Alphavirus expression vectors and their use as recombinant vaccines: A minireview

Gene

Volumn 190, Issue 1, 1997, Pages 191-195

  Tubulekas, Ioannis ^a   Berglund, Peter ^a   Fleeton, Marina ^a   Liljeström, Peter ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Helper vector; Nucleic acid vaccine; Self replicating RNA; Semliki Forest virus; Togaviruses; Transfection

Indexed keywords

DNA; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INFLUENZA VACCINE; RECOMBINANT VACCINE; RNA;

ALPHA VIRUS; CELLULAR IMMUNITY; CONFERENCE PAPER; DNA SEQUENCE; EXPRESSION VECTOR; GENE TARGETING; GENETIC TRANSFECTION; HUMORAL IMMUNITY; IMMUNOLOGICAL MEMORY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RNA SEQUENCE; VIRUS PARTICLE;

ALPHAVIRUS; GENETIC VECTORS; NUCLEIC ACIDS; VACCINES, SYNTHETIC;

EID: 0030917931     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(96)00679-8     Document Type: Conference Paper

References (32)

1. Berglund, P., Sjöberg, M., Atkins, G.J., Sheahan, B.J., Garoff, H. and Liljeström, P. (1993) Semliki Forest virus expression system: production of conditionally infectious recombinant particles. Bio/Technology 11, 916-920.
2. Berglund, P., Tubulekas, I. and Liljeström, P. (1996) Alphaviruses as vectors for gene delivery. Trends Biotechnol. 14, 130-134.
3. Bredenbeek, P.J. and Rice, C.M. (1992) Animal RNA virus expression systems. Semin. Virol. 3, 297-310.
4. Bredenbeek, P.J., Frolov, I., Rice, C.M. and Schlesinger, S. (1993) Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs. J. Virol. 67, 6439-6446.
5. Davis, N.L., Willis, L.V., Smith, J.F. and Johnston, R.E. (1989) In vitro synthesis of infectious Venezuelan equine encephalitis virus RNA from a cDNA clone: analysis of a viable deletion mutant. Virology 171, 189-204.
6. Dubensky, T.W., Driver, D.A., Polo, J.M., Belli, B.A., Latham, E.M., Ibanez, C.E., Chada, S., Brumm, D., Banks, T.A., Mento, S.J., Jolly, D.J. and Chang, S.M.W. (1996) Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer. J. Virol. 70, 508-519.
7. Frolov, I. and Schlesinger, S. (1994) Translation of Sindbis virus mRNA - effects of sequences downstream of the initiating codon. J. Virol. 68, 8111-8117.
8. Frolov, Y. and Schlesinger, S. (1996) Translation of Sindbis virus mRNA: analysis of sequences downstream of the initiating AUG codon that enhance translation. J. Virol. 70, 1182-1190.
9. Hahn, C.S., Hahn, Y.S., Braciale, T.J. and Rice, C.M. (1992) Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation. Proc. Natl. Acad. Sci. USA 89, 2679-2683.
10. Herweijer, H., Latendresse, J.S., Williams, P., Zhang, G.F., Danko, I., Schlesinger, S. and Wolff, J.A. (1995) A plasmid-based self-amplifying Sindbis virus vector. Hum. Gene Ther. 6, 1161-1167.
11. Johanning, F.W., Conry, R.M., Lobuglio, A.F., Wright, M., Sumerel, L.A., Pike, M.J. and Curiel, D.T. (1995) A Sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expression in vivo. Nucleic Acids Res. 23, 1495-1501.
12. Kinney, R.M., Chang, G.-J., Tsuchiya, K.R., Sneider, J.M., Roehrig, J.T., Woodward, T.M. and Trent, D.W. (1993) Attenuation of Venezuelan equine encephalitis virus strain TC-83 is encoded by the 5′-noncoding region and the E2 envelope glycoprotein. J. Virol. 67, 1269-1277.
13. Kuhn, R.J., Niesters, H.G.M., Hong, Z. and Strauss, J.H. (1991) Infectious RNA transcripts from Ross River virus cDNA clones and the construction and characterization of defined chimeras with Sindbis virus. Virology 182, 430-441.
14. Liljeström, P. (1994) Alphavirus expression systems. Curr. Opin. Biotechnol. 5, 495-500.
15. Liljeström, P. (1995) Recombinant self-replicating RNA vaccines. In: Gregoriadis, G., McCormack, B. and Allison, A.C. (Eds.), Vaccines: New-Generation Immunological Adjuvants, Vol. 282. Plenum Press, New York, NY, 173-180.
16. Liljeström, P. and Garoff, H. (1991) A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. Bio/ Technology 9, 1356-1361.
17. Liljeström, P. and Garoff, H. (1994) Expression of proteins using Semliki Forest virus vectors. In: Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Smith, J.A., Seidman, J.G. and Struhl, K. (Eds.), Current Protocols in Molecular Biology. Greene Publishing Associates and Wiley Interscience, New York, NY, pp. 16.20.1-16.20.16.
18. Liljeström, P., Lusa, S., Huylebroeck, D. and Garoff, H. (1991) In vitro mutagenesis of a full-length cDNA clone of Semliki Forest virus: the 6,000-molecular-weight membrane protein modulates virus release. J. Virol. 65, 4107-4113.
19. London, S.D., Schmaljohn, A.L., Dalrymple, J.M. and Rice, C.M. (1992) Infectious enveloped RNA virus antigenic chimeras. Proc. Natl. Acad. Sci. USA 89, 207-211.
20. Mossman, S., Bex, F., Berglund, P., Arthos, J., O'Neil, S.P., Riley, D., Maul, D.H., Bruck, C., Momin, P., Burny, A., Fultz, P.N., Mullins, J.I., Liljeström, P. and Hoover, E.A. (1996) Protection against lethal SIVsmmPBj14 disease by a recombinant Semliki Forest virus gp160 vaccine and by gp120 subunit vaccine. J. Virol. 70, 1953-1960.
21. Olkkonen, V.M., Dupree, P., Simons, K., Liljeström, P. and Garoff, H. (1994) Expression of exogenous proteins in mammalian cells with the Semliki Forest virus vector. Methods Cell Biol. 43, 43-53.
22. Piper, R.C., Slot, J.W., Li, G.P., Stahl, P.D. and James, D.E. (1994) Recombinant Sindbis virus as an expression system for cell biology. Methods Cell Biol. 43, 55-78.
23. Raju, R., Subramaniam, S.V. and Hajjou, M. (1995) Genesis of Sindbis virus by in vivo recombination of nonreplicative RNA precursors. J. Virol. 69, 7391-7401.
24. Rice, C.M., Levis, R., Strauss, J.H. and Huang, H.V. (1987) Production of infectious RNA transcripts from Sindbis virus cDNA clones: mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants. J. Virol. 61, 3809-3819.
25. Salminen, A., Wahlberg, J.M., Lobigs, M., Liljeström, P. and Garoff, H. (1992) Membrane fusion process of Semliki Forest virus II: cleavage dependent reorganization of the spike protein complex controls virus entry. J. Cell Biol. 116, 349-357.
26. Schlesinger, S. (1993) Alphaviruses - vectors for the expression of heterologous genes. Trends Biotechnol. 11, 18-22.
27. Sjöberg, E.M., Suomalainen, M. and Garoff, H. (1994) A significantly improved Semliki Forest virus expression system based on translation enhancer segments from the viral capsid gene. Bio/Technology 12, 1127-1131.
28. Strauss, J.H. and Strauss, E.G. (1994) The alphaviruses: gene expression, replication, and evolution. Microbiol. Rev. 58, 491-562.
29. Weiss, B.G. and Schlesinger, S. (1991) Recombination between Sindbis virus RNAs. J. Virol. 65, 4017-4025.
30. Xiong, C., Levis, R., Shen, P., Schlesinger, S., Rice, C.M. and Huang, H.V. (1989) Sindbis virus: an efficient, broad host range vector for gene expression in animal cells. Science 243, 1188-1191.
31. Zhou, X., Berglund, P., Rhodes, G., Parker, S.E., Jondal, M. and Liljeström, P. (1994) Self-replicating Semliki Forest virus RNA as recombinant vaccine. Vaccine 12, 1510-1514.
32. Zhou, X., Berglund, P., Zhao, H., Liljeström, P. and Jondal, M. (1995) Generation of cytotoxic and humoral immune responses by non-replicative recombinant Semliki Forest virus. Proc. Natl. Acad. Sci. USA 92, 3009-3013.