Microspheres containing plasmid-encoded antigens elicit cytotoxic T- cell responses

Nature Medicine

Volumn 4, Issue 3, 1998, Pages 365-368

  Hedley, Mary Lynne ^a   Curley, Joanne ^b,c   Urban, Robert ^a  

^a Pangaea Pharmaceuticals Inc   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c Department of Life Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; MICROSPHERE; PLASMID DNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PLASMID; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS; CYTOTOXICITY, IMMUNOLOGIC; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; IMMUNIZATION; LACTIC ACID; LUCIFERASES; MICE; MICROSPHERES; PARTICLE SIZE; PHAGOCYTOSIS; PLASMIDS; POLYGLYCOLIC ACID; POLYMERS; T-LYMPHOCYTES, CYTOTOXIC;

ANIMALIA;

EID: 0031915963     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0398-365     Document Type: Article

References (12)

1. ParclollH, D. & Beckerieg, A.M. Exposing the immunology of naked DNA vaccines. Immunity 3, 165-169 (1995).
2. McDonnell, W.M. & Askari, F.K. DNA vaccines. New Engl. J. Med. 334, 42-45 (1996).
3. Corr, M., Lee, D.J., Carson, D.A. & Tighe, H. +Gene vaccination with naked plasmid DNA: Mechanism of CTL priming. J. Exp. Med. 184, 1555-1560 (1996).
4. Doe, B., Selby, M., Barnett, S., Baenziger, J. & Walker, C. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow derived cells. Proc. Natl. Acad. Scei. USA 93, 8578-8583 (1996).
5. Iwasaki, A., Torres, CAT., Ohashi, P.S., Robinson, H.L & Barber, B.H.J. The dominant role of bone marrow derived cells in CTL induction following plasmid DNA immunization at different sites. Immunology 159, 11-14 (1997).
6. Okada, H. & Toguchi, H. Biodegradable microspheres in drug delivery. Crit. Rev. Ther. Drug Carrier Sys. 12, 1-99 (1995).
7. Tabata, Y. & Ikada, Y. Phagocytosis of polymer microspheres by macrophages. Adv. Polymer Sci. 94, 107-141 (1990).
8. Kanke, M. Geissler, R.C., Powell, D., Kaplan, A. & DeLuca, P.P.J. Interaction of microspheres with blood constituents. III. Macrophage phagocytosis of various types of polymeric drug carriers. Parenteral Sci. Technol. 42, 157-165 (1988).
9. Carbone, F.R. & Bevan, M.J. Induction of oval bum in-specific cytotoxic T cells by in vivo peptide immunization. J. Exp. Med. 169, 603-612 (1989).
10. Vitiello, A., et al. Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. J. Clin. Invest. 95, 341-349 (1995).
11. Fayolle, C., et al. Induction of cytotoxic T-cell response by optimal length peptides does not require CD4+ T-cell help. Immunology 89, 41-45 (1996).
12. Anton, L.C., Yewdall, J.W. SE Bennink, J.R. MHC-class I associated peptides produced from endogenous gene products with vastly different efficiencies. J. Immunol. 158, 2535-2542 (1997).