A role for DNA-PK in retroviral DNA integration

Science

Volumn 284, Issue 5414, 1999, Pages 644-647

  Daniel, René ^a   Katz, Richard A ^a   Skalka, Anna Marie ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; INTEGRASE; VIRUS DNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CATALYSIS; CELL KILLING; CELL VIABILITY; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DNA INTEGRATION; DNA REPAIR; ENZYME ACTIVITY; GENETIC RECOMBINATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RETROVIRUS; VIRUS DNA CELL DNA INTERACTION; VIRUS REPLICATION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CHO CELLS; CRICETINAE; DNA DAMAGE; DNA REPAIR; DNA, VIRAL; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; GENETIC VECTORS; HIV-1; INTEGRASES; MICE; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RETROVIRIDAE; VIRUS INTEGRATION; VIRUS REPLICATION;

ANIMALIA; DNA VIRUSES; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0033597450     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.284.5414.644     Document Type: Article

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45. We thank M. Bosma, R. Perry, and C. Seeger for critical comments on the manuscript; J. Kulkosky and R. Pomeraritz for help with the HIV-1-based vector experiments; M. Bosma and G. Bosma for the scid and wild-type mouse cell lines and fibroblasts; S. Hughes for the ASV vector; I. Verma for the HIV-1 vertor; D. B. Roth and M. Oettinger for helpful advice and cell lines; P. A. Jeggo for the Ku86(-) cells; and T. D. Stamato for the XRCC4(-) cells. Supported by NIH grants CA71515, AI40385, AI40721, and CA06927 and by an appropriation from the Commonwealth of Pennsylvania.