IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine

Vaccine

Volumn 17, Issue 7-8, 1999, Pages 858-866

  Xin, Ke Qin ^a,b   Hamajima, Kenji ^a   Sasaki, Shin ^a   Tsuji, Takashi ^a   Watabe, Setsuko ^a   Okada, Eiichi ^a   Okuda, Kenji ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

DNA vaccine; HIV 1; Interleukin 15

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DELAYED HYPERSENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE THERAPY; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INTRAMUSCULAR DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; AMINO ACID SEQUENCE; ANIMALS; CYTOKINES; DNA, VIRAL; DRUG SYNERGISM; FECES; FEMALE; HIV ANTIBODIES; HIV-1; HYPERSENSITIVITY, DELAYED; IMMUNITY, CELLULAR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; INTERLEUKIN-12; INTERLEUKIN-15; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PLASMIDS; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, DNA;

EID: 0033605274     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00271-0     Document Type: Article

References (41)

1. Bukawa H., Sekigawa K., Hamajima K.et al. Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate. Nat. Med. 1:1995;681-685.
2. Bukawa H., Fukushima J., Hamajima K.et al. Antibody responses raised against a conformational V3 loop peptide of HIV-1. Microbiol. Immunol. 39:1995;607-614.
3. Okuda K., Kaneko T., Yamakawa T.et al. Strong immunogenicity of a multicomponent vaccine developed with the branched lysine oligopeptide (BLO) method for human immunodeficiency virus-1 (HIV-1) infection. J. Mol. Recognition. 6:1993;101-109.
4. Okuda K., Bukawa H., Hamajima K.et al. Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV-1 env and rev gene products. AIDS Res. Hum. Retrov. 11:1995;933-943.
5. Germain R.N. The ins and outs of antigen processing and presentation. Nature. 322:1986;687-689.
6. Donnelly J.J., Ulmer J.B., Shiver J.W., Liu M.A. DNA vaccines. Annu. Rev. Immunol. 15:1997;617-648.
7. Giri J.G., Anderson D.M., Kumaki S., Park L.S., Grabstein K.H., Cosman D. IL-15, a novel T-cell growth factor that shares activities and receptor components with IL-2. J. Leukocyte Biol. 57:1995;763-766.
8. Armitage R.J., Macduff B.M., Paxton R., Grabstein K. IL-15 has stimulatory activity for the induction of B-cell proliferation and differentiation. J. Immunol. 154:1995;483-490.
9. Grabstein K.H., Eisenman J., Shanebeck K.et al. Cloning of a T-cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science. 264:1994;965-968.
10. Carson W.E., Ross M.E., Baiocchi R.A.et al. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells. J. Clin. Invest. 96:1995;2578-2582.
11. Carson W.E., Giri J.G., Lindenmann M.J.et al. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:1994;1395-1403.
12. Anderson D.M., Johnson L., Glaccum M.et al. Chromosomal assignment and genomic structure of IL15. Genomics. 25:1995;701-706.
13. Anderson D.M., Kumaki S., Ahdieh M.et al. Functional characterization of the human interleukin-15 receptor α chain and close linkage of IL15Rα and IL2Rα genes. J. Biol. Chem. 270:1995;29862.
14. Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T helper cells type 1 and cytotoxic lymphocytes. Blood. 84:1994;4008-4027.
15. Malim M.H., Hauber J., Fenrick R., Cullen B.R. Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. Nature. 335:1988;181-183.
16. Karasuyama H., Tohyama N., Tada T. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T-cells transfected with IL-2 gene. J. Exp. Med. 169:1989;13-25.
17. Tsuji T., Hamajima K., Fukushima J.et al. Enhancement of cell-mediated immunity against HIV-1 induced by coinoculation of plasmid-encoded HIV-1 antigen with plasmid expressing interleukin-12. J. Immunol. 158:1997;4008-4013.
18. Ishii N., Fukushima J., Kaneko T.et al. Cationic liposomes are a strong adjuvant for a human immunodeficiency virus type-1 (HIV-1) vaccine candidate constructed with HIV-1 env and rev genes. AIDS Res. Hum. Retrov. 13:1997;1421-1428.
19. + cytotoxic T-cell by immunization with purified HIV-1 envelope protein in ISCOMs. Nature (London). 344:1990;873-875.
20. Shirai M., Kozlowski S., Margulies D.H., Berzofsky J.A. Degenerate MHC restriction reveals the contribution of class I MHC molecules in determining the fine specificity of CTL recognition of an immunodominant determinant of HIV-1 gp160 V3 loop. J. Immunol. 158:1997;3181-3188.
21. Clerici M., Lucey D., Zajac R.et al. Detection of cytotoxic T lymphocytes specific for synthetic peptides of gp160 in HIV-seropositive individual. J. Immunol. 146:1991;2214-2219.
22. Staats F.H., Nichols W.G., Palker T.J. Systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide TSP10MN (A). J. Immunol. 157:1996;462-472.
23. Shirai A., Sierra V., Kelly C.I., Klinman D. Individual cells simultaneously produce both IL-4 and IL-6 in vivo. Cytokine. 6:1994;329-336.
24. Miedema F., Klein M.R. AIDS pathogenesis: a finite immune response to blame? Science. 272:1996;505-506.
25. Haynes B.F., Pantaleo G., Fauci A.S. Toward an understanding of the correlates of protective immunity to HIV infection. Science. 271:1996;324-328.
26. Koup R.A., Safrit J.T., Cao Y.et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:1994;4650-4655.
27. + T-cells with a predominant Vβ usage during the primary immune response to HIV. Nature. 370:1994;463-467.
28. Klein M.R., van-Baalen C.A., Holwerda A.M.et al. Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J. Exp. Med. 181:1995;1365-1372.
29. Langlade-Demoyen P., Ngo-Giang-Huong N., Ferchal F., Oksenhendler E. Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients. J. Clin. Invest. 93:1994;1293-1297.
30. Rowland-Jones S., Sutton J., Ariyoshi K.et al. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nat. Med. 1:1995;59-64.
31. Kanai T., Thomas E.K., Yasutomi Y., Letvin N.L. IL-15 stimulates the expansion of AIDS virus-specific CTL. J. Immunol. 157:1996;3681-3687.
32. Kim J.J., Trivedi N.N., Nottingham L.K.et al. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. Eur. J. Immunol. 28:1998;1089-1103.
33. Sato Y., Roman M., Tighe H.et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science. 273:1996;352-354.
34. Clerici M., Shearer G.M. A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunol. Today. 14:1993;107-111.
35. Scott P. IL-12: initiation cytokine for cell-mediated immunity. Science. 260:1993;496-497.
36. Giri J.G., Kumaki S., Ahdieh M.et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor. EMBO J. 14:1995;3654-3663.
37. Xin K-Q, Hamajima K, Sasaki S et al. Intranasal administration of HIV-1 DNA vaccine with IL-2 expression plasmid enhances cell-mediated immunity against HIV-1. Immunol. 1998 (in press).
38. Giri J.G., Ahdieh M., Eisenman J.et al. Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:1994;2822-2830.
39. Fynan E.F., Webster R., Fuller D., Haynes J., Santoro J., Robinson H. DNA vaccines: a novel approach to immunization. Int. J. Immunopharmac. 17:1995;79-83.
40. Staats H.F., Jackson R.J., Marinaro M., Takahashi I., Kiyono H., McGhee J.R. Mucoasl immunity to infection with implications for vaccine development. Curr. Opin. Immunol. 6:1994;572-583.
41. Russell M.W., Moldoveanu Z., White P.L., Sibert G.J., Mestecky J., Michalek S.M. Salivary, nasal, genital and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect. Immun. 64:1996;1272-1283.