Update on antiviral DNA vaccine research (1998-2000)

Intervirology

Volumn 43, Issue 4-6, 2000, Pages 197-217

  Schultz, Jan ^a   Dollenmaier, Günter ^a   Mölling, Karin ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Antigen presentation; DNA carriers; DNA vaccines, antiviral; Genetic adjuvants

Indexed keywords

DNA VACCINE; ENVELOPE PROTEIN; GAG PROTEIN; GLYCOPROTEIN; GLYCOPROTEIN B; GLYCOPROTEIN E; GLYCOPROTEIN GP 160; GUANINE NUCLEOTIDE BINDING PROTEIN; HEPATITIS ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN; PROTEIN C; REV PROTEIN; REX PROTEIN; THROMBOSPONDIN; TRANSACTIVATOR PROTEIN; VIRUS DNA; VIRUS ENVELOPE PROTEIN; VIRUS VECTOR;

CELLULAR IMMUNITY; DRUG EFFICACY; GENE GUN; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; REVIEW; RHESUS MONKEY; SYRIAN HAMSTER; VACCINATION;

ANIMALS; ANTIGENS, VIRAL; HUMANS; RESEARCH; VACCINES, DNA; VIRAL VACCINES; VIRUS DISEASES;

EID: 0034469443     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053988     Document Type: Review

References (162)

1. DNA vaccines
2. Immune responses to DNA vaccines
3. DNA vaccines: Immunology, application, and optimization
4. Intramuscular inoculation of Sin Nombre hantavirus cDNAs induces cellular and humoral immune responses in BALB/c mice
5. DNA-based vaccine against La Crosse virus: Protective immune response mediated by neutralizing antibodies and CD4+ T cells
6. DNA-based immunization produces Th1 immune responses to hepatitis delta virus in a mouse model
7. Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein
8. A single intramuscular injection of recombinant plasmid DNA induces protective immunity and prevents Japanese encephalitis in mice
9. A DNA vaccine expressing dengue type 2 virus premembrane and envelope genes induces neutralizing antibody and memory B cells in mice
10. Immunization with plasmid DNA encoding the envelope glycoprotein of Japanese encephalitis virus confers significant protection against intracerebral viral challenge without inducing detectable antiviral antibodies
11. DNA-based and alphavirus-vectored immunisation with prM and E proteins elicits long-lived and protective immunity against the flavivirus, Murray Valley encephalitis virus
12. Evaluation of tick-borne encephalitis DNA vaccines in monkeys
13. Induction of neutralizing antibody against human cytomegalovirus (HCMV) with DNA-mediated immunization of HCMV glycoprotein B in mice
14. Induction of human cytomegalovirus (HCMV)-glycoprotein B (gB)-specific neutralizing antibody and phosphoprotein 65 (pp65)-specific cytotoxic T lymphocyte responses by naked DNA immunization
15. Analysis of immune responses to varicella zoster viral proteins induced by DNA vaccination
16. Development of a rubella virus DNA vaccine
17. Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques
18. Successful DNA immunization against measles: Neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles
19. DNA immunization of mice and macaques with plasmids encoding hepatitis C virus envelope E2 protein expressed intracellularly and on the cell surface
20. Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus
21. Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees
22. Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes
23. DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans
24. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations
25. Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys
26. Immunization of dogs and cats with a DNA vaccine against rabies virus
27. DNA vaccines: Protective immunizations by parenteral, mucosal, and gene-gun inoculations
28. DNA-based noninvasive vaccination onto the skin
29. Poly(DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration
30. Protective immunity induced by oral immunization with a rotavirus DNA vaccine encapsulated in microparticles
31. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses
32. Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein
33. Liposome-mediated DNA vaccination
34. Targeting immune response induction with cochleate and liposome-based vaccines
35. Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes
36. Recent advances with recombinant bacterial vaccine vectors
37. Heterologous protection against influenza by injection of DNA encoding a viral protein
38. Direct gene transfer into nonhuman primate myofibers in vivo
39. DNA vaccine for hepatitis B: Evidence for immunogenicity in chimpanzees and comparison with other vaccines
40. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle
41. Comparisons of DNA-mediated immunization procedures directed against surface glycoproteins of human immunodeficiency virus type-1 and hepatitis B virus
42. Conditions affecting direct gene transfer into rodent muscle in vivo
43. Direct gene transfer into skeletal muscle in vivo: Factors affecting efficiency of transfer and stability of expression
44. Plasmid delivery to muscle: Recent advances in polymer delivery systems
45. Characterization of plasmid DNA transfer into mouse skeletal muscle: Evaluation of uptake mechanism, expression and secretion of gene products into blood
46. Pharmacological enhancement of in vivo foreign gene expression in muscle
47. Effects of DNA immunization formulated with bupivacaine in murine and guinea pig models of genital herpes simplex virus infection
48. DNA immunization with HIV-1 tat mutated in the trans activation domain induces humoral and cellular immune responses against wild-type Tat
49. DNA-based immunization against hepatitis B surface antigen (HBsAg) in normal and HBsAg-transgenic mice
50. HIV-1 DNA vaccines
51. Gene transfer into muscle by electroporation in vivo
52. Cross-protection against a lethal influenza virus infection by DNA vaccine to neuraminidase
53. Protection against influenza virus infection in mice immunized by administration of hemagglutinin-expressing DNAs with electroporation
54. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo
55. Electropermeabilization of skeletal muscle enhances gene transfer in vivo
56. Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses
57. Particle-mediated nucleic acid immunization
58. DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge
59. Gene gun particle-mediated vaccination with plasmid DNA confers protective immunity against rabies virus infection
60. Induction of cytotoxic T-cell responses by gene gun DNA vaccination with minigenes encoding influenza A virus HA and NP CTL-epitopes
61. Gene gun DNA vaccination with Rev-independent synthetic HIV-1 gp160 envelope gene using mammalian codons
62. Immunity obtained by gene-gun inoculation of a rotavirus DNA vaccine to the abdominal epidermis or anorectal epithelium
63. DNA vaccination of mice with plasmid expressing human papillomavirus 6 major capsid protein L1 elicits type-specific antibodies neutralizing pseudovirions constructed in vitro
64. Efficient vaccination by intradermal or intramuscular inoculation of plasmid DNA expressing hepatitis B surface antigen under desmin promoter/enhancer control
65. Immune responses to hepatitis C virus structural and nonstructural proteins induced by plasmid DNA immunizations
66. Direct gene transfer into mouse muscle in vivo
67. In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair
68. Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations
69. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization
70. Gene gun-based nucleic acid immunization: Elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA
71. Mucosal immunization with DNA encoding influenza hemagglutinin
72. Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization
73. Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes
74. Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine
75. Adjuvant effect of Ubenimex on a DNA vaccine for HIV-1
76. Protective immunity induced by rotavirus DNA vaccines
77. Immune responses and protection obtained by oral immunization with rotavirus VP4 and VP7 DNA vaccines encapsulated in microparticles
78. Mucosal immunization with a DNA vaccine induces immune responses against HIV-1 at a mucosal site
79. Cationic microparticles: A potent delivery system for DNA vaccines
80. A novel immunization method to induce cytotoxic T-lymphocyte responses (CTL) against plasmid-encoded herpes simplex virus type-1 glycoprotein D
81. Murine response to DNA encoding herpes simplex virus type-1 glycoprotein D targeted to the liver
82. Cationic liposomes are a strong adjuvant for a DNA vaccine of human immunodeficiency virus type 1
83. HIV-1-specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti-interferon-gamma antibody
84. Intranasal administration of human immunodeficiency virus type-1 (HIV-1) DNA vaccine with interleukin-2 expression plasmid enhances cell-mediated immunity against HIV-1
85. Immune response to a hepatitis B DNA vaccine in Aotus monkeys: A comparison of vaccine formulation, route, and method of administration
86. Enhancement of mucosal immune responses to the influenza virus HA protein by alternative approaches to DNA immunization
87. Mucosal DNA vaccine immunization against measles with a highly attenuated Shigella flexnerivector
88. Oral somatic transgene vaccination using attenuated S. typhimurium
89. Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization
90. Listeria monocyto-genes: A potent vaccine vector for neoplastic and infectious disease
91. Alphavirus expression vectors and their use as recombinant vaccines: A minireview
92. Enhancing immune responses using suicidal DNA vaccines
93. Layered amplification of gene expression with a DNA gene delivery system
94. DNA immunization against herpes simplex virus: Enhanced efficacy using a Sindbis virus-based vector
95. Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells
96. The immune response to a polyoma virus replicon-based DNA vaccine
97. BAC-VAC, a novel generation of (DNA) vaccines: A bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1
98. Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: Rescue of replication-competent virus progeny and packaging of amplicon vectors
99. DNA vaccines to rabies virus: Effects of cytokines on the immune response
100. Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte-macrophage colony-stimulating factor gene
101. Enhancement of protective humoral (Th2) and cell-mediated (Th1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte-macrophage colony-stimulating factor expression cassettes
102. DNA inoculations with HIV-1 recombinant genomes that express cytokine genes enhance HIV-1 specific immune responses
103. Enhanced protection against viral infection by co-administration of plasmid DNA coding for viral antigen and cytokines in mice
104. In vivo modulation of vaccine-induced immune responses toward a Th1 phenotype increases potency and vaccine effectiveness in a herpes simplex virus type 2 mouse model
105. Modulation of the immune response to DNA vaccine by co-delivery of costimulatory molecules
106. Macrophage inflammatory protein-1alpha (MIP-1alpha) expression plasmid enhances DNA vaccine-induced immune response against HIV-1
107. LFA-3 plasmid DNA enhances Ag-specific humoral- and cellular-mediated protective immunity against herpes simplex virus-2 in vivo: Involvement of CD4+ T cells in protection
108. A single immunization with a plasmid encoding hepatitis C virus (HCV) structural proteins under the elongation factor 1-alpha promoter elicits HCV-specific cytotoxic T-lymphocytes (CTL)
109. DNA immunization utilizing a herpes simplex virus type 2 myogenic DNA vaccine protects mice from mortality and prevents genital herpes
110. Effect of different promoters on immune responses elicited by HIV-1 gag/env multigenic DNA vaccine in Macaca mulatta and macaca nemestrina
111. Targeted expression of HTLV-I envelope proteins in muscle by DNA immunization of mice
112. 8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine
113. Utilization of MHC class I transgenic mice for development of minigene DNA vaccines encoding multiple HLA-restricted CTL epitopes
114. Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime
115. Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization
116. Protective cytotoxic T lymphocyte responses against paramyxoviruses induced by epitope-based DNA vaccines: Involvement of IFN-gamma
117. DNA immunization: Ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction
118. Induction of MHC class I-restricted CTL response by DNA immunization with ubiquitin-influenza virus nucleoprotein fusion antigens
119. Targeting of hepatitis C virus core protein for MHC I or MHC II presentation does not enhance induction of immune responses to DNA vaccination
120. Enhancement of antibody responses by DNA immunization using expression vectors mediating efficient antigen secretion
121. DNA immunization: Effect of secretion of DNA-expressed hemagglutinins on antibody responses
122. Immunization with a plasmid encoding a modified hepatitis B surface antigen carrying the receptor binding site for hepatocytes
123. A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge
124. Improved immunogenicity of HIV-1 epitopes in HBsAg chimeric DNA vaccine plasmids by structural mutations of HBsAg
125. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration
126. Targeted cytokines for cancer immunotherapy
127. Facile generation and use of immunogenic polypeptide fusions to a sparingly soluble non-antigenic protein carrier
128. Enhancement of immunoglobulin G2a and cytotoxic T-lymphocyte responses by a booster immunization with recombinant hepatitis C virus E2 protein in E2 DNA-primed mice
129. Studies of the neutralizing activity and avidity of anti-human immunodeficiency virus type 1 Env antibody elicited by DNA priming and protein boosting
130. A novel vaccine regimen utilizing DNA, vaccinia virus and protein immunizations for HIV-1 envelope presentation
131. Induction of neonatal tolerance by plasmid DNA vaccination of mice
132. Protective cellular immunity against influenza virus induced by plasmid inoculation of newborn mice
133. Enhanced protection against influenza virus of mice immunized as newborns with a mixture of plasmids expressing hemagglutinin and nucleoprotein
134. Immunogenicity and efficacy of DNA vaccines encoding influenza A proteins in aged mice
135. Fetal immunization by a DNA vaccine delivered into the oral cavity
136. Plasmid DNA vaccines are effective in the absence of IFNgamma
137. DNA vaccination with hantavirus M segment elicits neutralizing antibodies and protects against Seoul virus infection
138. Genetic immunization generates cellular and humoral immune responses against the non-structural proteins of the hepatitis C virus in a murine model
139. Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating factor gene in intramuscular DNA immunization
140. A dengue virus serotype-1 DNA vaccine induces virus neutralizing antibodies and provides protection from viral challenge in Aotus monkeys
141. A comparison of the immune response induced by DNA or by an inactivated vaccine against tick-borne encephalitis (in Russian)
142. Phase 1 safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device
143. Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization
144. DNA-mediated immunization to hepatitis B virus envelope proteins: PreS antigen secretion enhances the humoral response
145. Immunity induced by DNA immunization with herpes simplex virus type 2 glycoproteins B and C
146. Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations
147. DNA vaccine encoding hemagglutinin provides protective immunity against H5N1 influenza virus infection in mice
148. Protection and antibody responses in different strains of mouse immunized with plasmid DNAs encoding influenza virus haemagglutinin, neuraminidase and nucleoprotein
149. Enhanced protection against a lethal influenza virus challenge by immunization with both hemagglutinin- and neuraminidase-expressing DNAs
150. Dose dependence of CTL precursor frequency induced by a DNA vaccine and correlation with protective immunity against influenza virus challenge
151. DNA vaccination with both the haemagglutinin and fusion proteins but not the nucleocapsid protein protects against experimental measles virus infection
152. Plasmid DNA encoding the respiratory syncytial virus G protein is a promising vaccine candidate
153. Particle-bombardment-mediated DNA vaccination with rotavirus VP4 or VP7 induces high levels of serum rotavirus IgG but fails to protect mice against challenge
154. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine
155. Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines
156. Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment
157. Induction of mucosal IgA by a novel jet delivery technique for HIV-1 DNA
158. DNA vaccination of mice against rabies virus: Effects of the route of vaccination and the adjuvant monophosphoryl lipid A (MPL)
159. Manipulation of HIV-1 gp120-specific immune responses elicited via gene gun-based DNA immunization
160. Screening of protective antigens of Japanese encephalitis virus by DNA immunization: A comparative study with conventional viral vaccines
161. A DNA immunization model study with constructs expressing the tick-borne encephalitis virus envelope protein E in different physical forms
162. Japanese encephalitis DNA vaccine candidates expressing premembrane and envelope genes induce virus-specific memory B cells and long-lasting antibodies in swine