TCR-independent T cell development mediated by gain-of-oncogene function or loss-of-tumor-suppressor gene function

Seminars in Immunology

Volumn 12, Issue 5, 2000, Pages 487-502

  Jacobs, Heinz ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

Complementation tagging; Lymphomagenesis; Oncogenes; Proviral insertion mutagenesis; Provirus tagging; Rag recombination activating gene; T cell development; Tumor suppressor

Indexed keywords

CD3 ANTIGEN; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 7 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PROTEIN P53; PROTEIN TYROSINE KINASE; RAS PROTEIN; RHO FACTOR; STEM CELL FACTOR RECEPTOR; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR;

CARCINOGENESIS; GENE INACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPOIESIS; MUTAGENESIS; NONHUMAN; ONCOGENE MYC; PROTO ONCOGENE; PROVIRUS; REVIEW; T LYMPHOCYTE; TUMOR SUPPRESSOR GENE;

EID: 0033736036     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.2000.0262     Document Type: Article

References (170)

1. Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes
2. Molecular and cellular events in early thymocyte development
3. Early T lymphocyte progenitors
4. In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development
5. A new acute transforming feline retro-virus and relationship of its oncogene v-kit with the protein kinase gene family
6. Jaks and STATs: Biological implications
7. The Jak-Stat pathway in normal and perturbed hematopoiesis
8. Cell-fate decisions in early T cell development: Regulation by cytokine receptors and the pre-TCR
9. Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation
10. CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo
11. Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain
12. Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required
13. Function of the CD3 subunits of the pre-TCR and TCR complexes during T cell development
14. Domains of the TCR beta-chain required for early thymocyte development
15. Pre-TCR/CD3 and TCR/CD3 complexes: Decamers with differential signaling properties?
16. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains
17. Signals involved in gamma/delta T cell versus alpha/beta T cell lineage commitment
18. Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: A critical role for the beta chain in development
19. Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment
20. In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes
21. T cell depletion in transgenic mice carrying a mutant gene for TCR-beta
22. The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci
23. Allelic exclusion in pTalpha-deficient mice: No evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogenous Vbeta→ (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene
24. Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus
25. Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein
26. Development and selection of T cells: Facts and puzzles
27. CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage
28. Signals involved in CD4/CD8 lineage commitment: Current concepts and potential mechanisms
29. Regulation of lineage commitment distinct from positive selection
30. Antigen receptor tail clue
31. Protein tyrosine kinases in thymocyte development
32. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide
33. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor
34. T cell antigen-receptor signal transduction
35. The role of SLP-76 and LAT in lymphocyte development
36. Impaired visability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
37. Essential role of LAT in T cell development
38. A lymphocyte-specific protein-tyrosine kinase gene is rear-ranged and overexpressed in the murine T cell lymphoma LSTRA
39. Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells
40. Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion
41. Role of phosphatase in lymphocyte activation
42. CSK: A protein-tyrosine kinase involved in regulation of src family kinases
43. Negative regulation of T-cell receptor signaling by tyrosine protein kinase p50csk
44. Thymic tumorigenesis induced by overexpression of p561ck
45. Frequency activation of the lck gene by promoter insertion and aberrant splicing in murine leukemia virus-induced rat lymphomas
46. Profound block in thymocyte development in mice lacking p56lck
47. A dominant-negative transgene defines a role for p56lck in thymopoiesis
48. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn
49. Fyn can partially substitute for Lck in T lymphocyte development
50. Alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases
51. An activated lck transgene promotes thymocyte development in RAG-l-mutant mice
52. The role of membrane-associated adaptors in T cell receptor signaling
53. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
54. Ras protein signaling
55. Signals involved in thymocyte positive and negative selection
56. Selective requirement for MAP kinase activation in thymocyte differentiation
57. Involvement of p21ras distinguishes positive and negative selection in thymocytes
58. Activated Ras signals differentiation and expansion of CD4+8+ thymocytes
59. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
60. Proliferation kinetics associated with T cell receptor-beta chain selection of fetal murine thymocytes
61. Targets of p56(lck) activity in immature thymoblasts: Stimulation of the Ras/Raf/MAPK pathway
62. Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion
63. + distinguished in Egr-1 transgenic mice with a RAG-2-/- background
64. Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells
65. Vav links antigen-receptor signaling to the actin cytoskeleton
66. + thymocytes
67. Defective signaling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
68. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
69. Rho GTPases and signaling networks
70. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through Gl. Science
71. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
72. GTPases in antigen receptor signalling
73. The GTPase Rho has a critical regulatory role in thymus development
74. Inhibition of Rho at different stages of thymocyte development gives different perspectives on Rho function
75. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins
76. Phosphorylation of c-jun mediated by MAP kinases
77. JNKI: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
78. Activation of ternary complex factor Elk-1 by stress-activated protein kinases
79. Transcription factor ATF2 regulation by the JNK signal transduction pathway
80. Pharmacological regulation of network kinetics by protein kinase C localization
81. The I kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling
82. Selective modulation of protein kinase C-theta during T-cell activation
83. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
84. Transformation by reticuloendotheliosis virus: Development of a focus assay and isolation of a nontransforming virus
85. Isolation of the avian reticuloendothelial virus (strain T)
86. The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice
87. IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice
88. Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoiedc cells
89. Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase
90. Constitutive activation of Src family kinases in mouse embryos that lack Csk
91. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice
92. Csk controls antigen receptor-mediated development and selection of T-lineage cells
93. The Cbl family of signal transduction molecules
94. The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein
95. A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein
96. Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene
97. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
98. The Cbl protooncoprotein: A negative regulator of immune receptor signal transduction
99. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet- growth factor alpha
100. The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells
101. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
102. Altered thymic positive selection and intracellular signals in Cbl-deficient mice
103. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
104. Cbl-b regulates the CD28 dependence of T-cell activation
105. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
106. Lessons from the p53-mutant mouse
107. Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double-mutant mice
108. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
109. V(D)J recombination is not required for the development of lymphoma in p53-deficient mice
110. + stage of thymocyte differentiation in the absence of T cell receptor rearrangement
111. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
112. A severe combined immunodeficiency mutation in the mouse
113. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes
114. Mutations in the p53 and SCID genes cooperate in tumorigenesis
115. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells
116. Retroviral insertional mutagenesis as a strategy to identify cancer genes
117. Tumorigenesis by slowtransforming retroviruses an update
118. Identification and characterization of collaborating oncogenes in compound mutant mice
119. Complementation tagging of cooperating oncogenes in knockout mice
120. PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice
121. Proviral activation of the putative oncogene Pim-1 in MuLV-induced T-cell lymphomas
122. The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases
123. Proviral tagging in E mu-myc-transgenic mice lacking the Pim-1 protooncogene leads to compensatory activation of Pim-2
124. KID-1, a protein kinase induced by depolarization in brain
125. Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc
126. Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally
127. Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mass cells
128. Pim-1 levels determine the size of early B lymphoid compartments in bone marrow
129. Analysis of Pim-1 function in mutant mice
130. Pim-1 kinase and p100 cooperate to enhance c-Myb activity
131. Dominant interfering alleles define a role for c-Myb in T-cell development
132. T-cell lymphomas in v-Myb-transgenic mice
133. Reassessing the role of C-MYB in tumorigenesis
134. Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection
135. Predisposition to lymphomagenesis in pim-1-transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors
136. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in antiapoptosis
137. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
138. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging
139. Evi-5, a common site of retroviral integration in AKXD T-cell lymphomas, maps near Gfi-1 on mouse chromosome 5
140. Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins
141. Characterpzation of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1-transgenic mice
142. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein
143. The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death
144. The Gfi-1 protooncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal
145. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor
146. The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation
147. Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis
148. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mumyc-transgenic mice
149. Sequence similarity between the mammalian bmi1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2
150. Transformation of axial skeleton due to overexpression of bmi-1 in-transgenic mice
151. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
152. The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression
153. MPc-2, a new murine homolog of the drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex
154. Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex
155. The oncogene and polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
156. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc- induced apoptosis via INK4a/ARF
157. Cellular memory of transcriptional states by polycomb-group proteins
158. Bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis
159. Perturbation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1-transgenic mice require the Bmi1 RING finger
160. The role of mel-18, a mammalian polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors
161. Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi-1-transgenic mice requires the Bmi-1 RING finger
162. Function of the c-Myc oncogenic transcription factor
163. The molecular role of Myc in growth and transformation: Recent discoveries lead to new insights
164. New Myc-interacting proteins: A second Myc network emerges
165. The many roles of c-Myc in apoptosis
166. Target genes and cellular regulators of the Myc transcription complex
167. The role of c-myc in cellular growth control
168. The programmed cell death of an immature thymocyte cell line transgenic for an alpha beta TCR and the c-myc protooncogene