Enhanced protection against influenza virus of mice immunized as newborns with a mixture of plasmids expressing hemagglutinin and nucleoprotein

Vaccine

Volumn 16, Issue 17, 1998, Pages 1675-1682

  Bot, Adrian ^a   Bot, Simona ^a   Bona, Constantin ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

DNA vaccine; Influenza vaccines; Neonatal immunization

Indexed keywords

CD4 ANTIGEN; CYTOKINE; DNA VACCINE; GAMMA INTERFERON; INTERLEUKIN 4; VIRUS ANTIBODY; VIRUS HEMAGGLUTININ; VIRUS NUCLEOPROTEIN;

ADOLESCENT; AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEMAGGLUTINATION INHIBITION TEST; IMMUNIZATION; INFLUENZA VIRUS; MOUSE; NEWBORN; NONHUMAN; PLASMID; PRIORITY JOURNAL; T LYMPHOCYTE; ULTRAVIOLET IRRADIATION; VIRUS INACTIVATION;

ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; IMMUNIZATION; INFLUENZA VACCINES; MICE; MICE, INBRED BALB C; NUCLEOCAPSID PROTEINS; NUCLEOPROTEINS; PLASMIDS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER; VACCINES, DNA; VIRAL CORE PROTEINS;

EID: 0032192577     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00054-1     Document Type: Article

References (20)

1. 1 Siegrist, C.-A. Potential advantages and risks of nucleic acid vaccines for infant immunization. Vaccine 1997, 15, 798-800.
2. 2 Billingham, R., Brent, L. and Medawar, P. Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance. Proc. Roy. Soc. London 1956, 239, 44-45.
3. 3 Silverstein, A,M. and Segal, S. The ontogeny of antigen-specific T cells. J. Exp. Med. 1975, 142, 802-804.
4. 4 Coutinho, G.C., Delassus, S. and Kourilsky, P. et al. Developmental shift in the patterns of interleukin production in early post-natal life. Eur. J. Immunol. 1994, 24, 1858-1862.
5. 5 Bot, A., Bot, S., Garcia-Sastre, A. and Bona, C. DNA immunization of newborn mice with a plasmid expressing nucleoprotein of influenza virus. Viral Immunol. 1996, 9, 207-210.
6. 6 Bot, A., Antohi, S., Bot, S., Garcia-Sastre, A. and Bona, C. Induction of cellular and humoral immunity against influenza virus by immunization of newborn mice with a plasmid bearing a hemagglutinin gene. Int. Immunol. 1997, 9, 1641-1650.
7. 7 Wang, Y., Xiang, Z., Pasquini, S. and Ertl, H.C.J. Immune response to neonatal genetic immunization. Virology 1997, 228, 278-284.
8. 8 Prince, A.M., Whalen, R. and Brotman, B. Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus. Vaccine 1997, 15, 916-919.
9. 9 Bagarazzi, M.L., Boyer, J.D., Javadian, M.A. and Weiner, D.B. et al. Safety and immunogenicity of intramuscular and intravaginal delivery of HIV-1 DNA constructs to infant chimpanzees. J. Med. Primatol. 1997, 26, 27-33.
10. 10 Martinez, X., Brandt, C., Saddallah, F. and Siegrist, C.-A. et al. DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life. Proc. Natl. Acad. Sci. USA 1997, 94, 8726-8731.
11. 11 Bot, A., Bot. S., Garcia-Sastre, A. and Bona, C. Protective cellular immunity against Influenza virus induced by plasmid inoculation of newborn mice. Dev. Immunol., in press.
12. 12 Ulmer, J.B., Donnelly, J.J. and Liu, M.A. et al. Heterologous protection against Influenza by injection of DNA encoding a viral protein. Science 1993, 259, 1745-1749.
13. 13 Reed, L.J. and Muench, H. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 1938, 27, 493-497.
14. 14 Corr, M., Lee, D.J., Carson, D.A. and Tighe, H. Gene vaccination with naked plasmid DNA: mechanism of CTL priming. J. Exp. Med. 1996, 184, 1555-1559.
15. 15 Fu, T.M., Ulmer, J.B., Caulfield, M.J. and Liu, M.A. et al. Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol. Med. 1997, 3, 362-371.
16. 16 Sato, Y., Roman, M., Tighe, H. and Raz, E. et al. Immunostimulatory DNA sequences necessary for effective intradermal DNA immunization. Science 1996, 273, 352-354.
17. 17 Deck, R.R., DeWitt, C.M., Donnelly, J.J., Liu, M.A. and Ulmer, J.B. Characterization of humoral immune response induced by an influenza hemagglutinin DNA vaccine. Vaccine 1997, 15, 71-78.
18. 18 Mor, G., Yamshchikov, G., Sedegah, M. and Klinman, D.M. et al. Induction of neonatal tolerance by plasmid DNA vaccination of mice. J. Clin. Invest. 1996, 98, 2700-2705.
19. 19 Li, S., Schulman, J., Itamura, S. and Palese, P. Glycosylation of neuraminidase determines the neurovirulence of influenza A/WSN/33 virus. J. Virol. 1993, 67, 6667-6673.
20. 20 Donnelly, J.J., Friedman, A., Martinez, D. and Liu, M.A. et al. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus. Nature Med. 1995, 1, 583-587.