메뉴 건너뛰기




Volumn 17, Issue 9-10, 1999, Pages 1136-1144

Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating factor gene in intramuscular DNA immunization

Author keywords

Bicistronic plasmid; DNA immunization; Hepatitis C virus; Nonstructural protein

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; STRUCTURAL PROTEIN; VIRUS PROTEIN;

EID: 0344097496     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00333-8     Document Type: Article
Times cited : (44)

References (64)
  • 1
    • 0024377134 scopus 로고
    • Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis
    • Alter H.J., Purcell R., Shih J., Melpolder J., Houghton M., Choo Q.L., Kuo G. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med. 321:1989;1494-1500.
    • (1989) N Engl J Med , vol.321 , pp. 1494-1500
    • Alter, H.J.1    Purcell, R.2    Shih, J.3    Melpolder, J.4    Houghton, M.5    Choo, Q.L.6    Kuo, G.7
  • 2
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo Q.L., Kuo G., Weiner A.J., Overby L.R., Bradley D.W., Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 244:1989;359-362.
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 6
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • Grakoui A., Wychowski C., Lin C., Feinstone S.M., Rice C.M. Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol. 67:1993;1385-1395.
    • (1993) J Virol , vol.67 , pp. 1385-1395
    • Grakoui, A.1    Wychowski, C.2    Lin, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 9
    • 0027507602 scopus 로고
    • Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C
    • Erickson A.L., Houghton M., Choo Q.L., Weiner A.J., Ralston R., Muchmore E., Walker C.M. Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C. J Immunol. 151:1993;4189-4199.
    • (1993) J Immunol , vol.151 , pp. 4189-4199
    • Erickson, A.L.1    Houghton, M.2    Choo, Q.L.3    Weiner, A.J.4    Ralston, R.5    Muchmore, E.6    Walker, C.M.7
  • 10
    • 0029844635 scopus 로고    scopus 로고
    • Immunogenicity and antigenicity of the ATPase/helicase domain of the hepatitis C virus nonstructural 3 protein
    • Sallberg M., Zhang Z.X., Chen M., Jin L., Birkett A., Peterson D.L., Milich D.R. Immunogenicity and antigenicity of the ATPase/helicase domain of the hepatitis C virus nonstructural 3 protein. J Gen Virol. 77:1996;2721-2728.
    • (1996) J Gen Virol , vol.77 , pp. 2721-2728
    • Sallberg, M.1    Zhang, Z.X.2    Chen, M.3    Jin, L.4    Birkett, A.5    Peterson, D.L.6    Milich, D.R.7
  • 11
    • 0030685837 scopus 로고    scopus 로고
    • Immune responses to the hepatitis C virus NS4A protein are profoundly influenced by the combination of the viral genotype and the host major histocompatibility complex
    • Zhang Z.X., Chen M., Hultgren C., Birkett A., Milich D.R., Sallberg M. Immune responses to the hepatitis C virus NS4A protein are profoundly influenced by the combination of the viral genotype and the host major histocompatibility complex. J Gen Virol. 78:1997;2735-2746.
    • (1997) J Gen Virol , vol.78 , pp. 2735-2746
    • Zhang, Z.X.1    Chen, M.2    Hultgren, C.3    Birkett, A.4    Milich, D.R.5    Sallberg, M.6
  • 12
    • 0026094311 scopus 로고
    • Identification of an immunodominant B-cell epitope on the hepatitis C virus nonstructural region defined by human monoclonal antibodies
    • Cerino A., Mondelli M.U. Identification of an immunodominant B-cell epitope on the hepatitis C virus nonstructural region defined by human monoclonal antibodies. J Immunol. 147:1991;2692-2696.
    • (1991) J Immunol , vol.147 , pp. 2692-2696
    • Cerino, A.1    Mondelli, M.U.2
  • 16
    • 0028872981 scopus 로고
    • Linear B-cell epitopes of the NS3-NS4-NS5 proteins of the hepatitis C virus as modeled with synthetic peptides
    • Khudyakov E., Khudyakova N.S., Jue D.L., Lambert S.B., Fang S., Fields H.A. Linear B-cell epitopes of the NS3-NS4-NS5 proteins of the hepatitis C virus as modeled with synthetic peptides. Virology. 206:1995;666-672.
    • (1995) Virology , vol.206 , pp. 666-672
    • Khudyakov, E.1    Khudyakova, N.S.2    Jue, D.L.3    Lambert, S.B.4    Fang, S.5    Fields, H.A.6
  • 17
    • 0028225961 scopus 로고
    • Significance of the immune response to a major, conformational B-cell epitope on the hepatitis C virus NS3 region defined by a human monoclonal antibody
    • Mondelli M.U., Cerino A., Boender P., Oudshoorn P., Middeldorp J., Fipaldini C., La Monica N., Habets W. Significance of the immune response to a major, conformational B-cell epitope on the hepatitis C virus NS3 region defined by a human monoclonal antibody. J Virol. 68:1994;4829-4836.
    • (1994) J Virol , vol.68 , pp. 4829-4836
    • Mondelli, M.U.1    Cerino, A.2    Boender, P.3    Oudshoorn, P.4    Middeldorp, J.5    Fipaldini, C.6    La Monica, N.7    Habets, W.8
  • 18
    • 0026633946 scopus 로고
    • Induction of cytotoxic T-cells to a cross-reactive epitope in the hepatitis C virus nonstructural RNA polymerase-like protein
    • Shirai M., Akatsuka T., Pendleton C.D., Houghten R., Wychowski C., Mihalik K., Feinstone S.M., Berzofsky J.A. Induction of cytotoxic T-cells to a cross-reactive epitope in the hepatitis C virus nonstructural RNA polymerase-like protein. J Virol. 66:1992;4098-4106.
    • (1992) J Virol , vol.66 , pp. 4098-4106
    • Shirai, M.1    Akatsuka, T.2    Pendleton, C.D.3    Houghten, R.4    Wychowski, C.5    Mihalik, K.6    Feinstone, S.M.7    Berzofsky, J.A.8
  • 19
    • 0029151623 scopus 로고
    • Possible mechanism involving T-lymphocyte response to nonstructural protein 3 in viral clearance in acute hepatitis C virus infection
    • Diepolder H.M., Zachoval R., Hoffmann R.M., Wierenga E.A., Santantonio T., Jung M.C., Eichenlaub D., Pape G.R. Possible mechanism involving T-lymphocyte response to nonstructural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet. 346:1995;1006-1007.
    • (1995) Lancet , vol.346 , pp. 1006-1007
    • Diepolder, H.M.1    Zachoval, R.2    Hoffmann, R.M.3    Wierenga, E.A.4    Santantonio, T.5    Jung, M.C.6    Eichenlaub, D.7    Pape, G.R.8
  • 20
    • 0029808747 scopus 로고    scopus 로고
    • The role of hepatitis C virus specific CD4+ T-lymphocytes in acute and chronic hepatitis C
    • Diepolder H.M., Zachoval R., Hoffmann R.M., Jung M.C., Gerlach T., Pape G.R. The role of hepatitis C virus specific CD4+ T-lymphocytes in acute and chronic hepatitis C. J Mol Med. 74:1996;583-588.
    • (1996) J Mol Med , vol.74 , pp. 583-588
    • Diepolder, H.M.1    Zachoval, R.2    Hoffmann, R.M.3    Jung, M.C.4    Gerlach, T.5    Pape, G.R.6
  • 22
    • 0028338654 scopus 로고
    • Direct injection of a recombinant retroviral vector induces human immunodeficiency virus-specific immune responses in mice and nonhuman primates
    • Irwin M.J., Laube L.S., Lee V., Austin M., Chada S., Anderson C.G., Townsend K., Jolly D.J., Warner J.F. Direct injection of a recombinant retroviral vector induces human immunodeficiency virus-specific immune responses in mice and nonhuman primates. J Virol. 68:1994;5036-5044.
    • (1994) J Virol , vol.68 , pp. 5036-5044
    • Irwin, M.J.1    Laube, L.S.2    Lee, V.3    Austin, M.4    Chada, S.5    Anderson, C.G.6    Townsend, K.7    Jolly, D.J.8    Warner, J.F.9
  • 24
    • 0027214439 scopus 로고
    • Bovine herpesvirus 1: Immune responses in mice and cattle injected with plasmid DNA
    • Cox G.J., Zamb T.J., Babiuk L.A. Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA. J Virol. 67:1993;5664-5667.
    • (1993) J Virol , vol.67 , pp. 5664-5667
    • Cox, G.J.1    Zamb, T.J.2    Babiuk, L.A.3
  • 26
    • 0027213712 scopus 로고
    • Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA
    • Robinson H.L., Hunt L.A., Webster R.G. Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA. Vaccine. 11:1993;957-960.
    • (1993) Vaccine , vol.11 , pp. 957-960
    • Robinson, H.L.1    Hunt, L.A.2    Webster, R.G.3
  • 28
    • 0031573081 scopus 로고    scopus 로고
    • Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations augmented with cytokine-expressing plasmids
    • Geissler M., Gesien A., Wands J.R. Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations augmented with cytokine-expressing plasmids. J Immunol. 159:1997;5107-5113.
    • (1997) J Immunol , vol.159 , pp. 5107-5113
    • Geissler, M.1    Gesien, A.2    Wands, J.R.3
  • 29
    • 0031569963 scopus 로고    scopus 로고
    • Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines
    • Iwasaki A., Stiernholm B.J., Chan A.K., Berinstein N.L., Barber B.H. Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. J Immunol. 158:1997;4591-4601.
    • (1997) J Immunol , vol.158 , pp. 4591-4601
    • Iwasaki, A.1    Stiernholm, B.J.2    Chan, A.K.3    Berinstein, N.L.4    Barber, B.H.5
  • 30
    • 0031252387 scopus 로고    scopus 로고
    • Intranasal immunization of a DNA vaccine with IL-12- And granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens
    • Okada E., Sasaki S., Ishii N., Aoki I., Yasuda T., Nishioka K., Fukushima J., Miyazaki J., Wahren B., Okuda K. Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens. J Immunol. 159:1997;3638-3647.
    • (1997) J Immunol , vol.159 , pp. 3638-3647
    • Okada, E.1    Sasaki, S.2    Ishii, N.3    Aoki, I.4    Yasuda, T.5    Nishioka, K.6    Fukushima, J.7    Miyazaki, J.8    Wahren, B.9    Okuda, K.10
  • 31
    • 0030735550 scopus 로고    scopus 로고
    • Protective immunity against heterologous challenge with encephalomyocarditis virus by VP1 DNA vaccination: Effect of coinjection with a granulocyte macrophage colony stimulating factor gene
    • Sin J.I., Sung J.H., Suh Y.S., Lee A.H., Chung J.H., Sung Y.C. Protective immunity against heterologous challenge with encephalomyocarditis virus by VP1 DNA vaccination: effect of coinjection with a granulocyte macrophage colony stimulating factor gene. Vaccine. 15:1997;1827-1833.
    • (1997) Vaccine , vol.15 , pp. 1827-1833
    • Sin, J.I.1    Sung, J.H.2    Suh, Y.S.3    Lee, A.H.4    Chung, J.H.5    Sung, Y.C.6
  • 32
    • 0031060327 scopus 로고    scopus 로고
    • Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2
    • Chow Y.H., Huang W.L., Chi W.K., Chu Y.D., Tao M.H. Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J Virol. 71:1997;169-178.
    • (1997) J Virol , vol.71 , pp. 169-178
    • Chow, Y.H.1    Huang, W.L.2    Chi, W.K.3    Chu, Y.D.4    Tao, M.H.5
  • 34
    • 0031592755 scopus 로고    scopus 로고
    • Comparison of various expression plasmids for the induction of immune response by DNA immunization
    • Lee A.H., Suh Y.S., Sung J.H., Yang S.H., Sung Y.C. Comparison of various expression plasmids for the induction of immune response by DNA immunization. Mol Cells. 7:1997;495-501.
    • (1997) Mol Cells , vol.7 , pp. 495-501
    • Lee, A.H.1    Suh, Y.S.2    Sung, J.H.3    Yang, S.H.4    Sung, Y.C.5
  • 36
  • 37
  • 38
    • 0003448569 scopus 로고
    • Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
    • Harlow E, Lane D. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1988. p. 561-91.
    • (1988) Antibodies: A Laboratory Manual , pp. 561-591
    • Harlow, E.1    Lane, D.2
  • 39
    • 0023766641 scopus 로고
    • Expression of a human placental alkaline phosphatase gene in transfected cells: Use as a reporter for studies of gene expression
    • Henthorn P., Zervos P., Raducha M., Harris H., Kadesch T. Expression of a human placental alkaline phosphatase gene in transfected cells: use as a reporter for studies of gene expression. Proc Natl Acad Sci USA. 85:1988;6342-6346.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6342-6346
    • Henthorn, P.1    Zervos, P.2    Raducha, M.3    Harris, H.4    Kadesch, T.5
  • 40
    • 0000639845 scopus 로고
    • Full genome cloning and nucleotide sequence analysis of hepatitis C virus from sera of chronic hepatitis patients in Korea
    • Cho Y.G., Yoon J.W., Jang K.L., Kim C.M., Sung Y.C. Full genome cloning and nucleotide sequence analysis of hepatitis C virus from sera of chronic hepatitis patients in Korea. Mol Cells. 3:1993;195-202.
    • (1993) Mol Cells , vol.3 , pp. 195-202
    • Cho, Y.G.1    Yoon, J.W.2    Jang, K.L.3    Kim, C.M.4    Sung, Y.C.5
  • 41
    • 0027423430 scopus 로고
    • Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle
    • Wells D.J. Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle. FEBS Lett. 332:1993;179-182.
    • (1993) FEBS Lett , vol.332 , pp. 179-182
    • Wells, D.J.1
  • 44
    • 0028089739 scopus 로고
    • Hepatitis C virus NS3 serine proteinase: Trans-cleavage requirements and processing kinetics
    • Lin C., Pragai B.M., Grakoui A., Xu J., Rice C.M. Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics. J Virol. 68:1994;8147-8157.
    • (1994) J Virol , vol.68 , pp. 8147-8157
    • Lin, C.1    Pragai, B.M.2    Grakoui, A.3    Xu, J.4    Rice, C.M.5
  • 46
    • 0017283397 scopus 로고
    • Cell-mediated immune response to mumps virus infection in man
    • Chiba Y., Dzierba J.L., Morag A., Ogra P.L. Cell-mediated immune response to mumps virus infection in man. J Immunol. 116:1976;12-15.
    • (1976) J Immunol , vol.116 , pp. 12-15
    • Chiba, Y.1    Dzierba, J.L.2    Morag, A.3    Ogra, P.L.4
  • 47
    • 0029550784 scopus 로고
    • Nucleic acid vaccination against virally induced tumors
    • Bright R.K., Shearer M.H., Kennedy R.C. Nucleic acid vaccination against virally induced tumors. Ann NY Acad Sci. 772:1995;241-251.
    • (1995) Ann NY Acad Sci , vol.772 , pp. 241-251
    • Bright, R.K.1    Shearer, M.H.2    Kennedy, R.C.3
  • 49
    • 0030693664 scopus 로고    scopus 로고
    • DNA immunization with a bovine rotavirus VP4 gene induces a Th1-like immune response in mice
    • Suradhat S., Yoo D., Babiuk L.A., Griebel P., Baca-Estrada M.E. DNA immunization with a bovine rotavirus VP4 gene induces a Th1-like immune response in mice. Viral Immunol. 10:1997;117-127.
    • (1997) Viral Immunol , vol.10 , pp. 117-127
    • Suradhat, S.1    Yoo, D.2    Babiuk, L.A.3    Griebel, P.4    Baca-Estrada, M.E.5
  • 50
    • 14844344681 scopus 로고
    • Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein
    • Zarozinski C.C., Fynan E.F., Selin L.K., Robinson H.L., Welsh R.M. Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein. J Immunol. 154:1995;4010-4017.
    • (1995) J Immunol , vol.154 , pp. 4010-4017
    • Zarozinski, C.C.1    Fynan, E.F.2    Selin, L.K.3    Robinson, H.L.4    Welsh, R.M.5
  • 51
    • 0029665097 scopus 로고    scopus 로고
    • Protection against a lethal tumor challenge with SV40-transformed cells by the direct injection of DNA-encoding SV40 large tumor antigen
    • Bright R.K., Beames B., Shearer M.H., Kennedy R.C. Protection against a lethal tumor challenge with SV40-transformed cells by the direct injection of DNA-encoding SV40 large tumor antigen. Cancer Res. 56:1996;1126-1130.
    • (1996) Cancer Res , vol.56 , pp. 1126-1130
    • Bright, R.K.1    Beames, B.2    Shearer, M.H.3    Kennedy, R.C.4
  • 52
    • 0031568095 scopus 로고    scopus 로고
    • In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
    • Kim J.J., Ayyavoo V., Bagarazzi M.L., Chattergoon M.A., Dang K., Wang B., Boyer J.D., Weiner D.B. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J Immunol. 158:1997;816-826.
    • (1997) J Immunol , vol.158 , pp. 816-826
    • Kim, J.J.1    Ayyavoo, V.2    Bagarazzi, M.L.3    Chattergoon, M.A.4    Dang, K.5    Wang, B.6    Boyer, J.D.7    Weiner, D.B.8
  • 53
    • 0031664801 scopus 로고    scopus 로고
    • Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte macrophage colony stimulating factor gene
    • Lee SW, Cho JH, Sung YC. Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte macrophage colony stimulating factor gene. J Virol 1998;72:8430-6.
    • (1998) J Virol , vol.72 , pp. 8430-8436
    • Lee, S.W.1    Cho, J.H.2    Sung, Y.C.3
  • 55
    • 0030811634 scopus 로고    scopus 로고
    • Nucleic acid vaccines: An overview
    • Robinson H.L. Nucleic acid vaccines: an overview. Vaccine. 15:1997;785-787.
    • (1997) Vaccine , vol.15 , pp. 785-787
    • Robinson, H.L.1
  • 56
    • 0031570044 scopus 로고    scopus 로고
    • Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations
    • Torres C.A., Iwasaki A., Barber B.H., Robinson H.L. Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations. J Immunol. 158:1997;4529-4532.
    • (1997) J Immunol , vol.158 , pp. 4529-4532
    • Torres, C.A.1    Iwasaki, A.2    Barber, B.H.3    Robinson, H.L.4
  • 57
    • 0030845852 scopus 로고    scopus 로고
    • Amplification of T-cell and antibody responses in DNA-based immunization with HIV-1 Nef by coinjection with a GM-CSF expression vector
    • Svanholm C., Lowenadler B., Wigzell H. Amplification of T-cell and antibody responses in DNA-based immunization with HIV-1 Nef by coinjection with a GM-CSF expression vector. Scand J Immunol. 46:1997;298-303.
    • (1997) Scand J Immunol , vol.46 , pp. 298-303
    • Svanholm, C.1    Lowenadler, B.2    Wigzell, H.3
  • 58
    • 0028244596 scopus 로고
    • Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus
    • Xiang Z.Q., Spitalnik S., Tran M., Wunner W.H., Cheng J., Ertl H.C. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology. 199:1994;132-140.
    • (1994) Virology , vol.199 , pp. 132-140
    • Xiang, Z.Q.1    Spitalnik, S.2    Tran, M.3    Wunner, W.H.4    Cheng, J.5    Ertl, H.C.6
  • 61
    • 0029811057 scopus 로고    scopus 로고
    • T- And B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia
    • Lechmann M., Ihlenfeldt H.G., Braunschweiger I., Giers G., Jung G., Matz B., Kaiser R., Sauerbruch T., Spengler U. T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia. Hepatology. 24:1996;790-795.
    • (1996) Hepatology , vol.24 , pp. 790-795
    • Lechmann, M.1    Ihlenfeldt, H.G.2    Braunschweiger, I.3    Giers, G.4    Jung, G.5    Matz, B.6    Kaiser, R.7    Sauerbruch, T.8    Spengler, U.9
  • 62
    • 10244225383 scopus 로고    scopus 로고
    • Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
    • Missale G., Bertoni R., Lamonaca V., Valli A., Massari M., Mori C., Rumi M.G., Houghton F., Fiaccadori F., Ferrari C. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J Clin Invest. 98:1996;706-714.
    • (1996) J Clin Invest , vol.98 , pp. 706-714
    • Missale, G.1    Bertoni, R.2    Lamonaca, V.3    Valli, A.4    Massari, M.5    Mori, C.6    Rumi, M.G.7    Houghton, F.8    Fiaccadori, F.9    Ferrari, C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.