Effects of DNA immunization formulated with bupivacaine in murine and guinea pig models of genital herpes simplex virus infection

Vaccine

Volumn 17, Issue 15-16, 1999, Pages 1964-1969

  Bernstein, David I ^a   Tepe, Eric R ^a   Mester, Joseph C ^a   Arnold, Renee L ^b   Stanberry, Lawrence R ^a   Higgins, Terry ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b Wyeth Lederle Vaccines   (United States)

Author keywords

DNA immunization; Genital herpes; HSV vaccine

Indexed keywords

BUPIVACAINE; HERPES SIMPLEX VACCINE;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; DRUG FORMULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENITAL HERPES; GUINEA PIG; HERPES SIMPLEX VIRUS 2; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, VIRAL; BUPIVACAINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GUINEA PIGS; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; LYMPHOCYTE ACTIVATION; MICE; NEUTRALIZATION TESTS; RECURRENCE; SKIN; TIME FACTORS; VACCINES, DNA; VAGINA; VIRAL ENVELOPE PROTEINS; VIRAL VACCINES; VIRUS REPLICATION; VIRUS SHEDDING;

EID: 0033538012     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00469-1     Document Type: Article

References (26)

1. Fleming D.T., McQuillan G.M., Johnson R.E., Nahmias A.J., Aral S.O., Lee F.K., St. Louis M.E. Herpes simplex virus type 2 in the United States, 1976 to 1994. N. Engl. J. Med. 337:1997;1105-1111.
2. Stanberry LR. Subunit viral vaccines: prophylactic and therapeutic use. In: Aurelian L, editor. Herpesviruses, the immune system and AIDS. Boston, MA: Kluwer Academic Publishers, 1991. p. 309-41.
3. Bernstein DI. Herpes simplex virus vaccines. In: Aly R, Beutner KR, Maibach HI, editors. Cutaneous infection and therapy. New York, NY: Marcel Dekker, 1997. p. 317-32.
4. Corey L. Developing a genital herpes simplex virus vaccine. Abstracts of the 37th ICAAC. 1997, p. 392 (Abstract).
5. Bishopp F. Chiron's stock dives on news that herpes vaccine failure. Bioworld Today. 7(1):1996;4.
6. Wolff J.A., Malone R.W., Williams P.et al. Direct gene transfer into mouse muscle in vivo. Science. 247:1990;1465-1468.
7. Ulmer J.B., Donnelly J.J., Parker S.E.et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science. 259:1993;1745-1749.
8. Robinson H.L., Hunt L.A., Webster R.G. Protection against a lethal influenza virus challenge by immunization with a hemagglutinin-expressing plasmid DNA. Vaccine. 11:1993;957-960.
9. Donnelly J.J., Ulmer J.B., Shiver J.W., Liu M.A. DNA vaccines. Ann. Rev. Immunol. 15:1997;617-648.
10. Robinson H.L., Torres C.A. DNA vaccines. Semin. Immunol. 9:1997;271-283.
11. Bourne N., Stanberry L.R., Bernstein D.I., Lew D. DNA immunization against experimental genital herpes simplex virus infection. J. Infect. Dis. 173:1996;800-807.
12. McClements W.L., Armstrong M.E., Keys R.D., Liu M.A. Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces immunity in animal models of herpes simplex virus-2 disease. Proc. Natl. Acad. Sci. USA. 93:1996;11414-11420.
13. Manickan E., Rouse R.J., Yu Z., Wire W.S., Rouse B.T. Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T-lymphocytes. J. Immunol. 155:1995;259-265.
14. Danko I., Fritz J.D., Jiao S., Hogan K., Latendresse J.S., Wolff J.A. Pharmacological enhancement of in vivo foreign gene expression in muscle. Gene Ther. 1:1993;1-8.
15. Vitadello M., Schiaffino M.V., Picard A., Scarpa M., Shiaffino S. Gene transfer in regenerating muscle. Human Gene Ther. 5:1994;11-18.
16. Wells D.J. Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle. FEBS Lett. 332:1993;179-182.
17. Cantini M., Massimino M.L., Catani C., Rizzuto R., Brini M., Carraro U. Gene transfer into satellite cell from regenerating muscle: bupivacaine allows beta-Gal transfection and expression in vitro and in vivo. In Vitro Cell Dev. Biol. Anim. 30A(2):1994;131-133.
18. Milligan G.N., Bernstein D.I. Generation of humoral responses against herpes simplex virus type 2 (HSV-2) in the murine female genital tract. Virology. 206:1995;234-241.
19. Stanberry L.R. Evaluation of herpes simplex virus vaccines in animals: the guinea pig vaginal model. Rev. Infect. Dis. 13:1991;S920-S923.
20. Stanberry L.R., Bernstein D.I., Burke R.L., Pachl C., Myers M.G. Recombinant herpes simplex virus glycoprotein vaccine protects against initial and recurrent genital herpes. J. Infect. Dis. 155:1987;914-920.
21. Bernstein D.I., Miller R.L., Harrison C.J. Adjuvant effects of imiquimod on a herpes simplex virus type 2 glycoprotein vaccine in guinea pigs. J. Infect. Dis. 167:1993;731-735.
22. Packuk C.J., Arnold R., Herold K., Ciccarelli R.B., Higgins T.J. Humoral and cellular immune responses to herpes simplex virus-2 glycoprotein D generated by facilitated DNA immunization of mice. Curr. Top. Microbiol. Immunol. 226:1998;79-89.
23. Bourne N., Milligan G.N., Schleiss M.R., Bernstein D.I., Stanberry L.R. DNA immunization confers protective immunity on mice challenged intravaginally with herpes simplex virus type 2. Vaccine. 377:1996;1-6.
24. Milligan G.N., Bernstein D.I., Bourne N. T-lymphocytes are required for protection of the vaginal mucosa and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2. J. Immunol. 160:1998;6093-6100.
25. Posavad C.M., Koelle D.M., Shaughnessy M.F., Corey L. Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T-lymphocyte responses. Proc. Natl. Acad. Sci. USA. 94:1997;10289-10294.
26. Langenberg A.G., Burke R.L., Adair S.F., Sekulovich R., Tigges M., Dekker C.L., Corey L. A recombinant glycoprotein vaccine for herpes simplex virus type 2: safety and immunogenicity. Ann. Int. Med. 122:1995;889-898.