Intranasal administration of human immunodeficiency virus type-1 (HIV- 1) DNA vaccine with interleukin-2 expression plasmid enhances cell-mediated immunity against HIV-1

Immunology

Volumn 94, Issue 3, 1998, Pages 438-444

  Xin, K Q ^a   Hamajima, K ^a   Sasaki, S ^a   Honsho, A ^a   Tsuji, T ^a   Ishii, N ^a   Cao, X R ^a   Lu, Y ^a   Fukushima, J ^a   Shapshak, P ^b   Kawamoto, S ^a   Okuda, K ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERLEUKIN 2;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CELLULAR IMMUNITY; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; INTRANASAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; FECES; FEMALE; HIV INFECTIONS; HIV-1; IMMUNITY, CELLULAR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; PLASMIDS; VACCINES, DNA;

EID: 15144348897     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00533.x     Document Type: Article

References (28)

1. BUKAWA H., SEKIGAWA K., HAMAJIMA K. et al. (1995) Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate. Nat Med 1, 681.
2. OKUDA K., BUKAWA H., HAMAJIMA K. et al. (1995) Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products. AIDS Res Hum Retrov 11, 933.
3. CARMICHAEL A., JIN X., SISSONS P. & BORYSIEWICS L. (1993) Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1) -specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential (CTL) responses to HIV-1 and Epstein-Barr virus in late disease. J Exp Med 177, 246.
4. THAN S., HU R., OYAIZU N. et al. (1997) Cytokine pattern in relation to disease progression in human immunodeficiency virus-infected children. J Infect Dis 175, 47.
5. CARSON W.E., GIRI J.G., LINDENMANN M.J. et al. (1994) Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180, 1395.
6. MALIM M.H., HAUBER J., FENRICK R. & CULLEN B.R. (1988) Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. Nature 335, 181.
7. KARASUYAMA H., TOHYAMA N. & TADA T. (1989) Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J Exp Med 169, 13.
8. ISHII N., FUKUSHIMA J., KANEKO T. et al. (1997) Cationic liposomes are a strong adjuvant for a human immunodeficiency virus type-I (HIV-1) vaccine candidate constructed with HIV-1 env and rev genes. AIDS Res Hum Retrov 13, 1421.
9. OKADA E., SASAKI S., ISHII N, et al (1997) Intranasal immunization of a DNA vaccine with IL-12 and granulocyte-macrophage colony-stimulating factor (GM-CSF) -expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens. J Immunol 159, 3638.
10. TSUJI T., HAMAJIMA K., FUKUSHIMA J. et al. (1997) Enhancement of cell-mediated immunity against HIV-1 induced by coinoculation of plasmid-cncodcd HIV-1 antigen with plasmid expressing interleukin-12. J Immunol 158, 4008.
11. OKUDA K., MINAMI M., JU S.T. & DORF M.E. (1981) Functional association of idiotypic and I-J determinants on the antigen receptor of suppressor T cells. Proc Natl Acad Sci USA 78, 4557.
12. LAYTON G.T., HARRIS S.J., GEARING A.J. et al. (1993) Induction of HIV-specific cytotoxic T lymphocytes in vivo with hybrid HIV-1, V3; Ty-virus-like particles. J Immunol 151, 1097.
13. TAKAHASHI H., GFRMAIN R.N., MOSS B. & BERZOFSKY, J.A. (1990) An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 II-restricted help for itself. J Exp Med 171, 571.
14. SATO Y., ROMAN M., TIGHE H. et al. (1996) Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273, 352.
15. FYNAN E.F., WEBSTER R., FULLER D., HAYNES J., SANTORO J. & ROBINSON H. (1995) DNA vaccines: a novel approach to immunization. Int J Immunopharmacol 17, 79.
16. + cell clones derived from HIV-infected and uninfected individuals. Celt Immunol 159, 271.
17. CLERICI M., GIOROI J.V., CHOU C.-C. et al (1992) Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV. J Infect Dix 165, 1012.
18. WOLFF J.A., MALONE W., WILLIAMS P. et al. (1990) Direct gene transfer into mouse muscle in vivo. Science 247, 1465.
19. TRINCHIERI G. (1994) Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84, 4008.
20. KOVACS J.A., BASELER M., DEWAR R.J. et al. (1995) Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. N Engl J Med 332, 567.
21. FAN J., BASS H.Z. & FAHEY J.L. (1993) Elevated IFN-γ and decreased IL-2 gene expression are associated with HIV infection. J Immunol 151, 5031.
22. TANIGUCHI T. & MINAMI Y. (1993) The IL-2/IL-2 receptor system: a current overview. Cell 73, 5.
23. ADACHI Y., OYAIZU N., THAM S., MCCLOSKEY T.W. & PAHWA S. (1996) IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection. J Immunol 157, 4184.
24. PRAYAGA S.K., FORD M.J. & HAYNES J.R. (1997) Manipulation of HIV-1 gp120-specific immune responses elicited via gene gun-based DNA immunization. Vaccine 15, 1349.
25. RUBY J., BRINKMAN C., JONES S. & RAMSHAW I. (1990) Response of monkeys to vaccination with recombinant vaccinia virus which coexpress HIV gp160 and human interleukin-2. Immunol Cell Biol 68, 113.
26. KINTER A.L., POLI G., FOX L., HARDY E. & FAUCI A.S. (1995) HIV replication in IL-2-stimulated peripheral blood mononuclcar cells is driven in an autocrine/paracrine manner by endogenous cytokines. J Immunol 154, 2448.
27. KOVACS J.A., VOGEL S., ALBERT J.M. et al. (1996) Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N Engl J Med 335, 1350.
28. JACOBSON E.L., PILARO F. & SMITH K.A. (1996) Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity. Proc Natl Acad Sci USA 93, 10405.