DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

Vaccine

Volumn 16, Issue 19, 1998, Pages 1818-1821

  Ugen, Kenneth E ^a   Nyland, Susan B ^a   Boyer, Jean D ^b   Vidal, Cristina ^a   Lera, Liana ^a   Rasheid, Sowsan ^a   Chattergoon, Michael ^b   Bagarazzi, Mark L ^c   Ciccarelli, Richard ^d   Higgins, Terry ^d   Baine, Yaila ^d   Ginsberg, Richard ^d   Macgregor, Rob Roy ^b   Weiner, David B ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d Apollon Inc   (United States)

Author keywords

Antibody; DNA plasmid vaccination; ELISA

Indexed keywords

DNA; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELLULAR IMMUNITY; CHIMPANZEE; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOTHERAPY; NONHUMAN; PLASMID; PRIORITY JOURNAL; VACCINATION; VIRUS GENE; VIRUS LOAD;

AIDS VACCINES; AMINO ACID SEQUENCE; ANTIBODY FORMATION; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; PLASMIDS; VACCINES, DNA;

EID: 0032210747     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00180-7     Document Type: Conference Paper

References (10)

1. 1 Desrosiers, R. C. Safety issues facing development of a live-attenuated, multiply deleted HIV-1 vaccine. AIDS Res. Human Retroviruses 1994, 10, 331-332.
2. 2 Kampinga, G. A., Simonon, A., Van De Perre, P., Karita, E., Msellati, P. and Goudsmit, J. Findings of heterogeneity at seroconversion, coinfection, and recombinants of HIV-1 subtypes A and C. Virology 1997, 227, 63-76.
3. 3 Boyer, J. D., Ugen K. E., Chattergoon M., et al. DNA vaccination as anti-HIV immunotherapy in infected chimpanzees. J. Infect. Dis., 1997, 176, 1501-1509.
4. 4 Boyer, J. D., Ugen, K. E. and Wang, B. et al. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nature Med. 1997, 3, 526-532.
5. 5 Boyer, J. D., Wang, B. and Srikantan, V. et al. Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in non-human primates by in vivo DNA inoculation. Virology 1995, 211, 102-112.
6. 6 Ugen, K. E., Boyer, J. D. and Wang, B. et al. Nucleic acid immunization of chimpanzees prophylactic/immunotherapeutic vaccination model for HIV-1: prelude to a clinical trial. Vaccine 1997, 15, 927-930.
7. 7 Wang, B., Boyer, J. and Srikantan, V. et al. DNA inoculation induces neutralizing immune responses against human immunodeficiency virus type 1 in mice and non-human primates. DNA Cell Biol. 1993, 12, 799-805.
8. 8 Wang, B., Ugen, K. E. and Srikantan, V. et al. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 4156-4160.
9. 9 Ugen, K. E., Goedert, J. J. and Boyer, J. et al. Vertical transmission of human immunodeficiency virus (HIV) infection. Reactivity of maternal sera with glycoprotein 120 and 41 peptides from HIV type 1. J. Clin. Invest. 1992, 89, 1923-1930.
10. 10 Ugen, K. E., Srikantan, V., Goedert, J. J., Nelson, R. P., Williams, W. V. and Weiner, D. B. Vertical transmission of immunodeficiency virus type 1: seroreactivity by maternal antibodies to the carboxy region of the gp41 envelope. J. Infect. Dis. 1997, 175, 63-69.