11
    • 0023037564 scopus 로고
    • Telomere proteins: Specific-recognition and protection of the natural termini of Oxytricha macronuclear DNA
    • Gottschling, D. E., and V. A. Zakian. 1986. Telomere proteins: specific-recognition and protection of the natural termini of Oxytricha macronuclear DNA. Cell 47:195-205.
    • (1986) Cell , vol.47 , pp. 195-205
    • Gottschling, D.E.1    Zakian, V.A.2
  • 12
    • 0032076127 scopus 로고    scopus 로고
    • Yeast Ku as a regulator of chromosomal DNA end structure
    • Gravel, S., M. Larrivee, P. Labrecque, and R. J. Wellinger. 1998. Yeast Ku as a regulator of chromosomal DNA end structure. Science 280:741-744.
    • (1998) Science , vol.280 , pp. 741-744
    • Gravel, S.1    Larrivee, M.2    Labrecque, P.3    Wellinger, R.J.4
  • 13
    • 0029894237 scopus 로고    scopus 로고
    • Telomere length regulation
    • Greider, C. W. 1996. Telomere length regulation. Annu. Rev, Biochem. 65: 337-365.
    • (1996) Annu. Rev, Biochem. , vol.65 , pp. 337-365
    • Greider, C.W.1
  • 14
    • 0032567975 scopus 로고    scopus 로고
    • Telomeres and senescence: The history, the experiment, the future
    • Greider, C. W. 1998. Telomeres and senescence: the history, the experiment, the future. Curr. Biol. 8:R178-R181.
    • (1998) Curr. Biol. , vol.8
    • Greider, C.W.1
  • 15
    • 0033593814 scopus 로고    scopus 로고
    • Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
    • Hande, M. P., E. Samper, P. Lansdorp, and M. A. Blasco. 1999. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144:589-601.
    • (1999) J. Cell Biol. , vol.144 , pp. 589-601
    • Hande, M.P.1    Samper, E.2    Lansdorp, P.3    Blasco, M.A.4
  • 16
    • 0024520745 scopus 로고
    • Site-directed mutagenesis by overlap extension using the polymerase chain reaction
    • Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
    • (1989) Gene , vol.77 , pp. 51-59
    • Ho, S.N.1    Hunt, H.D.2    Horton, R.M.3    Pullen, J.K.4    Pease, L.R.5
  • 17
    • 0032431057 scopus 로고    scopus 로고
    • Crystal structure of the oxytricha nova telomere end binking protein complexed with single strand DNA
    • Horvath, M. P., V. L. Schweiker, J. M. Bevilacqua, J. A. Ruggles, and S. C. Schultz. 1998. Crystal structure of the Oxytricha nova telomere end binking protein complexed with single strand DNA. Cell 95:963-974.
    • (1998) Cell , vol.95 , pp. 963-974
    • Horvath, M.P.1    Schweiker, V.L.2    Bevilacqua, J.M.3    Ruggles, J.A.4    Schultz, S.C.5
  • 19
    • 0033605145 scopus 로고    scopus 로고
    • p53-and ATM-dependent apoplosis induced by telomeres lacking TRF2
    • Karlseder, J., D. Broccoli, Y. Dai, S. Hardy, and T. de Lange. 1999. p53-and ATM-dependent apoplosis induced by telomeres lacking TRF2. Science 283: 1321-1325.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    De Lange, T.5
  • 20
    • 0031081482 scopus 로고    scopus 로고
    • Recognition of telomeric DNA
    • Konig, P., and D. Rhodes. 1997. Recognition of telomeric DNA. Trends Biochem. Sci. 22:43-47.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 43-47
    • Konig, P.1    Rhodes, D.2
  • 21
    • 0029743764 scopus 로고    scopus 로고
    • Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
    • Krauskopf, A., and E. H. Blackburn. 1996. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383: 354-357.
    • (1996) Nature , vol.383 , pp. 354-357
    • Krauskopf, A.1    Blackburn, E.H.2
  • 22
    • 0032514694 scopus 로고    scopus 로고
    • Rap1 protein regulates telomere turnover in yeast
    • Krauskopf, A., and E. H. Blackburn. 1998. Rap1 protein regulates telomere turnover in yeast. Proc. Natl. Acad. Sci. USA 95:12486-12491.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12486-12491
    • Krauskopf, A.1    Blackburn, E.H.2
  • 23
    • 0026657008 scopus 로고
    • C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae
    • Kyrion, G., K. A. Boakye, and A. J. Lustig. 1992. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol. Cell. Biol. 12:5159-5173.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5159-5173
    • Kyrion, G.1    Boakye, K.A.2    Lustig, A.J.3
  • 24
    • 0029778954 scopus 로고    scopus 로고
    • A novel mechanism for telomere size control in Saccharomyces cerevisiae
    • Li, B., and A. J. Lustig. 1996. A novel mechanism for telomere size control in Saccharomyces cerevisiae. Genes Dev. 10:1310-1326.
    • (1996) Genes Dev. , vol.10 , pp. 1310-1326
    • Li, B.1    Lustig, A.J.2
  • 25
    • 0030881688 scopus 로고    scopus 로고
    • Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity
    • Lingner, J., T. R. Cech, T. R. Hughes, and V. Lundblad. 1997. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc. Natl. Acad. Sci. USA 94:11190-11195.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 11190-11195
    • Lingner, J.1    Cech, T.R.2    Hughes, T.R.3    Lundblad, V.4
  • 26
    • 0027266758 scopus 로고
    • An alternative pathway for yeast telomere maintenance rescues estl-senescence
    • Lundblad, V., and E. H. Blackburn. 1993. An alternative pathway for yeast telomere maintenance rescues estl-senescence. Cell 73:347-360.
    • (1993) Cell , vol.73 , pp. 347-360
    • Lundblad, V.1    Blackburn, E.H.2
  • 27
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • Lundblad, V., and J. W. Szostak. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633-643.
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 28
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov, V. L., Y. Hirose, and J. P. Langmore. 1997. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88:657-666
    • (1997) Cell , vol.88 , pp. 657-666
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 29
    • 0031036351 scopus 로고    scopus 로고
    • A protein-counting mechanism for telomere length regulation in yeast
    • Marcand, S., E. Gilson, and D. Shore. 1997. A protein-counting mechanism for telomere length regulation in yeast. Science 275:986-990.
    • (1997) Science , vol.275 , pp. 986-990
    • Marcand, S.1    Gilson, E.2    Shore, D.3
  • 30
    • 0029746495 scopus 로고    scopus 로고
    • Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
    • McEachern, M. J., and E. H. Blackburn. 1996. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10:1822-1834.
    • (1996) Genes Dev. , vol.10 , pp. 1822-1834
    • McEachern, M.J.1    Blackburn, E.H.2
  • 31
    • 0029102354 scopus 로고
    • Runaway telomere elongation caused by telomerase RNA gene mutations
    • McEachern, M. J., and E. H. Blackburn. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376:403-409.
    • (1995) Nature , vol.376 , pp. 403-409
    • McEachern, M.J.1    Blackburn, E.H.2
  • 32
    • 0029845892 scopus 로고    scopus 로고
    • Cdc13p: A single-strand telomeric DNA-hinding protein with a dual role in yeast telomere maintenance
    • Nugent, C. I., T. R. Hughes, N. F. Lue, and V. Lundblad. 1996. Cdc13p: a single-strand telomeric DNA-hinding protein with a dual role in yeast telomere maintenance. Science 274:249-252.
    • (1996) Science , vol.274 , pp. 249-252
    • Nugent, C.I.1    Hughes, T.R.2    Lue, N.F.3    Lundblad, V.4
  • 33
    • 0030781067 scopus 로고    scopus 로고
    • Functionally interacting telomerase RNAs in the yeast telomerase complex
    • Prescott, J., and E. H. Blackburn. 1997. Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:2790-2800.
    • (1997) Genes Dev. , vol.11 , pp. 2790-2800
    • Prescott, J.1    Blackburn, E.H.2
  • 34
    • 0031029377 scopus 로고    scopus 로고
    • Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro
    • Prescott, J., and E. H. Blackburn. 1997. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. Genes Dev. 11:528-540.
    • (1997) Genes Dev. , vol.11 , pp. 528-540
    • Prescott, J.1    Blackburn, E.H.2
  • 35
    • 0023742169 scopus 로고
    • Generation of telomere-length heterogeneity in Saccharomyces cerevisiae
    • Shampay, J., and E. H. Blackburn. 1988. Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 85: 534-538.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 534-538
    • Shampay, J.1    Blackburn, E.H.2
  • 36
    • 0028130685 scopus 로고
    • RAP1: A protean regulator in yeast
    • Shore, D. 1994. RAP1: a protean regulator in yeast. Trends Genet 10: 408-412.
    • (1994) Trends Genet , vol.10 , pp. 408-412
    • Shore, D.1
  • 37
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyees cerevisiae telomerase
    • Singer, M. S., and D. E. Gottschling. 1994. TLC1: template RNA component of Saccharomyees cerevisiae telomerase. Science 266:404-409.
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 38
    • 0345643517 scopus 로고    scopus 로고
    • Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
    • Smith, C. D., and E. H. Blackburn. 1999. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast. J. Cell Biol. 145:203-214.
    • (1999) J. Cell Biol. , vol.145 , pp. 203-214
    • Smith, C.D.1    Blackburn, E.H.2
  • 39
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • van Steensel, B., and T. de Lange. 1997. Control of telomere length by the human telomeric protein TRF1. Nature 385:740-743.
    • (1997) Nature , vol.385 , pp. 740-743
    • Van Steensel, B.1    De Lange, T.2
  • 40
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., A. Smogorzewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 41
    • 0030462146 scopus 로고    scopus 로고
    • Est1 has the properties of a single-stranded telomere end-binding protein
    • Virta-Pearlman, V., D. K. Morris, and V. Lundblad. 1996. Est1 has the properties of a single-stranded telomere end-binding protein. Genes Dev. 10:3094-3104.
    • (1996) Genes Dev. , vol.10 , pp. 3094-3104
    • Virta-Pearlman, V.1    Morris, D.K.2    Lundblad, V.3
  • 42
    • 0032481419 scopus 로고    scopus 로고
    • A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase
    • Wang, H., D. Gilley, and E. H. Blackburn. 1998. A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase. EMBO J. 17:1152-1160.
    • (1998) EMBO J. , vol.17 , pp. 1152-1160
    • Wang, H.1    Gilley, D.2    Blackburn, E.H.3
  • 43
    • 0027509950 scopus 로고
    • Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase
    • Wellinger, R. J., A. J. Wolf, and V. A. Zakian. 1993. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell 72:51-60.
    • (1993) Cell , vol.72 , pp. 51-60
    • Wellinger, R.J.1    Wolf, A.J.2    Zakian, V.A.3
  • 44
    • 0029563009 scopus 로고
    • Telomeres: Beginning to understand the end
    • Zakian, V. A. 1995. Telomeres: beginning to understand the end. Science 270:1601-1607.
    • (1995) Science , vol.270 , pp. 1601-1607
    • Zakian, V.A.1
  • 45
    • 0033616762 scopus 로고    scopus 로고
    • Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
    • Zhu, J., H. Wang, J. M. Bishop, and E. H. Blackburn. 1999. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA 96:3723-3728.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3723-3728
    • Zhu, J.1    Wang, H.2    Bishop, J.M.3    Blackburn, E.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.