메뉴 건너뛰기




Volumn 18, Issue 8, 1999, Pages 611-621

Targeting of hepatitis C virus core protein for MHC I or MHC II presentation does not enhance induction of immune responses to DNA vaccination

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; CYTOKINE; DNA VACCINE; MEMBRANE PROTEIN; UBIQUITIN;

EID: 0032785706     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454999315024     Document Type: Article
Times cited : (52)

References (54)
  • 1
    • 0030826097 scopus 로고    scopus 로고
    • Immune responses throughout hepatitis C virus (HCV) infection: HCV from the immune system point of view
    • ABRIGNANI, S. (1997). Immune responses throughout hepatitis C virus (HCV) infection: HCV from the immune system point of view. Semin. Immunpathol. 19, 47-55.
    • (1997) Semin. Immunpathol. , vol.19 , pp. 47-55
    • Abrignani, S.1
  • 2
    • 0028200118 scopus 로고
    • Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes
    • AMIGORENA, S., DRAKE, J. R., WEBSTER, P., and MELLMAN, I. (1994). Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes. Nature 369, 113-120.
    • (1994) Nature , vol.369 , pp. 113-120
    • Amigorena, S.1    Drake, J.R.2    Webster, P.3    Mellman, I.4
  • 3
    • 0028863527 scopus 로고
    • Protection against mycoplasma infection using expression-library immunization
    • BARRY, M. A., LAI, W. C., and JOHNSON S. A. (1995). Protection against mycoplasma infection using expression-library immunization. Nature 377, 632-635.
    • (1995) Nature , vol.377 , pp. 632-635
    • Barry, M.A.1    Lai, W.C.2    Johnson, S.A.3
  • 5
    • 0031015971 scopus 로고    scopus 로고
    • Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus
    • BRUNA-ROMERO, O., LASARTE, J. J., WILKINSON, G., GRACE, K., CLARKE, B., BORRAS-CUESTA, F., and PRIETO, J. (1997). Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus. Hepatology 25, 470-477.
    • (1997) Hepatology , vol.25 , pp. 470-477
    • Bruna-Romero, O.1    Lasarte, J.J.2    Wilkinson, G.3    Grace, K.4    Clarke, B.5    Borras-Cuesta, F.6    Prieto, J.7
  • 6
    • 0028038280 scopus 로고
    • Sequence analysis of the core gene of 14 hepatitis C virus genotypes
    • BUKH, J., PURCELL, R. H., and MILLER, R. H. (1994). Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc. Natl. Acad. Sci. USA 91, 8239-8243.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8239-8243
    • Bukh, J.1    Purcell, R.H.2    Miller, R.H.3
  • 7
    • 0028970286 scopus 로고
    • Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
    • CASTELLINO, F., and GERMAIN, R. N. (1995). Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments. Immunity 2, 73-88.
    • (1995) Immunity , vol.2 , pp. 73-88
    • Castellino, F.1    Germain, R.N.2
  • 9
    • 0033555410 scopus 로고    scopus 로고
    • Identification of HLA-A3 and -B7 restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C
    • CHANG, K.-M., GRUENER, N. H., SOUTHWOOD, S., SIDNEY, J., PAPE, G. R., CHISARI, F. V., and SETTE, A. (1999). Identification of HLA-A3 and -B7 restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C. J. Immunol. 162, 1156-1164.
    • (1999) J. Immunol. , vol.162 , pp. 1156-1164
    • Chang, K.-M.1    Gruener, N.H.2    Southwood, S.3    Sidney, J.4    Pape, G.R.5    Chisari, F.V.6    Sette, A.7
  • 11
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • CHOO, QL. L., KUO, G., WEINER, A. J., OVERBY, L. R., BRADLEY, D. W., and HOUGHTON, M. (1989). Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359-362.
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 13
    • 0028018268 scopus 로고
    • The ubiquitin-proteosome proteolytic pathway
    • CIECHANOVER, A. (1994). The ubiquitin-proteosome proteolytic pathway. Cell 79, 13-21.
    • (1994) Cell , vol.79 , pp. 13-21
    • Ciechanover, A.1
  • 14
    • 0028872334 scopus 로고
    • Presentation of endogenous and exogenous antigens is not affected by inactivation of E1 ubiquitin-activating enzyme in temperature-sensitive cell lines
    • COX, J. H., GALARDY, P., BENNINK, J. R., and YEWDELL, J. W. (1995). Presentation of endogenous and exogenous antigens is not affected by inactivation of E1 ubiquitin-activating enzyme in temperature-sensitive cell lines. J. Immunol. 154, 511-519.
    • (1995) J. Immunol. , vol.154 , pp. 511-519
    • Cox, J.H.1    Galardy, P.2    Bennink, J.R.3    Yewdell, J.W.4
  • 16
    • 0024374199 scopus 로고
    • Murine cell lines stably expressing the influenza virus hemagglutinin gene introduced by a recombinant retrovirus vector are constitutive targets for MHC class I- And class II-restricted T lymphocytes
    • EAGER, K. B., HACKETT, C. J., GERHARD, W. U., BENNINK, J., EISENLOHR, L. C., YEWDELL, J. and RICCIARDI, R. (1989). Murine cell lines stably expressing the influenza virus hemagglutinin gene introduced by a recombinant retrovirus vector are constitutive targets for MHC class I- and class II-restricted T lymphocytes. J. Immunol. 143, 2328-2335.
    • (1989) J. Immunol. , vol.143 , pp. 2328-2335
    • Eager, K.B.1    Hackett, C.J.2    Gerhard, W.U.3    Bennink, J.4    Eisenlohr, L.C.5    Yewdell, J.6    Ricciardi, R.7
  • 18
    • 0032213351 scopus 로고    scopus 로고
    • Induction of MHC class I-restricted CTL response by DNA immunization with ubiquitin-influenza virus nucleoprotein fusion antigens
    • FU, T.-M., GUAN, L., FRIEDMAN, A., ULMER, J. B., LIU, M. A., and DONNELLY, J. J. (1998). Induction of MHC class I-restricted CTL response by DNA immunization with ubiquitin-influenza virus nucleoprotein fusion antigens. Vaccine 16, 1711-1717.
    • (1998) Vaccine , vol.16 , pp. 1711-1717
    • Fu, T.-M.1    Guan, L.2    Friedman, A.3    Ulmer, J.B.4    Liu, M.A.5    Donnelly, J.J.6
  • 19
    • 0031066827 scopus 로고    scopus 로고
    • Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids
    • GEISSLER, M., GESIEN, A., TOKUSHIGE, K., and WANDS, J. R. (1997a). Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids. J. Immunol. 158, 1231-1237.
    • (1997) J. Immunol. , vol.158 , pp. 1231-1237
    • Geissler, M.1    Gesien, A.2    Tokushige, K.3    Wands, J.R.4
  • 20
    • 0031808286 scopus 로고    scopus 로고
    • Cytokine and hepatitis B virus DNA coimmunizations enhance cellular and humoral immune responses to the middle but not to the large hepatitis B virus surface antigen in mice
    • GEISSLER, M., SCHIRMBECK, R., REIMANN, J., BLUM, H. E., and WANDS, J. R. (1998a). Cytokine and hepatitis B virus DNA coimmunizations enhance cellular and humoral immune responses to the middle but not to the large hepatitis B virus surface antigen in mice. Hepatology 28, 202-210.
    • (1998) Hepatology , vol.28 , pp. 202-210
    • Geissler, M.1    Schirmbeck, R.2    Reimann, J.3    Blum, H.E.4    Wands, J.R.5
  • 21
    • 0030904125 scopus 로고    scopus 로고
    • Cellular and humoral immune response to hepatitis B virus structural proteins in mice after DNA-based immunization
    • GEISSLER, M., TOKUSHIGE, K., CHANTE, C. C., ZURAWSKI, V. R., and WANDS, J. R. (1997b). Cellular and humoral immune response to hepatitis B virus structural proteins in mice after DNA-based immunization. Gastroenterology 112, 1307-1320.
    • (1997) Gastroenterology , vol.112 , pp. 1307-1320
    • Geissler, M.1    Tokushige, K.2    Chante, C.C.3    Zurawski, V.R.4    Wands, J.R.5
  • 22
    • 0032077308 scopus 로고    scopus 로고
    • Differential cellular and humoral immune responses to HCV core and HBV envelope proteins after genetic immunizations using chimeric constructs
    • GEISSLER, M., TOKUSHIGE, K., WAKITA, T., ZURAWSKI, V. R., and WANDS, J. R. (1998b). Differential cellular and humoral immune responses to HCV core and HBV envelope proteins after genetic immunizations using chimeric constructs. Vaccine 16, 857-867.
    • (1998) Vaccine , vol.16 , pp. 857-867
    • Geissler, M.1    Tokushige, K.2    Wakita, T.3    Zurawski, V.R.4    Wands, J.R.5
  • 23
    • 0030240571 scopus 로고    scopus 로고
    • Generation of naturally processed peptide/MHC class I complexes is independent of the stability of endogenously synthesized precursors
    • GOTH, S., NGUYEN, V., and SHASTRI, N. (1996). Generation of naturally processed peptide/MHC class I complexes is independent of the stability of endogenously synthesized precursors. J. Immunol. 157, 1894-1904.
    • (1996) J. Immunol. , vol.157 , pp. 1894-1904
    • Goth, S.1    Nguyen, V.2    Shastri, N.3
  • 24
    • 0027396163 scopus 로고
    • The motif Tyr-X-X-hydrophobic residue mediates lysosomal membrane targeting of lysosome-associated membrane protein 1
    • GUARNIERI, F. G., ARTERBURN, L. M., PENNO, M. B., CHA, Y., and AUGUST, J. T. (1993). The motif Tyr-X-X-hydrophobic residue mediates lysosomal membrane targeting of lysosome-associated membrane protein 1. J. Biol. Chem. 268, 1941-1946.
    • (1993) J. Biol. Chem. , vol.268 , pp. 1941-1946
    • Guarnieri, F.G.1    Arterburn, L.M.2    Penno, M.B.3    Cha, Y.4    August, J.T.5
  • 25
    • 0027370367 scopus 로고
    • Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment
    • HARDING, C. V., and GEUZE, H. (1993). Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment. J. Immunol. 151, 3988-3998.
    • (1993) J. Immunol. , vol.151 , pp. 3988-3998
    • Harding, C.V.1    Geuze, H.2
  • 26
    • 0026756119 scopus 로고
    • Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells
    • HARDING, C. V., and GEUZE, H. J. (1992). Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells. J. Immunol. 119, 531-542.
    • (1992) J. Immunol. , vol.119 , pp. 531-542
    • Harding, C.V.1    Geuze, H.J.2
  • 28
    • 0031050444 scopus 로고    scopus 로고
    • Plasmid DNA expressing a secreted or a nonsecreted form of hepatitis C virus nucleocapsid: Comparative studies of antibody and T-helper responses following genetic immunization
    • INCHAUSPÉ, G., VITVITSKI, L., MAJOR, M. E., JUNG, G., SPENGLER, U., MAISONNAS, M., and TRÉPO C. (1997). Plasmid DNA expressing a secreted or a nonsecreted form of hepatitis C virus nucleocapsid: comparative studies of antibody and T-helper responses following genetic immunization. DNA Cell Biol. 16, 182-195.
    • (1997) DNA Cell Biol. , vol.16 , pp. 182-195
    • Inchauspé, G.1    Vitvitski, L.2    Major, M.E.3    Jung, G.4    Spengler, U.5    Maisonnas, M.6    Trépo, C.7
  • 29
    • 0025787597 scopus 로고
    • Genomic structure of the human prototype strain H of hepatitis C virus: Comparison with American and Japanese isolates
    • INCHAUSPÉ, G., ZEBEDEE, S., LEE, D. H., SUGITANI, M., NASOFF, M., and PRICE, A. M. (1991). Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates. Proc. Natl. Acad. Sci. USA 88, 10292-10296.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 10292-10296
    • Inchauspé, G.1    Zebedee, S.2    Lee, D.H.3    Sugitani, M.4    Nasoff, M.5    Price, A.M.6
  • 31
    • 0029156764 scopus 로고
    • Immune responses to plasmid DNA encoding the hepatitis C virus core protein
    • LAGGING, L. M., MEYER, K., HOFT, D., HOUGHTON, M., BELSHE, R. B., and RAY, R. (1995). Immune responses to plasmid DNA encoding the hepatitis C virus core protein. J. Virol. 69, 5859-5863.
    • (1995) J. Virol. , vol.69 , pp. 5859-5863
    • Lagging, L.M.1    Meyer, K.2    Hoft, D.3    Houghton, M.4    Belshe, R.B.5    Ray, R.6
  • 32
    • 0025990592 scopus 로고
    • In vitro neutralisation of duck hepatitis B virus by antibodies specific to the N-terminal portion of pre-S protein
    • LAMBERT, V., CHASSOT, S., KAY, A., TRÉPO, C., and COVA L. (1991). In vitro neutralisation of duck hepatitis B virus by antibodies specific to the N-terminal portion of pre-S protein. Virology 185, 446-450.
    • (1991) Virology , vol.185 , pp. 446-450
    • Lambert, V.1    Chassot, S.2    Kay, A.3    Trépo, C.4    Cova, L.5
  • 33
    • 0033556262 scopus 로고    scopus 로고
    • Suppression of host immune response by the core protein of hepatitis C virus: Possible implications for hepatis C virus persistence
    • LARGE, M. K., KITTLESEN, D. J., and HAHN, Y. S. (1999). Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatis C virus persistence. J. Immunol. 162, 931-938.
    • (1999) J. Immunol. , vol.162 , pp. 931-938
    • Large, M.K.1    Kittlesen, D.J.2    Hahn, Y.S.3
  • 34
    • 0030068375 scopus 로고    scopus 로고
    • Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
    • LIN, K.-Y., GUARNIERI, F. G., STAVELEY-O'CARROLL, K. F., LEVITSKY, H. I., AUGUST, J. T., PARDOLL D. M., and WU, T.-C. (1996). Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res. 56, 21-26.
    • (1996) Cancer Res. , vol.56 , pp. 21-26
    • Lin, K.-Y.1    Guarnieri, F.G.2    Staveley-O'Carroll, K.F.3    Levitsky, H.I.4    August, J.T.5    Pardoll, D.M.6    Wu, T.-C.7
  • 35
    • 0027263157 scopus 로고
    • A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation
    • MICHALEK, M. T., GRANT, E. P., GRAMM, C., GOLDBERG, A. L., and ROCK, K. L. (1993). A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation. Nature 363, 552-554.
    • (1993) Nature , vol.363 , pp. 552-554
    • Michalek, M.T.1    Grant, E.P.2    Gramm, C.3    Goldberg, A.L.4    Rock, K.L.5
  • 36
    • 10244225383 scopus 로고    scopus 로고
    • Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
    • MISSALE, G., BERTONI, R., LAMONACA, V., VALLI, A., MASSARI, M., MORI, C., RUMI, M. G., HOUGHTON, M., FIACCADORI, F., and FERRARI C. (1996). Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J. Clin. Invest. 98, 706-714.
    • (1996) J. Clin. Invest. , vol.98 , pp. 706-714
    • Missale, G.1    Bertoni, R.2    Lamonaca, V.3    Valli, A.4    Massari, M.5    Mori, C.6    Rumi, M.G.7    Houghton, M.8    Fiaccadori, F.9    Ferrari, C.10
  • 37
    • 0030817934 scopus 로고    scopus 로고
    • Immunization with plasmid DNA encoding hepatitis C virus envelope E2 antigenic domains induces antibodies whose immune reactivity is linked to the injection mode
    • NAKANO, I., MAERTENS, G., MAJOR, M. E., VITVITSKI, L., DUBUISSON, J., FOURNILLIER, A., DE MARTYNOFF, G., TRÉPO, C., and INCHAUSPÉ, G. (1997). Immunization with plasmid DNA encoding hepatitis C virus envelope E2 antigenic domains induces antibodies whose immune reactivity is linked to the injection mode. J. Virol. 71, 7101-7109.
    • (1997) J. Virol. , vol.71 , pp. 7101-7109
    • Nakano, I.1    Maertens, G.2    Major, M.E.3    Vitvitski, L.4    Dubuisson, J.5    Fournillier, A.6    De Martynoff, G.7    Trépo, C.8    Inchauspé, G.9
  • 38
    • 0025954714 scopus 로고
    • Identification of an immunodominant epitope within the capsid protein of hepatitis C virus
    • NASOFF, M. S., ZEBEDEE, S. L., INCHAUSPÉ, G., and PRINCE, A. M. (1991). Identification of an immunodominant epitope within the capsid protein of hepatitis C virus. Proc. Natl. Acad. Sci. USA 88, 5462-5466.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5462-5466
    • Nasoff, M.S.1    Zebedee, S.L.2    Inchauspé, G.3    Prince, A.M.4
  • 40
    • 0028285075 scopus 로고
    • Separation of subcellular compartments containing distinct functional forms of MHC class II
    • QIU, Y., XU, X., WANDINGER-NESS, A., DALKE, D. P., and PIERCE, S. K. (1994). Separation of subcellular compartments containing distinct functional forms of MHC class II. J. Cell. Biol. 125, 595-605.
    • (1994) J. Cell. Biol. , vol.125 , pp. 595-605
    • Qiu, Y.1    Xu, X.2    Wandinger-Ness, A.3    Dalke, D.P.4    Pierce, S.K.5
  • 41
    • 0029792293 scopus 로고    scopus 로고
    • Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients
    • REHERMANN, B., CHANG, K.-M., McHUTCHINSON, J., KOKKA, R., HOUGHTON, M., RICE, C. M., and CHISARI, F. V. (1996). Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients. J. Virol. 70, 7092-7102.
    • (1996) J. Virol. , vol.70 , pp. 7092-7102
    • Rehermann, B.1    Chang, K.-M.2    McHutchinson, J.3    Kokka, R.4    Houghton, M.5    Rice, C.M.6    Chisari, F.V.7
  • 42
    • 0030812840 scopus 로고    scopus 로고
    • DNA immunization: Ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction
    • RODRIGUEZ, F., ZHANG, J., and WHITTON, J. L. (1997). DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. J. Virol. 71, 8497-8503.
    • (1997) J. Virol. , vol.71 , pp. 8497-8503
    • Rodriguez, F.1    Zhang, J.2    Whitton, J.L.3
  • 43
    • 0029044133 scopus 로고
    • Endocytosis of endogenously synthesized HIV-1 envelope protein: Mechanism and role in processing for association with class II MHC
    • ROWELL, J. F., STANHOPE, P. E., and SILICIANO, R. F. (1995). Endocytosis of endogenously synthesized HIV-1 envelope protein: mechanism and role in processing for association with class II MHC. J. Immunol. 155, 473-488.
    • (1995) J. Immunol. , vol.155 , pp. 473-488
    • Rowell, J.F.1    Stanhope, P.E.2    Siliciano, R.F.3
  • 44
    • 0030929333 scopus 로고    scopus 로고
    • The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway
    • RUFF, A. L., GUARNIERI, F. G., STAVELEY-O'CARROLL, K., SILICIANO, R. F., and AUGUST, J. T. (1997). The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway. J. Biol. Chem. 272, 8671-8678.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8671-8678
    • Ruff, A.L.1    Guarnieri, F.G.2    Staveley-O'Carroll, K.3    Siliciano, R.F.4    August, J.T.5
  • 47
    • 19144371869 scopus 로고
    • Simple fluorescent enzyme immunoassay for detection and quantification of hepatitis C viremia
    • TANAKA, T., LAU, I. Y. N., MIZOKAMI, M., ORITO, E., TANAKA, E., KIYOSAWA, K., and YASUI, K. (1995). Simple fluorescent enzyme immunoassay for detection and quantification of hepatitis C viremia. J. Hepatol. 23, 742-745.
    • (1995) J. Hepatol. , vol.23 , pp. 742-745
    • Tanaka, T.1    Lau, I.Y.N.2    Mizokami, M.3    Orito, E.4    Tanaka, E.5    Kiyosawa, K.6    Yasui, K.7
  • 48
    • 0033555390 scopus 로고    scopus 로고
    • Induction of enhanced CTL-dependent protective immunity in vivo by N-end rule targeting of a model tumor antigen
    • TOBERY, T., and SILICIANO, R. F. (1999). Induction of enhanced CTL-dependent protective immunity in vivo by N-end rule targeting of a model tumor antigen. J. Immunol. 162, 639-642.
    • (1999) J. Immunol. , vol.162 , pp. 639-642
    • Tobery, T.1    Siliciano, R.F.2
  • 49
    • 0030977234 scopus 로고    scopus 로고
    • Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization
    • TOBERY, T. W., and SILICIANO R. F. (1997). Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization. J. Exp. Med. 185, 909-920.
    • (1997) J. Exp. Med. , vol.185 , pp. 909-920
    • Tobery, T.W.1    Siliciano, R.F.2
  • 51
    • 0029861143 scopus 로고    scopus 로고
    • The N-end rule: Functions, mysteries, uses
    • VARSHAVSKY, A. (1996). The N-end rule: functions, mysteries, uses. Proc. Natl. Acad. Sci. USA 93, 12142-12149.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12142-12149
    • Varshavsky, A.1
  • 52
    • 0030997067 scopus 로고    scopus 로고
    • Regulating protein degradation by ubiquitination
    • WEISSMAN, A. M. (1997). Regulating protein degradation by ubiquitination. Immunol. Today 18, 189-198.
    • (1997) Immunol. Today , vol.18 , pp. 189-198
    • Weissman, A.M.1
  • 54
    • 0031573585 scopus 로고    scopus 로고
    • Deoxyribonucleoic acid vaccines encoding antigens with rapid proteasome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes
    • WU, Y. and KIPPS, T. J. (1997). Deoxyribonucleoic acid vaccines encoding antigens with rapid proteasome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes. J. Immunol. 159, 6037-6043.
    • (1997) J. Immunol. , vol.159 , pp. 6037-6043
    • Wu, Y.1    Kipps, T.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.