Enhancement of protective humoral (Th2) and cell-mediated (Th1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte-macrophage colony-stimulating factor expression cassettes

European Journal of Immunology

Volumn 28, Issue 11, 1998, Pages 3530-3540

  Sin, Jeong Im ^a   Kim, Jong J ^a   Ugen, Kenneth E ^b   Ciccarelli, Richard B ^c   Higgins, Terry J ^c   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c WLVP   (United States)

Author keywords

DNA vaccine; Granulocyte macrophage colony stimulating factor; Herpes simplex virus infection; Immune response

Indexed keywords

ADJUVANT; COMPLEMENTARY DNA; DNA VACCINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HERPES VACCINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; FEMALE; HELPER CELL; HERPES; HERPES SIMPLEX VIRUS 2; HUMORAL IMMUNITY; INTRAMUSCULAR DRUG ADMINISTRATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL;

ANIMALS; ANTIBODY FORMATION; CYTOKINES; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; TH1 CELLS; TH2 CELLS; VACCINES, DNA; VIRAL ENVELOPE PROTEINS; VIRAL VACCINES;

EID: 0031768522     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199811)28:11<3530::AID-IMMU3530>3.0.CO;2-C     Document Type: Article

References (42)

1. Wang, B., Ugen, K. E., Srikantan, V., Agadjanyan, M. G., Dang, K., Refaeli, Y., Sato, A., Boyer, J., Williams, W. V. and Weiner, D. B., Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 1993. 90: 4156-4160.
2. Wang, B., Boyer, J. D., Srikantan, V., Coney, L., Carrano, R., Phan, C., Merva, M., Dang, K., Agadjanyan, M. G., Ugen, K. E., Williams, W. V. and Weiner, D. B., DNA inoculation induces neutralizing immune responses against human immunodeficiency virus type 1 in mice and non-human primates. DNA Cell Biol. 1993. 12: 799-805.
3. Kuhober, A., Pudollek, H.-P., Reifenberg, K., Chisari, F. V., Schlicht, H.-J., Reimann, J. and Schirmbeck, R., DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice. J. Immunol. 1996. 156: 3687-3695.
4. Major, M. E., Vitvitski, L., Mink, M. A., Schleef, M., Whalen, R. G., Trepo, C. and Inchauspe, G., DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid. J. Virol. 1995. 69: 5798-5805.
5. Lagging, L. M., Meyer, K., Hoft, D., Houghton, M., Belshe, R. B. and Ray, R., Immune responses to plasmid DNA encoding the hepatitis C virus core protein. J. Virol. 1995. 69: 5859-5863.
6. Ulmer, J. B., Donnelly, J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V. L., Gromkowki, S. H., Deck, R., DeVitt, C. M., Friedman, A., Hawe, L. A., Leander, K. R., Marinez, D., Perry, H., Shiver, J. W., Montgomery, D. and Liu, M. A., Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993. 259: 1745-1749.
7. Xiang, Z. Q., Spitalnik, S., Tran, M., Wunner, W. H., Cheng, J. and Ertl, H. C. J., Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 1994. 199: 132-140.
8. Kriesel, J. D., Spruance, S. L., Daynes, R. A. and Araneo, B. A., Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease. J. Infect. Dis. 1996. 173: 536-541.
9. Bourne, N., Stanberry, L. R., Bernstein, D. I. and Lew, D., DNA immunization against experimental genital herpes simplex virus infection. J. Infect. Dis. 1996. 173: 800-807.
10. Sin, J. I., Sung, J. H., Suh, Y. S., Lee, A. H., Chung, J. H. and Sung, Y. C., Protective immunity against heterologous challenge with encephalomyocarditis virus by VP1 DNA vaccination: effect of co-injection with a granulocyte, macrophage-colony stimulating factor gene. Vaccine 1997. 15: 1827-1833.
11. Levy, M. Y., Barron, L. G., Meyer, K. B. and Szoka, Jr. F. C., Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther. 1996. 3: 201-211.
12. Wells, D. J., Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle. FEBS lett. 1993. 332: 179-182.
13. Chattergoon, M., Boyer, J. and Weiner, D. B., Genetic immunization: a new era in vaccines and immune therapies. FASEB J. 1997. 11: 753-763.
14. Condon, C., Watkins, S., Celluzzi, C., Thompson, K. and Faldo, L., DNA-based immunization by in vivo transfection of dendritic cells. Nature Med. 1996. 2: 1122-1128.
15. Chattergoon, M. A., Robinson, T. M., Boyer, J. D. and Weiner, D. B., Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages. J. Immunol. 1998. 160: 5707-5718.
16. Nahmias, A. J., Dannenberger, J., Wickliffe, C. and Muther, J. (Eds.) Clinical aspects of infection with herpes simplex virus 1 and 2. Elsevier Press, New York 1980.
17. Long, D., Madara, T.J., de Leon, M.P., Cohen, G.H., Montgomery, P.C. and Eisenberg, R. J., Glycoprotein D protects mice against lethal challenge with herpes simplex virus types 1 and 2. Infect. Immun. 1984. 43: 761-764.
18. Nicola, A. V., Willis, S. H., Naidoo, N. N., Rosenberg, R. J. and Cohen, G. H., Structure-function analysis of soluble forms of herpes simplex virus glycoprotein D. J. Virol. 1996. 70: 3815-3822.
19. Rager-Zisman, B. and Allison, A. C., Mechanism of immunologic resistance to herpes simplex virus (HSV-1) infection. J. Immunol. 1976. 116: 35-40.
20. Notkins, A. L., Immune mechanisms by which the spread of viral infections is stopped. Cell. Immunol. 1974. 11: 478-483.
21. Kohl, S., Starr, S. E., Oleske, J. M., Shore, S. L., Ashman, R. B. and Nahmias, A. J., Human monocyte-macrophage-mediated antibody dependent cytotoxicity to herpes simplex virus-infected cells. J. Immunol. 1977. 118: 729-735.
22. Shore, S. L., Cromeans, T. L. and Norrild, B., Early damage of herpes infected cells by antibody-dependent cellular cytotoxicity: Relative roles of virus-specific cell surface antigens and input virus. J. Immunol. 1979. 123: 2239-2244.
23. Norrild, B., Shore, S. L. and Nahmias, A. J., Herpes simplex virus glycoproteins: Participation of individual herpes simplex virus type 1 glycoprotein antigens in immunocytosis and their correlation with previously identified glycopolypeptides. J. Virol. 1979. 32: 741-748.
24. Sethi, K. K., Omata, Y. and Schneweis, K. E., Protection of mice from lethal herpes simplex virus type 1 infection by adoptive transfer of cloned virus-specific and H-2-restricted cytotoxic T lymphocytes. J. Gen. Virol 1983. 64: 443-447.
25. Zinkernagel, R. M. and Althage, A., Antiviral protection by virus-immune cytotoxic T cells; Infected target cells are lysed before infectious virus progeny is assembled. J. Exp. Med. 1977. 145: 644-651.
26. Zinkernagel, R. M. and Doherty, P. C., MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv. Immunol. 1979. 27: 52-177.
27. Straus, S. E., Wald, A., Kost, R. G., McKenzie, R., Langenberg, A. G., Hohman, P., Lekstrom, J., Cox, E., Nakamura, M., Sekulovich, R., Izu, A., Dekker, C. and Corey, L., Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: results of a placebo-controlled vaccine trial. J. Infect. Dis. 1997. 176: 1129-1134.
28. Xiang, Z. and Ertl, H. C., Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 1995. 2: 129-135.
29. Price, R. W., Walz, M. A., Wohlenberg, C. and Notkins, A. L., Latent infection of sensory ganglia with herpes simplex virus: efficacy of immunization. Science 1975. 188: 938-940.
30. Hamilton, J. A., Colony stimulating factors, cytokines and monocyte-macrophages-some controversies. Immunol. Today 1993. 14: 18-24.
31. Moore, M. A. S., The clinical use of colony stimulating factors. Annu. Rev. Immunol. 1991. 9: 159-191.
32. Hewitt, R. G., Morse, G. D., Lawrence, W. D., Maliszewski, M. L., Santora, J., Bartos, L. Bonnem, E. and Poiesz, B., Pharmacokinetics and pharmacodynamics of granulocyte-macrophage colony stimulating factor and zidovudine in patients with AIDS and severe AIDS-related complex. Antimicrob. Agents Chemother. 1993. 37: 512-522.
33. Kim, J. J., Ayyavoo, V., Bagarazzi, M. L., Chattergoon, M. A., Dang, K., Wang, B., Boyer, J. D. and Weiner, D. B., In vivo engineering of a cellular immune response by co-administration of IL-12 expression vector with a DNA immunogen. J. Immunol. 1997. 158: 816-826.
34. Kim, J. J., Trivedi, N. N., Nottingham, L., Morrison, L., Tsai, A., Hu, Y., Mahalingam, S., Dang, K., Ahn, L., Doyle, N. K., Wilson, D. M., Chattergoon, M. A., Chalian, A. A., Boyer, J. D., Agadjanyan, M. G. and Weiner, D. B., Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. Eur. J. Immunol. 1998. 28: 1089-1103.
35. Coffman, R. L., Seymour, B. W. P., Lebman, D. A., Hiraki, D. D., Christiansen, J. A., Shrader, B., Cherwinski, H. M., Savelkoul, H. F. J., Finkelman, F. D., Bond, M. W. and Mosmann, T. R., The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 1988. 102: 5-28.
36. Finkelman, F. D., Holmes, J., Katona, I. M., Urban, J. R, Beckmann, M. P., Park, L. S., Schooley, K. A., Coffman, R. L., Mosmann, T. R. and Paul, W. E., Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 1990. 8: 303-333.
37. Eis-Hubinger, A. M., Schmidt, D. S. and Schneweis, K. E., Anti-glycoprotein B monoclonal antibody protects T cell depleted mice against herpes simplex virus by inhibition of virus replication at the inoculated mucous membrane. J. Gen. Virol. 1993. 74: 379-385.
38. Costello, R. T., Therapeutic use of granulocyte-macrophage colony stimulating factor (GM-CSF). Acta Oncol. 1993. 32: 403-408.
39. Boraschi, D., Seldateschi, D. and Taliabue, A., Macrophage activation by interferon: dissociation between tumoricidal capacity and suppressive activity. Eur. J. Immunol. 1982. 12: 320-326.
40. Minato, N., Reid, L., Cantor, H., Lengyel, P. and Bloom, B. R., Mode of regulation of natural killer cell activity by interferon. J. Exp. Med. 1980. 152: 124-137.
41. Habu, S., Akamatsu, K. I., Tamaoki, N. and Okumura, K., In vivo significance of NK cell on resistance against virus (HSV-1) infections in mice. J. Immunol. 1984. 133: 2743-2747.
42. Pachuk, C. J., Arnold, R., Herold, K., Ciccarelli, R. B. and Higgins, T. J., Humoral and cellular immune responses to herpes simplex virus-2 glycoprotein D generated by facilitated DNA immunization of mice. Curr. Top. Microbiol. Immunol. 1998. 226: 79-89.