Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain

Mechanisms of Development

Volumn 80, Issue 2, 1999, Pages 147-151

  Hedgepeth, Chester M ^a   Deardorff, Matthew A ^a   Klein, Peter S ^a  

^a Div Hematol Oncol Dept Med H   (United States)

Author keywords

Axin; Development; Forebrain midbrain boundary; Glycogen synthase kinase 3 beta; Midbrain; Wnts; Xenopus; Yeast two hybrid

Indexed keywords

AXIN; BETA CATENIN; CASEIN KINASE; CASEIN KINASE III; GENE PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; COLON POLYPOSIS; EMBRYO AXIS; ENZYME SUBUNIT; FOREBRAIN; MESENCEPHALON; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; IN SITU HYBRIDIZATION, FLUORESCENCE; MESENCEPHALON; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PROTEINS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS;

VERTEBRATA;

EID: 0032981560     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(98)00203-2     Document Type: Article

References (18)

1. Behrens J., Jerchow B.-A., Wurtele M., Grimm J., Asbrand C., Wirtz R., Kuhl M., Wedlich D., Birchmeier W. Functional interaction of an axin homolog, conductin, with β-catenin, APC and GSK-3β Science. 280:1998;596-599.
2. Fields S., Song O. A novel genetic system to detect protein-protein interactions. Nature. 340:1989;245-247.
3. Harland, R.M., 1991. In situ hybridization: an improved wholemount method for Xenopus embryos. In Kay, B.K., Peng, H.B. (Eds.), Methods in Cell Biology, Vol. 36. Academic Press, San Diego, CA.
4. Harper J.W., Adami G.R., Wei N., Keyomarski K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kineses. Cell. 75:1993;805-816.
5. Hart M.J., Santos R., Albert I., Rubinfeld B., Polakis P. Downregulation of β-catenin by human axin and its association with the APC tumor supressor, β-catenin, and GSK3β Curr. Biol. 8:1998;573-581.
6. Hemmati-Brivanlou A., Harland R.M. Expression of an engrailed-related protein is induced in the anterior neural ectoderm of early Xenopus embryos. Development. 106:1989;611-617.
7. Ikeda S., Kishida S., Yamamoto H., Murai H., Koyama S., Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin. EMBO J. 17:1998;1371-1384.
8. Islam N., Moss T. Enzymatic removal of vitelline membrane and other protocol modifications for whole mount in situ hybridization of Xenopus embryos. Trends Genet. 12:1996;459.
9. Itoh K., Krupnik V.E., Sokol S.Y. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin. Curr. Biol. 8:1998;591-594.
10. Jowett T., Yan Y.L. Double fluorescent in situ hybridization to zebrafish embryos. Trends Genet. 12:1996;337-339.
11. Landesman Y., Sokol S.Y. Xwnt-2b is a novel axis-inducing Xenopus Wnt, which is expressed in embryonic brain. Mech. Dev. 63:1997;199-209.
12. Moos M. Jr., Wang S., Krinks M. Anti-dorsalizing morphogenetic protein is a novel TGF-beta homolog expressed in the Spemann organizer. Development. 121:1995;4293-4301.
13. Perry W.L., Vasicek T.J., Lee J.J., Rossi J.M., Zeng L., Zhang T., Tilghman S.M., Costantini F. Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus. Genetics. 141:1995;321-332.
14. Pierce S.B., Kimelman D. Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3. Development. 121:1995;755-765.
15. Sakanaka C., Weiss J.B., Williams L.T. Bridging if β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription. Proc. Natl. Acad. Sci. USA. 95:1998;3020-3023.
16. Wilson P.A., Melton D.A. Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. biol. 4:1994;676-686.
17. Yamamoto H., Kishida S., Uochi T., Ikeda S., Koyama S., Asashima M., Kikuchi A. Axil, a member of the axin family, interacts with both glycogen synthase kinase 3β and β-catenin and inhibits axis formation in Xenopus embryos. Mol. Cell. Biol. 18:1998;2867-2875.
18. Zeng L., Fagotto F., Zhang T., Hsu W., Vasicek T.J., Perry W.L., Lee J.J., Tilghman S.M., Gumbiner B.M., Costantini F. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell. 90:1997;181-192.