Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase

Molecular and Cellular Biology

Volumn 16, Issue 1, 1996, Pages 66-75

  Gilley, David ^a   Blackburn, Elizabeth H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TETRAHYMENA; TETRAHYMENA THERMOPHILA;

PROTOZOAL PROTEIN; RNA;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TETRAHYMENA THERMOPHILA;

ANIMAL; BASE COMPOSITION; BASE SEQUENCE; BINDING SITES; DNA PRIMERS; DNA, PROTOZOAN; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; RNA, PROTOZOAN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TELOMERASE; TETRAHYMENA THERMOPHILA;

EID: 0029655261     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.1.66     Document Type: Article

References (35)

1. Autexier, C., and C. W. Greider. 1994, Functional reconstitution of wild-type and mutant Tetrahymena telomerase. Genes Dev. 8:563-575.
2. Bebenek, K., and T. A. Kunkel. 1993 The fidelity of retroviral reverse transcriptases, p. 85-103 In A. M. Skalka and S. P. Goff (ed.), Reverse transcriptase Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
3. Bhattacharyya, A., and E. H. Blackburn. 1994. Architecture of telomerase RNA. EMBO J. 13:5721-5731.
4. Blackburn, E. H. 1992. Telomerases. Annu. Rev. Biochem 61:113-129.
5. Blackburn, E. H. 1994. Telomeres: no end in sight. Cell 77:621-623.
6. Cohn, M., and E. H. Blackburn. 1995. Telomerase in yeast. Science 269: 396-400.
7. Collins, K., and C. W. Greider. 1993. Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation Genes Dev. 7:1364-1376.
8. Collins, K., and C. W. Greider. 1995. Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell 81:677-686
9. Gaertig, J., and M. A. Gorovsky. 1992. Efficient mass transformation of Tetrahymena thermophila by electroporation of conjugants Proc. Natl Acad Sci. USA 89:9196-9200.
10. Gilley, D., and E. H. Blackburn. Unpublished data.
11. Gilley, D., M. Lee, and E. H. Blackburn. 1995 Altering specific telomerase RNA template residues affects active site function Genes Dev 9:2214-2226
12. Greider, C. W., and E. H. Blackburn. 1987 The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51:887-898.
13. Greider, C. W., and E. H. Blackburn. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature (London) 337:331-337.
14. Harrington, L., C. Hull, J. Crittenden, and C. Greider. Gel shift and UV cross-linking analysis of Tetrahymena telomerase J. Biol Chem. 270:8893-8901.
15. Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
16. Kohlstaedt, L. A., J. Wang, J. M. Friedman, P. A. Rice, and T. A. Steitz. 1992. Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256:1783-1790.
17. Kunkel, T. A. 1992. DNA replication fidelity. J Biol. Chem 267:18251-18254.
18. Lee, M. S., and E. H. Blackburn. 1993 Sequence-specific DNA primer effects on telomerase polymerization activity. Mol. Cell. Biol. 13:6586-6599.
19. Lee, M. S., R. C. Gallagher, J. Bradley, and E. H. Blackburn. 1993. In vivo and in vitio studies of telomeres and telomerase. Cold Spring Harbor Symp Quant. Biol 58:707-718.
20. Lin, J.-J., and V. A. Zakian. 1995. An in vitro assay for Saccharomyces telomerase requires EST1. Cell 81:1127-1135.
21. Lingner, J., L. L. Hendrick, and T. R. Cech. 1994. Telomerase RNAs of different ciliates have a commun secondary structure and a permuted template. Genes Dev. 8:1984-1998.
22. Mantell, L. L., and C. W. Greider. 1994 Telomerase activity in germline and embryonic cells of Xenopus. EMBO J. 13:3211-3217
23. McCormick-Graham, M., and D. P. Romero. 1995. Ciliate telomerase RNA structural features Nucleic Acids Res. 23:1091-1097.
24. Morin, G. B. 1991. Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase. Nature (London) 353:454-456.
25. Ollis, D. L., P. Brick, R. Hamlin, N. G. Xuong, and T. A. Steitz. 1985. Structure of large fragment of Excherichia coli DNA polymerase I complexed with dTMP. Nature (London) 313:762-766.
26. Prowse, K. R., A. A. Avilion, and C. W. Greider. 1993 Identification of a nonprocessive telomerase activity from mouse cell. Proc. Natl Acad. Sci USA 90:1493-1497
27. Romero, D. P., and E. H. Blackburn. 1991 A conserved secondary structure for telomerase RNA. Cell 67:343-353.
28. Romero, D. P., and E. H. Blackburn. 1995. Circular rDNA replicons persist in Tetrahymena thermoplula transformants synthesizing GGGGTC telomeric repeats. J. Eukaryot. Microbiol. 42:32-43
29. Shippen-Lentz, D., and E. H. Blackburn. 1990. Functional evidence for an RNA template in telomerase. Science 247:546-552.
30. Sousa, R., Y. J. Chung, J. P. Rose, and B.-C. Wang. 1993. Crystal structure of bactenophage T7 RNA polymerase at 3.3 A resolution Nature (London) 364:593-599.
31. ten Dam, E., A. van Belkum, and K. Pleij. 1991. A conserved pseudoknot in telomerase RNA. Nucleic Acids Res. 19:6951.
32. Yu, G.-L., and E. H. Blackburn. 1989. Transformation of Tetrahyena thermophila with a mutated circular ribosomal DNA plasmid vector. Proc. Natl Acad Sci. USA 86:8487-8491.
33. Vu, G.-L., and E. H. Blackburn. 1991. Developmentally programmed healing of chromosomes by telomerase in Tetrahymena Cell 67:823-832.
34. Yu, G.-L., J. D. Bradley, L. D. Attardi, and E. H. Blackburn. 1990. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature (London) 344:126-132.
35. Zaug, A. J., and T. R. Cech. 1995 Analysis of the structure of Tetrahymena nuclear RNAs in vivo telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. RNA 1:363-374.