The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: A new facet to Knudson's 'two-hit' hypothesis

Nature Medicine

Volumn 5, Issue 9, 1999, Pages 1071-1075

  Lamlum, Hanan ^a   Ilyas, Mohammad ^b   Rowan, Andrew ^a   Clark, Susan ^c   Johnson, Victoria ^c   Bell, Jennie ^c   Frayling, Ian ^c   Efstathiou, Jason ^b   Pack, Kevin ^c   Payne, Stewart ^c   Roylance, Rebecca ^a   Gorman, Patricia ^a   Sheer, Denise ^a   Neale, Kay ^c   Phillips, Robin ^c   Talbot, Ian ^c   Bodmer, Walter ^b   Tomlinson, Ian ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c EALING HOSPITAL NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYP; ARTICLE; CODON; DESMOID TUMOR; DISEASE SEVERITY; FAMILIAL POLYPOSIS; FRAMESHIFT MUTATION; GENE MUTATION; HUMAN; HUMAN TISSUE; MISSENSE MUTATION; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

ADENOMA; ADENOMATOUS POLYPOSIS COLI; ALLELES; BASE SEQUENCE; CODON; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; EXONS; FAMILY HEALTH; FIBROMATOSIS, AGGRESSIVE; FRAMESHIFT MUTATION; GENE DELETION; GENE FREQUENCY; GENES, APC; GERM-LINE MUTATION; HUMANS; MODELS, GENETIC; MUTATION;

EID: 0032823133     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/12511     Document Type: Article

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