Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

Journal of Molecular Biology

Volumn 281, Issue 3, 1998, Pages 523-537

  Fütterer, Klaus ^a   Wong, Jane ^b   Grucza, Richard A ^a   Chan, Andrew C ^b,c   Waksman, Gabriel ^a  

^a Camp Box 8231 660 S Euclid A ^*  (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

ITAM; SH2 domains; Syk kinase; X ray crystal structure

Indexed keywords

MEMBRANE RECEPTOR; PROTEIN TYROSINE KINASE;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0032555744     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.1964     Document Type: Article

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